Advertisement

Brain Tumor Pathology

, Volume 33, Issue 1, pp 35–39 | Cite as

Pilomyxoid astrocytomas with rare rosenthal fibers

  • Xiaomei MaEmail author
  • Yin WangEmail author
  • Huimin Liu
  • Hongyu Yu
  • Jin He
Case Report
  • 212 Downloads

Abstract

Pilomyxoid astrocytomas (PMAs) were first officially described in 2007. Since then, intermediate pilomyxoid tumors with histopathological features typical of both PMAs and pilocytic astrocytomas (PAs) have been described. However, we found evidence of tumors that are histologically like PMAs but contain rare Rosenthal fibers, which have been reported in PAs but not in PMAs. We retrospectively analyzed four such cases involving a 16-year-old adolescent with a 3-cm recurring suprasellar tumor, an 11-year-old boy with a nonrecurring 3-cm mass in the left cerebellum, an 18-year-old adolescent with a mass in the suprasellar cistern who died 2 days after total tumor resection, and a 26-year-old woman with a nonrecurring 2-cm mass in the right temporal lobe. Microscopically, the tumors were a monomorphous population of small bipolar cells in a prominent myxoid/mucoid background with rare Rosenthal fibers. The tumor cells infiltrated the adjacent brain parenchyma. Findings for glial fibrillary acidic protein and oligodendrocyte transcription factor were positive, and the Ki-67 protein proliferation index was about 2 %. Our findings document the existence of tumors that are histologically like PMAs but also have Rosenthal fibers. Studies of more such cases are needed for clarification of such tumors’ clinical features.

Keywords

Astrocytoma Pilomyxoid Pilocytic Rosenthal fibers Tumor 

Notes

Acknowledgments

Medical editor Katharine O’Moore-Klopf, ELS (East Setauket, NY, USA) provided professional English-language editing of this article.

References

  1. 1.
    Tihan T, Fisher PG, Kepner JL, Godfraind C, McComb RD, Goldthwaite PT, Burger PC (1999) Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol 58:1061–1068PubMedCrossRefGoogle Scholar
  2. 2.
    Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P, Burger PC (2010) Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol 34:1783–1791PubMedCrossRefGoogle Scholar
  4. 4.
    Forbes JA, Mobley BC, O’Lynnger TM, Cooper CM, Ghiassi M, Hanif R, Pearson MM (2011) Pediatric cerebellar pilomyxoid-spectrum astrocytomas. J Neurosurg Pediatr 8:90–96PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Nakamura OK, Pinho Mda C, Odone Filho V, Rosemberg S (2012) Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings. Einstein (Sao Paulo) 10:236–238CrossRefGoogle Scholar
  6. 6.
    Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH (2008) Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol 21:1345–1356PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2015

Authors and Affiliations

  1. 1.Department of Pathology, Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Division of Neuropathology, Department of PathologyHuashan Hospital of Fudan UniversityShanghaiChina

Personalised recommendations