Journal of Artificial Organs

, Volume 19, Issue 3, pp 289–292 | Cite as

Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

  • Ko SakatsumeEmail author
  • Masatoshi Akiyama
  • Kenki Saito
  • Shunsuke Kawamoto
  • Hisanori Horiuchi
  • Yoshikatsu SaikiEmail author
Case Report Artificial Heart (Clinical)


A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.


Ventricular assist device Bleeding tendency Von Willebrand factors Acquired von Willebrand syndrome 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Japanese Society for Artificial Organs 2016

Authors and Affiliations

  1. 1.Division of Cardiovascular SurgeryTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of Molecular and Cellular BiologyInstitute of Development, Aging, and Cancer, Tohoku UniversitySendaiJapan

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