Neurogenetics

, Volume 6, Issue 4, pp 217–224 | Cite as

Familial risks for migraine and other headaches among siblings based on hospitalizations in Sweden

  • Kari Hemminki
  • Xinjun Li
  • Sven-Erik Johansson
  • Kristina Sundquist
  • Jan Sundquist
Original Article

Abstract

Migraine and other headaches are common disabling conditions, reducing the quality of life in the affected individuals. The unambiguous definition of familial risk for subtypes of migraine and other headaches will advance the search for the heritable causes of these conditions and their underlying mechanisms. We aim at defining familial risks for siblings to be hospitalized because of migraine or other headaches. An ad hoc migraine database was constructed by linking the Multigeneration Register on 0- to 69-year-old siblings to the Hospital Discharge Register for data on migraines of all hospitalized patients in Sweden from years 1987 to 2001. Standardized incidence ratios (SIRs) were calculated for affected sibling pairs by comparison with those whose siblings had no migraine. Among a total of 14,123 hospitalized patients, 205 affected siblings were identified, with a familial SIR of 2.84. SIRs for migraine with and without aura were 3.08 and 2.67, respectively. The highest familial risk of 3.71 was noted for unspecified migraine. The risk tended to be higher for concordant (both siblings sharing the migraine subtype, ranging from 4.0 to 6.0) than discordant subtypes, but even many discordant SIRs were significant. The SIR for spouse correlation was 1.14 for husbands and 1.22 for wives, far from being significant. All subtypes of hospitalized migraines and other headaches show an increased familial risk, at least in specific age groups. The different subtypes appear to share susceptibility, which may imply common disease mechanisms.

Keywords

Sibling risks Heritability Familial aggregation National database 

Notes

Acknowledgements

The registers used in the present study are maintained at Statistics Sweden and the National Board of Health and Welfare. This work was supported by the National Institutes of Health (grant R01-H271084-1), the Swedish Research Council (grant K2001-27X-11651-06C), and the Swedish Council for Working Life and Social Research (grant 2001-2373).

