Optical Review

, Volume 10, Issue 5, pp 466–469

Measurement of Cerebral Optical Pathlength as a Function of Oxygenation Using Near-infrared Time-resolved Spectroscopy in a Piglet Model of Hypoxia

  • Takashi Kusaka
  • Yoshio Hisamatsu
  • Kou Kawada
  • Kensuke Okubo
  • Hitoshi Okada
  • Masanori Namba
  • Tadashi Imai
  • Kenichi Isobe
  • Susumu Itoh
ENVIRONMENTAL, BIOLOGICAL, AND SPACE OPTICS

Abstract

Near-infrared spectroscopy (NIRS) has been used for measurement of changes in cerebral hemoglobin concentrations in neonates to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved reflectance spectroscopy (TRS) were performed in a piglet model with various degrees of cerebral oxygenation to estimate the differential pathlength factor (DPF). A portable three-wavelength TRS system (TRS-10, Hamamatsu Photonics K.K.) with a probe attached to the head of a piglet was used. Eleven newborn piglets were anesthetized and respired by a ventilator to induce stepwise hypoxia loading. The DPF showed positive linear relationship with arterial hemoglobin (Hb) oxygen saturation and sagittal sinus venous Hb oxygen saturation at 761 and 795 nm. The DPF at 835 nm also showed very slight positive linear relationship with arterial hemoglobin oxygen saturation. The DPF values obtained in this study should contribute to a better understanding of noninvasive measurements by NIRS in neonates.

Key words

near-infrared spectroscopy time-resolved reflectance spectroscopy newborn piglets differential pathlength factor hypoxia brain 

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References

  1. 1.
    F. F. Jobsis: Science 198 (1977) 1264.PubMedGoogle Scholar
  2. 2.
    B. Chance, J. S. Leigh, H. Miyake, D. S. Smith, S. Nioka, R. Greenfield, M. Financier, K. Kaufmann, W. Levy, M. Young, P. Cohen, H. Yoshioka and R. Roretsky: Proc. Natl. Acad. Sci. USA 85 (1988) 4971.Google Scholar
  3. 3.
    O. Hazeki and M. Tamura: J. Appl. Physiol. 64 (1988) 796.PubMedGoogle Scholar
  4. 4.
    M. Ferrari, D. A. Wilson, D. F. Hanley, J. F. Hartmann, M. C. Rogers and R. J. Traystman: Am. J. Physiol. 256 (1989) H1493.PubMedGoogle Scholar
  5. 5.
    J. E. Brazy, D. W. Lewis, M. H. Mitnick and F. F. Jobsis: Pediatrics 75 (1985) 217.PubMedGoogle Scholar
  6. 6.
    J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray and E. O. R. Reynolds: Lancet ii (1986) 1063.CrossRefGoogle Scholar
  7. 7.
    A. D. Edwards, J. S. Wyatt, C. Richardson, D. T. Delpy, M. Cope and E. O. R. Reynolds: Lancet ii (1988) 770.CrossRefGoogle Scholar
  8. 8.
    K. D. Liem, J. C. Hopman, B. Oeseburg. A. F. de Haan, C. Festen and L. A. Kollee: Pediatrics 95 (1995) 555.PubMedGoogle Scholar
  9. 9.
    O. Pryds, G. Greisen and B. Fris-Hansen: Pediatr. Res. 27 (1990) 445.PubMedGoogle Scholar
  10. 10.
    F. van Bel, C. A. Dorrepaal, M. J. Benders, P. E. Zeeuwe, M. van de Bor and H. M. Berger: Pediatrics 92 (1993) 365.PubMedGoogle Scholar
  11. 11.
    L. Tyszczuk, J. Meek, C. Elwell and J. S. Wyatt: Pediatrics 102 (1998) 337.CrossRefPubMedGoogle Scholar
  12. 12.
    P. van der Zee, M. Cope, S. R. Arridge, M. Essenpreis, L. A. Potterr, A. D. Edwards, J. S. Wyatt, D. C. McCormick, S. C. Roth, E. O. R. Reynolds and D. T. Delpy: Adv. Exp. Med. Biol. 316 (1992) 143.PubMedGoogle Scholar
  13. 13.
    J. S. Wyatt, M. Cope, D. T. Delpy, P. van der Zee, S. R. Arridge, A. D. Edwards and E. O. R. Reynolds: Dev. Neurosci. 12 (1990) 140.PubMedGoogle Scholar
  14. 14.
    C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope and D. T. Delpy: Pediatr. Res. 39 (1996) 32.PubMedGoogle Scholar
  15. 15.
    M. S. Patterson, B. Chance and B. Wilson: Appl. Optics 289 (1989) 2331.Google Scholar
  16. 16.
    E. Gratton, S. Fantini, M. Franceschini and J. B. Fishkin: Advances in Optical Imaging and Photon Migration, Technical Digest, (Optical Society of America, Washingon, D.C., 1994) p. 212.Google Scholar
  17. 17.
    H. Y. Ma, J. R. Ballesteros, V. Ntziachristos, Q. Zhang and B. Chance: Proc. SPIE. 3597 (1999) 642.Google Scholar
  18. 18.
    M. Oda, Y. Yamashita, T. Nakano, A. Suzuki, K. Shimizu, I. Hirano, F. Shimomura, E. Ohmae, T. Suzuki and T. Tsuchiya: Proc. SPIE 3597 (1999) 611.Google Scholar
  19. 19.
    D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray and J. Wyatt: Phys. Med. Biol. 33 (1988) 1433.CrossRefPubMedGoogle Scholar
  20. 20.
    A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallen, L. Tyszczuk, M. Cope and D. T. Delpy: Pediatr. Res. 39 (1996) 889.PubMedGoogle Scholar
  21. 21.
    K. L Leenders, D. Perani, A. A. Lammertsma, J. D. Heather, P. Buckingham, M. J. Healy, J. M. Gibbs, R. J. Wise, J. Hatazawa, S. Herold, R. P. Beaney, D. J. Brooks, T. Spinks, C. Rhodes, R. S. J. Frackowiak and T. Jones: Brain 113 (1990) 27.PubMedGoogle Scholar
  22. 22.
    B. W. Pogue and M. S. Patterson: Phys. Med. Biol. 39 (1994) 1157.CrossRefPubMedGoogle Scholar
  23. 23.
    G. Zhang, A. Katz, R. R. Alfano, A. D. Kofinas, D. A. Kofinas, P. G. Stubblefield, W. Rosenfeld, D. Beyer, D. Maulik and M. R. Stankovic: Phys. Med. Biol. 45 (2000) 3143.CrossRefPubMedGoogle Scholar
  24. 24.
    A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope and D. T. Delpy: Phys. Med. Biol. 40 (1995) 295.CrossRefPubMedGoogle Scholar

Copyright information

© The Optical Society of Japan 2003

Authors and Affiliations

  • Takashi Kusaka
    • 2
  • Yoshio Hisamatsu
    • 1
  • Kou Kawada
    • 2
  • Kensuke Okubo
    • 1
  • Hitoshi Okada
    • 1
  • Masanori Namba
    • 1
  • Tadashi Imai
    • 1
  • Kenichi Isobe
    • 1
  • Susumu Itoh
    • 1
  1. 1.Department of PediatricsKagawa Medical UniversityKitagun, KagawaJapan
  2. 2.Maternal Perinatal CenterKagawa Medical UniversityKitagun, KagawaJapan

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