Brain Tumor Pathology

, Volume 36, Issue 1, pp 7–13 | Cite as

The clinicopathological analysis of receptor tyrosine kinases in meningiomas: the expression of VEGFR-2 in meningioma was associated with a higher WHO grade and shorter progression-free survival

  • Satoko NakadaEmail author
  • Yasuo Sasagawa
  • Osamu Tachibana
  • Hideaki Iizuka
  • Nozomu Kurose
  • Akihiro Shioya
  • Xin Guo
  • Sohsuke Yamada
  • Takayuki Nojima
Original Article


WHO grade II/III meningiomas recur frequently and there is currently no established molecular target therapy for meningioma. No previous studies have revealed the association between receptor tyrosine kinases (RTKs) and the recurrence of meningiomas. This study aims to elucidate the association between RTKs and the clinicopathological characteristics and recurrence of meningioma. We investigated the immunohistochemical expression of RTKs (VEGFR-1/2/3, PDGFR-alpha/beta and c-Kit) in 81 meningiomas (WHO grade I, n = 64, WHO grade II/III, n = 17) in 74 patients. Immunohistochemistry revealed that 29 WHO grade I (45%), 10 WHO grade II (77%), and 4 WHO grade III (100%) tumors were VEGFR-2-positive, and that the VEGFR-2 expression was significantly correlated with the WHO grade. In univariate analyses to investigate the clinicopathological factors associated with recurrence, Simpson grade IV/V resection, a larger tumor size, a high VEGFR-2 expression level, WHO grade II/III, a high Ki-67 expression level, and the non-expression of PgR were identified as significant factors. Furthermore, patients with VEGFR-2-positive meningiomas showed significantly shorter progression-free survival. In the multivariate analysis, WHO grade II/III and the location were significantly associated with recurrence. In conclusion, our study suggests that VEGFR-2 inhibitors might be one of the best candidates for molecular therapy against recurrent meningiomas.


Meningioma Recurrence/regrowth WHO grade Receptor tyrosine kinase VEGFR-2 



The authors thank A. Nakayama for her technical assistance. This work was supported by Grant for Promoted Research from Kanazawa Medical University (S2018-8).

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest in association with the present study.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2018

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineKanazawa Medical UniversityUchinadaJapan
  2. 2.Department of Neurosurgery, Medical SchoolKanazawa UniversityKanazawaJapan
  3. 3.Department of NeurosurgeryKanazawa Medical UniversityUchinadaJapan
  4. 4.Department of Orthopedic Surgery, Medical SchoolKanazawa UniversityKanazawaJapan

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