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neurogenetics

, Volume 10, Issue 4, pp 355–358 | Cite as

Ashkenazi Parkinson’s disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries

  • Anat Bar-Shira
  • Carolyn M. Hutter
  • Nir Giladi
  • Cyrus P. Zabetian
  • Avi Orr-Urtreger
Short Communication

Abstract

The LRRK2 G2019S mutation is a major genetic determinant of Parkinson’s disease (PD) across the world that occurs at an elevated frequency in Ashkenazi Jews. We determined the LRRK2 haplotypes in 77 G2019S carriers, mostly Ashkenazi Jews, and in 50 noncarrier Ashkenazi PD patients, using 16 genetic markers. A single haplotype was detected in all mutation carriers, indicating that these individuals share a common founder. Using a maximum-likelihood method, we estimate that Ashkenazi Jews with G2019S share a common ancestor who lived ∼1,830 (95% CI 1,560–2,160) years ago, around the second century, after the second Jewish Diaspora.

Keywords

Parkinson’s disease Haplotype Ashkenazi Jews LRRK2 G2019S mutation Founder mutation 

Notes

Acknowledgments

The assistance of Dr. Helena Yagev-More is gratefully acknowledged. This work was supported by grants from National Parkinson Foundation, Miami, USA, Tel Aviv Sourasky Medical Center Grant of Excellence, and Wolfson and Kahn Foundations.

Declaration

The experiments were complied with the current laws of Israel, the country in which they were performed.

Supplementary material

10048_2009_186_MOESM1_ESM.xls (44 kb)
Supplementary Table. LRRK2 G2019S Haplotypes (XLS 43 KB)

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Anat Bar-Shira
    • 1
  • Carolyn M. Hutter
    • 4
  • Nir Giladi
    • 2
    • 3
  • Cyrus P. Zabetian
    • 5
    • 6
  • Avi Orr-Urtreger
    • 1
    • 3
  1. 1.Genetic InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael
  2. 2.Movement Disorders Unit Parkinson Center, Department of NeurologyTel-Aviv Sourasky Medical CenterTel AvivIsrael
  3. 3.The Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  4. 4.Department of Epidemiology, School of Public Health and Community MedicineUniversity of WashingtonSeattleUSA
  5. 5.Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care SystemUniversity of Washington School of MedicineSeattleUSA
  6. 6.Department of NeurologyUniversity of Washington School of MedicineSeattleUSA

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