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Journal of Artificial Organs

, Volume 17, Issue 4, pp 373–377 | Cite as

Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance

  • Satoru KishimotoEmail author
  • Kazuma Date
  • Mamoru Arakawa
  • Yoshiaki Takewa
  • Takashi Nishimura
  • Tomonori Tsukiya
  • Toshihide Mizuno
  • Nobumasa Katagiri
  • Yukihide Kakuta
  • Daisuke Ogawa
  • Motonobu Nishimura
  • Eisuke Tatsumi
Brief Communication Artificial Heart (Basic)

Abstract

We developed a novel controller for a continuous-flow left ventricular assist device (EVAHEART) that can change the pump’s rotational speed (RS) in synchronization with a patient’s myocardial electrocardiogram (ECG) with the aim of facilitating cardiac recovery. We previously presented various applications of this system in animal models, but there remained a concern that the repeated acceleration and deceleration of the impeller may induce additional hemolysis. In this study, we evaluated the blood trauma and motor power consumption induced by our system in a mock circulation. We evaluated our system with a 60-bpm pulse frequency and a variance between the high and low RSs of 500 rpm (EVA-P; n = 4). The continuous modes of EVAHEART (EVA-C; n = 4) and ROTAFLOW (n = 4) were used as controls. The pumps were examined at a mean flow rate of 5.0 ± 0.2 L/min against a mean pressure head of 100 ± 3 mmHg for a 4-h period. As a result, the normalized indexes of the hemolysis levels of EVA-P and EVA-C were 0.0023 ± 0.0019 and 0.0023 ± 0.0025, respectively, and their difference was not significant. The estimated mean motor power consumptions of EVA-C and EVA-P were 6.24 ± 0.33 and 7.19 ± 0.93 W, respectively. When a novel ECG-synchronized RS-change system was applied to EVAHEART, the periodic RS change with a 500-rpm RS variance did not affect the hemolysis at a 60-bpm pulse frequency.

Keywords

Hemolytic performance Implantable left ventricular assist devices Pulsatile flow EVAHEART Electrocardiogram-synchronized rotational-speed-change system 

Notes

Conflict of interests

The authors have no conflicts of interest to disclose.

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Copyright information

© The Japanese Society for Artificial Organs 2014

Authors and Affiliations

  • Satoru Kishimoto
    • 1
    • 2
    Email author
  • Kazuma Date
    • 1
  • Mamoru Arakawa
    • 3
  • Yoshiaki Takewa
    • 1
  • Takashi Nishimura
    • 4
  • Tomonori Tsukiya
    • 1
  • Toshihide Mizuno
    • 1
  • Nobumasa Katagiri
    • 1
  • Yukihide Kakuta
    • 1
  • Daisuke Ogawa
    • 5
  • Motonobu Nishimura
    • 2
  • Eisuke Tatsumi
    • 1
  1. 1.Department of Artificial OrgansNational Cerebral and Cardiovascular Center Research InstituteOsakaJapan
  2. 2.Department of Organ Regeneration Surgery, Division of SurgeryUniversity of TottoriTottoriJapan
  3. 3.Department of Cardiovascular Surgery, Saitama Medical CenterJichi Medical UniversitySaitamaJapan
  4. 4.Department of Cardiovascular SurgeryTokyo Metropolitan Geriatric HospitalTokyoJapan
  5. 5.Sun Medical Technology Research CorporationNaganoJapan

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