Journal of Artificial Organs

, Volume 18, Issue 3, pp 257–263 | Cite as

Effects of increased surface coverage of polyvinylpyrrolidone over a polysulfone hemofilter membrane on permeability and cell adhesion during continuous hemofiltration

  • Kenichi KokuboEmail author
  • Yoshitaka Kurihara
  • Hiroshi Tsukao
  • Naoko Maruyama
  • Kozue Kobayashi
  • Toshihiro Shinbo
  • Minoru Hirose
  • Hirosuke Kobayashi
Original Article Artificial Kidney / Dialysis


The purpose of the present study was to evaluate the adhesiveness of blood cells and the solute removal performance change of modified polysulfone membranes which have increased polyvinylpyrrolidone (PVP) coverage over their surface. Continuous hemofiltration (CHF) experiments for 24 h were carried out using an ex vivo hemofilter evaluation system to compare a modified polysulfone hemofilter (SHG) with the conventional polysulfone hemofilter (SH). The 25 and 50 % cutoff values of the sieving coefficient of dextran after CHF and the protein concentration in the filtrate was higher in SHG, indicating that less fouling occurred in the SHG membrane. Adhesion of blood cells after 24 h of CHF was significantly higher in the case of SH than in the case of SHG. Blood cell adhesion and membrane fouling were reduced with the use of a polysulfone membrane modified with increased PVP coverage over the surface.


Continuous hemofiltration Polyvinylpyrrolidone Sieving coefficient Cell adhesion 



The authors thank Hidetoshi Kozawa, Makiko Miyata and Hisako Miyazaki of Medical devices Department, Toray Industry Inc. and Hiroyuki Sugaya and Yoshiyuki Ueno of Advanced Material Research Labs, Toray Industry Inc. for their technical assistance and useful discussion regarding this study.

Conflict of interest

H. Kobayashi and K. Kokubo received research grants from Toray Industry Inc. and Toray Medical Co., Ltd. The other authors declare that they have no conflict of interest.


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Copyright information

© The Japanese Society for Artificial Organs 2015

Authors and Affiliations

  • Kenichi Kokubo
    • 1
    • 2
    Email author
  • Yoshitaka Kurihara
    • 1
  • Hiroshi Tsukao
    • 1
  • Naoko Maruyama
    • 1
    • 3
  • Kozue Kobayashi
    • 1
    • 2
  • Toshihiro Shinbo
    • 2
  • Minoru Hirose
    • 1
    • 2
  • Hirosuke Kobayashi
    • 1
    • 2
  1. 1.Kitasato University Graduate School of Medical SciencesSagamiharaJapan
  2. 2.Kitasato University School of Allied Health SciencesSagamiharaJapan
  3. 3.Faculty of Health and Medical CareSaitama Medical UniversitySaitamaJapan

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