Association of progesterone receptor with migraine-associated vertigo
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While migraine has been demonstrated to be familial and have genetic contributions, genome-wide linkage analyses and candidate gene studies have highlighted that migraine is genetically complex. Despite substantial efforts, no consistent replication of linkage or association has been reported for common migraine syndromes. Among the candidate genes tested for association with migraine by several groups were female sex hormone genes based on the observation of a much higher incidence of migraine in females. Migraine-associated vertigo (MAV) is a migraine syndrome also much more common in females than males. Because MAV is less common in the general population than migraine or migraine with aura, it may be a better migraine syndrome to detect susceptibility alleles. In this study, we tested the association of two female hormonal genes, progesterone receptor (PGR) and estrogen receptor (ESR1), which were previously reported to be associated with migraine in women. We typed 150 MAV subjects and 145 genomic matched control subjects. One SNP (rs1042838) within PGR, which is in high linkage disequilibrium with the functional PROGINS variant, was significantly associated with MAV (p = 0.0007). Two SNPs (rs2228480 and rs1801132) within ESR1 demonstrated no significant association. No synergistic effect between ESR1 variants and PGR variants was identified.
KeywordsMigraine-associated vertigo Progesterone receptor PROGINS Association
We are grateful to the patients and their families for participating in this research study. We thank S. L. Stoddart for the sample preparation. Genotyping was performed with the assistance of the UCLA Southern California Genotyping Consortium (SCGC). We thank the members of the Nelson Lab for the guidance and input. This study was supported by a program project grant NIH/NIDCD P50 DC 05224.
Conflict of interest statement
The authors declare no competing interests.
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