References

  1. 1.
    Ferrari M (1998) Migraine. Lancet 351:1043–1051CrossRefPubMedGoogle Scholar
  2. 2.
    Ropper A, Brown R (2005) Adams and Victor's principles of neurology, 8th edn. McGraw-Hill, New YorkGoogle Scholar
  3. 3.
    Breslau N, Rasmussen B (2001) The impact of migraine: epidemiology, risk factors, and co-morbidities. Neurology 56:S4–S12PubMedGoogle Scholar
  4. 4.
    Mulder EJ, Van Baal C, Gaist D, Kallela M, Kaprio J, Svensson DA, Nyholt DR, Martin NG, MacGregor AJ, Cherkas LF, Boomsma DI, Palotie A (2003) Genetic and environmental influences on migraine: a twin study across six countries. Twin Res 6:422–431CrossRefPubMedGoogle Scholar
  5. 5.
    Lyngberg AC, Rasmussen BK, Jorgensen T, Jensen R (2005) Incidence of primary headache: a Danish epidemiologic follow-up study. Am J Epidemiol 161:1066–1073CrossRefPubMedGoogle Scholar
  6. 6.
    Lyngberg AC, Rasmussen BK, Jorgensen T, Jensen R (2005) Has the prevalence of migraine and tension-type headache changed over a 12-year period? A Danish population survey. Eur J Epidemiol 20:243–249CrossRefPubMedGoogle Scholar
  7. 7.
    Wessman M, Kaunisto MA, Kallela M, Palotie A (2004) The molecular genetics of migraine. Ann Med 36:462–473CrossRefPubMedGoogle Scholar
  8. 8.
    Svensson DA, Larsson B, Waldenlind E, Pedersen NL (2003) Shared rearing environment in migraine: results from twins reared apart and twins reared together. Headache 43:235–244CrossRefPubMedGoogle Scholar
  9. 9.
    Ulrich V, Gervil M, Kyvik KO, Olesen J, Russell MB (1999) Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. Ann Neurol 45:242–246CrossRefPubMedGoogle Scholar
  10. 10.
    Gervil M, Ulrich V, Kaprio J, Olesen J, Russell MB (1999) The relative role of genetic and environmental factors in migraine without aura. Neurology 53:995–999PubMedGoogle Scholar
  11. 11.
    Russell MB, Olesen J (1995) Increased familial risk and evidence of genetic factor in migraine. Br Med J 311:541–544Google Scholar
  12. 12.
    Kallela M, Wessman M, Havanka H, Palotie A, Farkkila M (2001) Familial migraine with and without aura: clinical characteristics and co-occurrence. Eur J Neurol 8:441–449CrossRefPubMedGoogle Scholar
  13. 13.
    Gervil M, Ulrich V, Kaprio J, Russell MB (2001) Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. Eur J Neurol 8:231–235CrossRefPubMedGoogle Scholar
  14. 14.
    Cologno D, De Pascale A, Manzoni GC (2003) Familial occurrence of migraine with aura in a population-based study. Headache 43:231–234CrossRefPubMedGoogle Scholar
  15. 15.
    Noble-Topham SE, Cader MZ, Dyment DA, Rice GP, Brown JD, Ebers GC (2003) Genetic loading in familial migraine with aura. J Neurol Neurosurg Psychiatry 74:1128–1130CrossRefPubMedGoogle Scholar
  16. 16.
    Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D et al (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543–552CrossRefPubMedGoogle Scholar
  17. 17.
    De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, Ballabio A, Aridon P, Casari G (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33:192–196CrossRefPubMedGoogle Scholar
  18. 18.
    Kors EE, Vanmolkot KR, Haan J, Frants RR, van den Maagdenberg AM, Ferrari MD (2004) Recent findings in headache genetics. Curr Opin Neurol 17:283–288CrossRefPubMedGoogle Scholar
  19. 19.
    Estevez M, Gardner KL (2004) Update on the genetics of migraine. Hum Genet 114:225–235CrossRefPubMedGoogle Scholar
  20. 20.
    Lea RA, Nyholt DR, Curtain RP, Ovcaric M, Sciascia R, Bellis C, Macmillan J, Quinlan S, Gibson RA, McCarthy LC, Riley JH, Smithies YJ et al (2005) A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. Neurogenetics 6:67–72CrossRefPubMedGoogle Scholar
  21. 21.
    Thomsen LL, Olesen J, Russell MB (2003) Increased risk of migraine with typical aura in probands with familial hemiplegic migraine and their relatives. Eur J Neurol 10:421–427PubMedCrossRefGoogle Scholar
  22. 22.
    Hemminki K, Li X, Plna K, Granström C, Vaittinen P (2001) The nation-wide Swedish Family-Cancer Database: updated structure and familial rates. Acta Oncol 40:772–777CrossRefPubMedGoogle Scholar
  23. 23.
    Hemminki K, Li X (2004) Familial risks of cancer as a guide to gene identification and mode of inheritance. Int J Cancer 110:291–294CrossRefPubMedGoogle Scholar
  24. 24.
    Hemminki K, Li X, Czene K (2004) Familial risk of cancer: data for clinical counseling and cancer genetics. Int J Cancer 108:109–114CrossRefPubMedGoogle Scholar
  25. 25.
    Hemminki K, Rawal R, Chen B, Lorenzo Bermejo J (2004) Genetic epidemiology of cancer: from families to heritable genes. Int J Cancer 111:944–950CrossRefPubMedGoogle Scholar
  26. 26.
    Hemminki K, Vaittinen P, Dong C, Easton D (2001) Sibling risks in cancer: clues to recessive or X-linked genes? Br J Cancer 84:388–391CrossRefPubMedGoogle Scholar
  27. 27.
    Rasmussen BK, Jensen R, Olesen J (1992) Impact of headache on sickness absence and utilisation of medical services: a Danish population study. J Epidemiol Community Health 46:443–446PubMedCrossRefGoogle Scholar
  28. 28.
    Lichtenstein P, Holm N, Verkasalo P, Illiado A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer. N Engl J Med 343:78–85CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Kari Hemminki
    • 1
    • 2
  • Xinjun Li
    • 3
  • Sven-Erik Johansson
    • 3
  • Kristina Sundquist
    • 3
  • Jan Sundquist
    • 3
  1. 1.Division of Molecular Genetic EpidemiologyGerman Cancer Research Center (DKFZ)HeidelbergGermany
  2. 2.Department of Biosciences at NovumKarolinska InstituteHuddingeSweden
  3. 3.Department of Family Medicine StockholmKarolinska InstituteHuddingeSweden

Personalised recommendations