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Evaluation of graft anastomosis using time–intensity curves and quantitative near-infrared fluorescence angiography during peripheral arterial bypass grafting

  • Masaki YamamotoEmail author
  • Hitoshi Ninomiya
  • Miwa Tashiro
  • Takayuki Sato
  • Takemi Handa
  • Keiji Inoue
  • Kazumasa Orihashi
  • Kazuhiro Hanazaki
Original Article Others
  • 31 Downloads

Abstract

Near-infrared fluorescence angiography (NIR) visualizes blood perfusion using the fluorescence property of indocyanine green (ICG). This study aimed to retrospectively determine the usefulness of a quantitative analysis using NIR to predict the patency of peripheral arterial bypass grafts by measuring their fluorescence luminance intensities (FLIs).

Thirteen grafts in 11 patients who underwent peripheral arterial bypass grafting were divided into a patent graft group (n = 7) and a failed graft group (n = 6). The changes in the FLIs of ICG opacification through the graft and distal host artery were retrospectively analyzed using stored NIR data. The time–intensity curves (TICs) of ICG opacification through the graft (Qgraft) and distal host artery (Qdistal) were measured. Two parameters, Δ(QgraftQdistal) and integral(QgraftQdistal), were also analyzed.

Although not significant, decreases in Qgraft were observed in the failed graft groups. The Qdistal of the failed graft group was significantly attenuated as compared with that of the patent graft group. Δ(QgraftQdistal) increased only in the failed graft group, which indicates widening of the gap in FLI. Integral(QgraftQdistal) was higher in the failed graft group, as it reflects the accumulation of ICG opacification.

The TICs were influenced by anastomotic stenosis in the distal site of the host arteries. Our results indicate that the comparison of Δ(QgraftQdistal) and integral (QgraftQdistal) quantitatively analyzed using NIR can potentially predict anastomotic stenosis.

Keywords

Peripheral arterial bypass graft Near-infrared fluorescence angiography Indocyanine green 

Notes

Acknowledgements

This research was supported by the JSPS KAKENHI (Grant number 20437718) and Fujita Memorial Fund for Medical Research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10047_2018_1083_MOESM1_ESM.tif (1.6 mb)
Supplementary material 1 TICs described from graft no. 10. The TICs were measured from the graft and distal host artery. FLI: fluorescence luminance intensity (TIF 1655 KB)

Supplementary material 2 Near-infrared fluorescence angiographic image. The ICG opacification of the graft and posterior tibial artery (PTA) are shown (graft no. 1 of Table 2) (MPG 7836 KB)

Supplementary material 3 Near-infrared fluorescence angiographic image. The ICG opacification of the graft and posterior tibial artery (PTA) are shown (graft no. 8 of Table 2) (MPG 7460 KB)

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Copyright information

© The Japanese Society for Artificial Organs 2018

Authors and Affiliations

  • Masaki Yamamoto
    • 1
    • 2
    • 3
    Email author
  • Hitoshi Ninomiya
    • 4
    • 5
  • Miwa Tashiro
    • 2
  • Takayuki Sato
    • 3
    • 6
  • Takemi Handa
    • 2
  • Keiji Inoue
    • 3
    • 7
  • Kazumasa Orihashi
    • 2
    • 3
  • Kazuhiro Hanazaki
    • 1
    • 3
    • 8
  1. 1.Department of Operating ManagementKochi Medical School, Kochi UniversityNankokuJapan
  2. 2.Department of Surgery 2Kochi Medical School, Kochi UniversityNankokuJapan
  3. 3.Center for Photodynamic MedicineKochi Medical School, Kochi UniversityNankokuJapan
  4. 4.Integrated Centre for Advanced Medical TechnologiesKochi Medical School, Kochi UniversityNankokuJapan
  5. 5.Faculty of Science and Engineering, Department of Civil and Environmental EngineeringToyo UniversityKawagoeJapan
  6. 6.Department of Cardiovascular ControlKochi Medical School, Kochi UniversityNankokuJapan
  7. 7.Department of UrologyKochi Medical School, Kochi UniversityNankokuJapan
  8. 8.Department of Surgery 1Kochi Medical School, Kochi UniversityNankokuJapan

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