Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings
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- Kitai, R., Hashimoto, N., Yamate, K. et al. Brain Tumor Pathol (2012) 29: 47. doi:10.1007/s10014-011-0064-y
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Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma. We present a case involving a 56-year-old immunocompetent woman who complained of rapid deterioration of her higher brain function over a 4-month period. Magnetic resonance imaging showed extensive white-matter lesions. During brain biopsy, a diffusely infiltrating lymphoma with distinctive immunohistochemical features was detected. Awareness of this unique presentation and early tissue diagnosis provide the best hope for instituting appropriate treatments.