Brain Tumor Pathology

, Volume 33, Issue 1, pp 57–62 | Cite as

A case of osteoclast-like giant cell-rich epithelioid glioblastoma with BRAF V600E mutation

  • Nobuaki FunataEmail author
  • Sumihito Nobusawa
  • Ryoji Yamada
  • Nobusada Shinoura
Case Report


Epithelioid glioblastomas (E-GBMs) are rare, highly aggressive tumors consisting of closely packed tumor cells with smooth, round cell borders and abundant eosinophilic cytoplasm. They tend to affect younger patients compared with conventional GBM. BRAF V600E mutation is characteristically found in approximately 50 % of all E-GBMs, compared with a low frequency of this mutation in conventional GBM. Here, we report an unusual case of glioma involving the right frontal lobe, basal ganglia and thalamus in an HIV-positive 30-year-old man on antiretroviral therapy. The lesion was composed of abundant discohesive, monotonous epithelioid cells with extensive necrosis, spindle and polyhedral cells, low-grade oligoastrocytoma-like areas, sarcomatous components, and numerous osteoclast-like giant cells (OLGCs) intermingled with epithelioid tumor cells. As the epithelioid cells accounted for more than one-third of the tumor, a pathological diagnosis of E-GBM was made. BRAF V600E mutation was detected in both oligoastrocytoma-like and epithelioid cell components. Similar to previously reported findings on E-GBM associated with low-grade glioma, this case suggested that low-grade astrocytic glioma with BRAF V600E mutation progressed to E-GBM. OLGCs are rarely observed in gliomas, and this is the first case report of E-GBM associated with abundant OLGC infiltration.


Epithelioid glioblastoma BRAF V600E mutation Osteoclast-like giant cells Gliosarcoma 


Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2015

Authors and Affiliations

  • Nobuaki Funata
    • 1
    Email author
  • Sumihito Nobusawa
    • 2
  • Ryoji Yamada
    • 3
  • Nobusada Shinoura
    • 3
  1. 1.Department of PathologyCancer and Infectious Disease Center Tokyo Metropolitan Komagome HospitalTokyoJapan
  2. 2.Department of Human PathologyGunma University Graduate School of MedicineMaebashiJapan
  3. 3.Department of NeurosurgeryCancer and Infectious Disease Center Tokyo Metropolitan Komagome HospitalTokyoJapan

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