Pediatric and Developmental Pathology

, Volume 6, Issue 2, pp 156–159

Adenovirus Ascending Cholangiohepatitis

  • Marie-Anne Bründler
  • Norberto Rodriguez-Baez
  • Ron Jaffe
  • Arthur G. Weinberg
  • Beverly Barton Rogers

DOI: 10.1007/s10024-002-0063-4

Cite this article as:
Bründler, MA., Rodriguez-Baez, N., Jaffe, R. et al. Pediatr. Dev. Pathol. (2003) 6: 156. doi:10.1007/s10024-002-0063-4

Three children, two with liver transplants and one with acquired human immunodeficiency virus (HIV) infection, presented with hepatitis accompanied by elevated gamma glutamyl transpeptidase. Biopsies revealed cholangiohepatitis caused by adenovirus infection. There was a progressive loss of interlobular bile ducts in two of the patients. In one patient, infection of the biliary tree was marked by a necrotizing cholangitis, with adenoviral inclusions noted in the biliary epithelium. In each patient, there was evidence of adenovirus gastrointestinal infection. This is the first report of adenoviral infection of the biliary tree in humans. It is hypothesized that adenovirus cholangiohepatitis occurs as a result of ascending infection from the gastrointestinal tract to the biliary tree.

Copyright information

© 2003 Society for Pediatric Patho logy

Authors and Affiliations

  • Marie-Anne Bründler
    • 1
  • Norberto Rodriguez-Baez
    • 2
  • Ron Jaffe
    • 1
  • Arthur G. Weinberg
    • 3
  • Beverly Barton Rogers
    • 3
  1. 1.Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USAUS
  2. 2.Department of Gastroenterology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USAUS
  3. 3.Department of Pathology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USAUS

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