Neurogenetics

, Volume 4, Issue 4, pp 221–222 | Cite as

Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis

  • Ammar Al-Chalabi
  • Valerie K. Hansen
  • Claire L. Simpson
  • Jing Xi
  • Betsy A. Hosler
  • John F. Powell
  • Diane McKenna-Yasek
  • Christopher E. Shaw
  • P. Nigel Leigh
  • Robert H. BrownJr
Letter to the Editor

Keywords

Amyotrophic lateral sclerosis ALS2 gene Alsin Association study DNA pooling 

References

  1. 1.
    Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (published erratum appears in Nature 1993 364:362). Nature 362:59–62PubMedGoogle Scholar
  2. 2.
    Suthers G, Laing N, Wilton S, Dorosz S, Waddy H (1994) "Sporadic" motoneuron disease due to familial SOD1 mutation with low penetrance. Lancet 344:1773–1773PubMedGoogle Scholar
  3. 3.
    Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE (1997) Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. Ann Neurol 42:803–807PubMedGoogle Scholar
  4. 4.
    Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH, Jr., Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (2001) A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet 29:166–173CrossRefPubMedGoogle Scholar
  5. 5.
    Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben Hamida M, Pericak-Vance M, Hentati F, Siddique T (2001) The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 29:160–165CrossRefPubMedGoogle Scholar
  6. 6.
    Barcellos LF, Klitz W, Field LL, Tobias R, Bowcock AM, Wilson R, Nelson MP, Nagatomi J, Thomson G (1997) Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet 61:734–747PubMedGoogle Scholar
  7. 7.
    Xie X, Ott J (1993) Testing linkage disequilibrium between a disease gene and marker loci. Am J Hum Genet 53:1107–1107PubMedGoogle Scholar
  8. 8.
    Sham PC, Curtis D (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97–105PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Ammar Al-Chalabi
    • 1
    • 2
  • Valerie K. Hansen
    • 2
  • Claire L. Simpson
    • 2
  • Jing Xi
    • 1
  • Betsy A. Hosler
    • 1
  • John F. Powell
    • 3
  • Diane McKenna-Yasek
    • 1
  • Christopher E. Shaw
    • 2
    • 4
  • P. Nigel Leigh
    • 2
  • Robert H. BrownJr
    • 1
  1. 1.Cecil B. Day Laboratory for Neuromuscular ResearchMassachusetts General HospitalCharlestownUSA
  2. 2.Department of Neurology, Institute of PsychiatryKing's College LondonUK
  3. 3.Department of Neuroscience, Institute of PsychiatryKing's College LondonUK
  4. 4.Department of Medical and Molecular GeneticsGuy's King's and St Thomas' School of MedicineLondonUK

Personalised recommendations