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Journal of Human Genetics

, Volume 44, Issue 1, pp 15–17 | Cite as

Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese

  • Fumiyo Murakami
  • T. Shimomura
  • Kazuhiko Kotani
  • Shiro Ikawa
  • Eiji Nanba
  • Kaori Adachi
ORIGINAL ARTICLE

Abstract

We determined polymorphism in the serotonin (5-HT) transporter gene-linked polymorphic region (5-HTTLPR) in 501 healthy Japanese, individuals, using the polymerase chain reaction of Lesch et al., with minor modifications. The distribution of allele frequencies was determined and found to differ from that in Caucasians. We also investigated the relationship of polymorphism in 5-HTTLPR to anxiety traits, by having 189 of the 501 subjects complete a self-rating questionnaire for anxiety and depression. Subjects with the short/short (s/s) genotype had significantly higher anxiety scores than those with the long/long (l/l) or l/s genotype. It is suggested that populations with the s/s genotype of 5-HTTLPR have stronger anxiety-related personality traits than those with the l allele.

Key words Serotonin transporter gene-linked polymorphic region (5-HTTLPR) Healthy Japanese Frequency distribution Anxiety traits SRQ-AD 

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Copyright information

© The Japan Society of Human Genetics and Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Fumiyo Murakami
    • 1
  • T. Shimomura
    • 1
  • Kazuhiko Kotani
    • 2
  • Shiro Ikawa
    • 1
  • Eiji Nanba
    • 3
  • Kaori Adachi
    • 3
  1. 1.Department of Clinical Laboratory Medicine, Tottori University, Faculty of Medicine, Yonago 683-8504, Japan Tel. +81-859-34-8331; Fax +81-859-34-8081 e-mail: toshimo@grape.med.tottori-u.ac.jpJP
  2. 2.Department of Internal Medicine, Akasaki Public Clinic, Akasaki, JapanJP
  3. 3.Gene Research Center, Tottori University, Yonago, JapanJP

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