Brain Tumor Pathology

, Volume 32, Issue 1, pp 61–65 | Cite as

Effect of boron neutron capture therapy for recurrent anaplastic meningioma: an autopsy case report

  • Hiroshi Kawaji
  • Shin-Ichi Miyatake
  • Kazuya Shinmura
  • Shinji Kawabata
  • Tsutomu Tokuyama
  • Hiroki Namba
Case Report
First Online:
Received:
Accepted:

Abstract

A 70-year-old woman died of systemic metastasis from anaplastic meningioma and underwent autopsy. The patient underwent twice total removal of the right sphenoid ridge meningioma 2 years ago. The tumor recurred 3 times, and then stereotactic radiotherapy was employed. Boron neutron capture therapy (BNCT) was performed for the fourth local recurrence and an additional new lesion. Proliferative activity of the newly developed meningioma, which had been treated with BNCT only, was significantly lower than that of untreated metastatic liver tumor, as well as that of the meningioma specimen obtained at the second surgery. Our pathological findings demonstrated, for the first time, the therapeutic effect of BNCT on anaplastic meningioma at an early stage (2.5 months).

Keywords

Anaplastic meningioma Autopsy Boron neutron capture therapy Bevacizumab Radiation necrosis 
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Notes

Conflict of interest

There is no conflict of interest.

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Copyright information

© The Japan Society of Brain Tumor Pathology 2014

Authors and Affiliations

  • Hiroshi Kawaji
    • 1
  • Shin-Ichi Miyatake
    • 3
  • Kazuya Shinmura
    • 2
  • Shinji Kawabata
    • 3
  • Tsutomu Tokuyama
    • 1
  • Hiroki Namba
    • 1
  1. 1.Department of NeurosurgeryHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Department of Tumor PathologyHamamatsu University School of MedicineHamamatsuJapan
  3. 3.Department of NeurosurgeryOsaka Medical CollegeTakatsukiJapan

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