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Hernia

, Volume 18, Issue 4, pp 563–570 | Cite as

Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats

  • C. G. Pereira-lucena
  • R. Artigiani Neto
  • D. T. de Rezende
  • G. de J. Lopes-Filho
  • D. Matos
  • M. M. Linhares
Original Article

Abstract

Purpose

Although meshes reduce abdominal hernia recurrence, they increase the risk of inflammatory complications. This study aimed to compare the early and late postoperative inflammation and collagen deposition responses induced by three meshes.

Methods

Rats were allocated into three groups. In group I, a polypropylene (PP) mesh was implanted in the abdominal wall. In groups II and III, PP + polyglactin (PP + PG) and PP + titanium (PP + TI) meshes were employed, respectively. On the seventh (7th) postoperative day, collagen deposition and inflammation were evaluated, and immunohistochemistry was performed on abdominal wall biopsies. These data were compared with those obtained on the fortieth (40th) postoperative day in a previous study.

Results

The early inflammatory responses were the same in all groups. With time, it decreased in group I (p = 0.047) and increased in group II (p = 0.003). Group I exhibited early elevated VEGF (p < 0.001), COX2 (p < 0.001), and collagen (p = 0.023) levels, and group II exhibited the most severe inflammatory tissue response. On the 40th postoperative day, the VEGF (p < 0.001) and collagen (p < 0.005) were reduced as compared with the 7th postoperative day in all groups.

Conclusions

Belatedly, the inflammatory reaction decreased in PP mesh group and increased in PP + PG mesh group. The PP mesh induced early great elevations in VEGF, COX2 and collagen levels, whereas the PP + PG mesh caused severe tissue inflammation with small elevation in these levels. PP + TI mesh induced inflammatory response levels between the others. In conclusion, the inflammatory response depends on the mesh density and also the mesh material with clinical implications.

Keywords

Hernia Mesh Inflammatory response Collagen VEGF COX2.INFLAMMATORY 

Notes

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

10029_2013_1206_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 13 kb)

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Copyright information

© Springer-Verlag France 2013

Authors and Affiliations

  • C. G. Pereira-lucena
    • 1
    • 2
  • R. Artigiani Neto
    • 1
  • D. T. de Rezende
    • 1
  • G. de J. Lopes-Filho
    • 1
  • D. Matos
    • 1
  • M. M. Linhares
    • 1
  1. 1.Pós-Graduação em Ciência Cirúrgica InterdisciplinarUniversidade Federal de São PauloSão PauloBrazil
  2. 2.Rua Volney Loureiro TavaresAracajuBrazil

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