Neurogenetics

, Volume 8, Issue 1, pp 21–27 | Cite as

Pin1 levels are downregulated during ER stress in human neuroblastoma cells

  • Yolanda S. Kap
  • Jeroen J. M. Hoozemans
  • Adee J. Bodewes
  • Rob Zwart
  • Onno C. Meijer
  • Frank Baas
  • Wiep Scheper
Original Article

Abstract

Previously, we showed that pretangle neurons in Alzheimer’s disease (AD) brain display unfolded protein stress in the endoplasmic reticulum (ER). Others showed that the peptidylprolyl isomerase Pin1 protects against tangle formation by facilitating tau dephosphorylation, corroborating with the lower expression of Pin1 observed in tangle-bearing neurons. In this study, we investigated Pin1 expression under ER stress conditions. We show that in human, but not mouse neuroblastoma cells, Pin1 is downregulated in response to ER stress, in accordance with the presence of an ER stress response element in the mouse, but not the human Pin1 gene. This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD.

Keywords

Pin 1 Endoplasmic reticulum Alzheimer’s disease Unfolded protein response 

Notes

Acknowledgements

We thank our coworkers at the Neurogenetics Laboratory for their support and Dr. Elly Hol (Netherlands Institute for Brain Research) for the N2a cells. W. S. is supported by a career development grant of the Anton Meelmeijer Center for Translational Research. This work is supported by grant no. CGN05018 from the Hersenstichting Nederland to W. S..

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Yolanda S. Kap
    • 1
  • Jeroen J. M. Hoozemans
    • 2
  • Adee J. Bodewes
    • 1
  • Rob Zwart
    • 1
  • Onno C. Meijer
    • 4
  • Frank Baas
    • 1
    • 3
  • Wiep Scheper
    • 1
  1. 1.Neurogenetics LaboratoryAcademic Medical CenterAmsterdamThe Netherlands
  2. 2.Department of NeuropathologyAcademic Medical CenterAmsterdamThe Netherlands
  3. 3.Department of NeurologyAcademic Medical CenterAmsterdamThe Netherlands
  4. 4.Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical CenterLeiden UniversityLeidenThe Netherlands

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