Brain Tumor Pathology

, Volume 30, Issue 1, pp 45–49 | Cite as

Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping

  • Atsushi IshidaEmail author
  • Makoto Shibuya
  • Takashi Komori
  • Sumihito Nobusawa
  • Kaku Niimura
  • Seigo Matsuo
  • Tomokatsu Hori
Case Report


Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations have been a focus area in glioma research as promising predictors. We report a case of PTPR that was characterized by local recurrence, although subtotal removal and radiotherapy seemed effective for many months. Histological examination showed ependymal features in the surgical specimens. As far as we are aware, this case study is the first to show that the IDH1/2 genotypes in PTPR cells are wild-type genotypes, which is consistent with the negative immunoreactivity that was observed for the IDH1 mutant antibody in this study.


Papillary tumor of the pineal region Ependymal origin Isocitrate dehydrogenase 1 Isocitrate dehydrogenase 2 Third ventricle 



Papillary tumor of the pineal region


Isocitrate dehydrogenase 1/2


Epithelial membrane antigen


Glial fibrillary acidic protein


Subcommissural organ


World Health Organization


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Copyright information

© The Japan Society of Brain Tumor Pathology 2012

Authors and Affiliations

  • Atsushi Ishida
    • 1
    Email author
  • Makoto Shibuya
    • 2
  • Takashi Komori
    • 3
  • Sumihito Nobusawa
    • 4
  • Kaku Niimura
    • 1
  • Seigo Matsuo
    • 1
  • Tomokatsu Hori
    • 1
  1. 1.Department of NeurosurgeryMoriyama Memorial HospitalTokyoJapan
  2. 2.Department of PathologyTokyo Medical University Ibaraki Medical CenterIbarakiJapan
  3. 3.Department of Clinical NeuropathologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  4. 4.Department of PathologyGunma UniversityMaebashiJapan

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