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Journal of Human Genetics

, Volume 50, Issue 9, pp 435–441 | Cite as

Isolates in a corridor of migrations: a high-resolution analysis of Y-chromosome variation in Jordan

  • Carlos Flores
  • Nicole Maca-Meyer
  • Jose M. Larruga
  • Vicente M. Cabrera
  • Naif Karadsheh
  • Ana M. Gonzalez
Original Article

Abstract

A high-resolution, Y-chromosome analysis using 46 binary markers has been carried out in two Jordan populations, one from the metropolitan area of Amman and the other from the Dead Sea, an area geographically isolated. Comparisons with neighboring populations showed that whereas the sample from Amman did not significantly differ from their Levantine neighbors, the Dead Sea sample clearly behaved as a genetic outlier in the region. Its high R1*-M173 frequency (40%) has until now only been found in northern Cameroonian samples. This contrasts with the comparatively low presence of J representatives (9%), which is the modal clade in Middle Eastern populations, including Amman. The Dead Sea sample also showed a high presence of E3b3a-M34 lineages (31%), which is only comparable to that found in Ethiopians. Although ancient and recent ties with sub-Saharan and eastern Africans cannot be discarded, it seems that isolation, strong drift, and/or founder effects are responsible for the anomalous Y-chromosome pool of this population. These results demonstrate that, at a fine scale, the smooth, continental clines detected for several Y-chromosome markers are often disrupted by genetically divergent populations.

Keywords

Human populations Middle East Jordan Y-chromosome Binary markers 

Notes

Acknowledgements

This work was supported by grants BMC2001-3511 from Spain and COF2002-015 from Gobierno de Canarias to V.M.C.FUNCIS supported C.F and N.M.-M.

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Copyright information

© The Japan Society of Human Genetics and Springer-Verlag 2005

Authors and Affiliations

  • Carlos Flores
    • 1
    • 2
  • Nicole Maca-Meyer
    • 1
    • 2
  • Jose M. Larruga
    • 1
  • Vicente M. Cabrera
    • 1
  • Naif Karadsheh
    • 3
  • Ana M. Gonzalez
    • 1
  1. 1.Departamento de Genética, Facultad de BiologíaUniversidad de La LagunaTenerifeSpain
  2. 2.Unidad de InvestigaciónHospital Universitario N.S. de CandelariaTenerifeSpain
  3. 3.Department of Biochemistry and Physiology, Faculty of MedicineUniversity of JordanAmmanJordan

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