Journal of Artificial Organs

, Volume 15, Issue 1, pp 26–31 | Cite as

Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer

  • Mitsuo Miyazawa
  • Masayasu Aikawa
  • Katsuya Okada
  • Yasuko Toshimitsu
  • Kojun Okamoto
  • Isamu Koyama
  • Yoshito Ikada


With the widespread adoption of laparoscopic cholecystectomy and living-donor liver transplantation in recent years, complications involving the biliary system, stenosis in particular, are increasing. Various invasive and non-invasive techniques are now available for the treatment of biliary stenosis, but all are compromised by a high risk of recurrence and other problems. As a potential solution, our group has developed a bioabsorbable polymer (BAP) tube for implantation as a bypass graft. In the study reported here, we implanted this BAP tube and confirmed bile duct regeneration at the graft site after the tube had been degraded and absorbed into the body. We briefly describe our findings on extrahepatic biliary tissue regeneration, focusing on the possibility of its clinical application. This artificial bile duct may promote the development of novel treatments for biliary disease.


Artificial bile duct Tissue engineering Bioabsorbable polymer Bile duct regeneration 


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Copyright information

© The Japanese Society for Artificial Organs 2011

Authors and Affiliations

  • Mitsuo Miyazawa
    • 1
  • Masayasu Aikawa
    • 1
  • Katsuya Okada
    • 1
  • Yasuko Toshimitsu
    • 1
  • Kojun Okamoto
    • 1
  • Isamu Koyama
    • 1
  • Yoshito Ikada
    • 2
  1. 1.Department of Surgery, Gastrointestinal CenterSaitama Medical University International Medical CenterHidakaJapan
  2. 2.Division of Life ScienceNara Medical UniversityNaraJapan

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