Abstract
We investigated morphological changes of the arterial system in the kidneys under prolonged, continuous-flow left heart bypass. After 2 weeks of pulsatile left heart bypass in 12 goats, continuous-flow left heart bypass was conducted for the next 4 weeks. After autopsy, the kidneys were subjected to pathological evaluation. The media of the afferent arterioles were frequently thickened by increased quantities of mature smooth muscle cells (SMC). The juxtaglomerular areas (JGA) were expanded due to increases in the number and size of SMCs and/or SMC-like cells. We speculate that prolonged continuous-flow left heart bypass causes SMCs and/or SMC-like cells to proliferate in the media and perivascular tissue of the afferent arterioles.
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Received: November 28, 2001 / Accepted: May 30, 2002
Acknowledgments We are grateful to Dr. Tsutomu Kasugai of the Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, for his valuable advice. This work was financially supported, in part, by a Grant for Research on Advanced Medical Technology from the Ministry of Health, Labor and Welfare of Japan, and by a Grant-in-Aid for Scientific Research from the Ministry of Education of Japan (No. 13470280).
This paper was presented in part at the 31st annual meeting of the Japanese Society for Cardiovascular Surgery, held at Ube on February 7–9, 2001
Correspondence to:H. Ohnishi
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Ohnishi, H., Nishinaka, T., Tatsumi, E. et al. Proliferative changes in the media of the afferent arterioles under prolonged continuous-flow left heart bypass. J Artif Organs 5, 0204–0207 (2002). https://doi.org/10.1007/s100470200038
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DOI: https://doi.org/10.1007/s100470200038