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Correction by the skin-to-chest wall distance in near-infrared spectroscopy and assessment of breast cancer responses to neoadjuvant chemotherapy

  • Yuko Asano
  • Nobuko YoshizawaEmail author
  • Yukio Ueda
  • Kenji Yoshimoto
  • Tetsuya Mimura
  • Etsuko Ohmae
  • Hiroko Wada
  • Shigeto Ueda
  • Toshiaki Saeki
  • Hiroyuki Ogura
  • Norihiko Shiiya
  • Harumi Sakahara
Regular Paper
  • 12 Downloads

Abstract

Background

The measurement of hemoglobin (Hb) concentrations in breast cancer by near-infrared spectroscopy is useful for the assessment of responses to neoadjuvant chemotherapy (NAC). However, the chest wall muscles may affect this measurement. We corrected Hb concentrations based on the skin-to-chest wall distance. Corrected Hb was compared with uncorrected Hb as a marker of treatment responses in breast cancer patients.

Methods

We measured total Hb (tHb) in breast cancer using a near-infrared time-resolved spectroscopy system in 10 patients before chemotherapy and after the first and second courses of NAC. To assess the skin-to-chest wall distance and thickness of tumors, ultrasound images were obtained using an ultrasonography probe with the spectroscopic probe. Net tHb (tHbnet) was calculated by subtracting tHb in normal breast tissue from cancer tHb. Patients underwent positron emission tomography with [18F] fluorodeoxyglucose (FDG) before chemotherapy and after the second course of NAC. FDG uptake was evaluated using the maximum standardized uptake value (SUVmax).

Results

tHb, tHbnet, and SUVmax in cancer significantly decreased in the course of chemotherapy. The change in tHbnet was larger than that in tHb. Although a correlation was not observed between the change in tHb and that in SUVmax, a positive correlation was noted between the change in tHbnet and that in SUVmax.

Conclusions

Corrections by the skin-to-chest wall distance in spectroscopy led to the change in Hb concentrations being more similar to that in FDG uptake after NAC in breast cancer. tHbnet has potential as a reliable biomarker of breast cancer.

Keywords

Breast cancer Near-infrared time-resolved spectroscopy Hemoglobin Neoadjuvant chemotherapy 

Notes

Acknowledgements

This study was partly supported by JSPS KAKENHI Grant numbers 15K19781, 26282144 and 17H03591.

Compliance with ethical standards

Conflict of interest

S. Ueda has research funding from Hamamatsu Photonics K.K. T. Saeki received honoraria for a speech from Ono Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Novartis Pharma K.K., T. Saeki has research funding from Ono Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Chugai Pharmaceutical Co., Ltd. H. Sakahara has research funding from Hamamatsu Photonics K.K. Y. Ueda, K. Yoshimoto, T. Mimura, E. Ohmae, and H. Wada are employees of Hamamatsu Photonics K.K. No other potential conflict of interest relevant to this article was reported.

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Copyright information

© The Optical Society of Japan 2018

Authors and Affiliations

  • Yuko Asano
    • 1
  • Nobuko Yoshizawa
    • 2
    Email author
  • Yukio Ueda
    • 3
  • Kenji Yoshimoto
    • 3
  • Tetsuya Mimura
    • 3
  • Etsuko Ohmae
    • 3
  • Hiroko Wada
    • 3
  • Shigeto Ueda
    • 4
  • Toshiaki Saeki
    • 4
  • Hiroyuki Ogura
    • 1
  • Norihiko Shiiya
    • 1
  • Harumi Sakahara
    • 2
  1. 1.First Department of SurgeryHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Department of Diagnostic Radiology and Nuclear MedicineHamamatsu University School of MedicineHamamatsuJapan
  3. 3.Central Research Laboratory, Hamamatsu Photonics K.K.HamamatsuJapan
  4. 4.Department of Breast OncologySaitama Medical University International Medical CenterHidakaJapan

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