The image reconstruction for fluorescence molecular tomography via a non-uniform mesh

  • Bin Wang
  • Pu Jiao
  • Huangjian YiEmail author
  • Xin Cao
  • Fengjun Zhao
  • Yuqing Hou
  • Xiaowei HeEmail author
Regular Paper


As an optical molecular imaging modality, fluorescence molecular tomography (FMT) can monitor the activities of organisms in vivo at the molecular and cellular levels. However, the recovered image quality is affected by mesh voxel when the finite element method is utilized to recover the fluorescence probe. The target localization is likely to deviate from the actual target under the coarse mesh, but using the fine mesh will increase the number of unknowns, which makes the computational burden heavier and further aggravate the ill-posedness. To solve the problem, a reconstruction strategy using a non-uniform mesh for FMT is developed in this paper. The numerical experiment and physical experiment validated that the strategy is capable and effective for FMT.


Optical molecular imaging Fluorescence molecular tomography Finite element method Non-uniform mesh 


Compliance with ethical standards

Conflict of interest

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled “The image reconstruction for fluorescence molecular tomography via a non-uniform mesh”.


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Copyright information

© The Optical Society of Japan 2019

Authors and Affiliations

  1. 1.School of Information Sciences and TechnologyNorthwest UniversityXi’anChina

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