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Brain Tumor Pathology

, 26:73 | Cite as

Successful treatment of neoadjuvant therapy for papillary tumor of the pineal region

  • Hideo NakamuraEmail author
  • Keishi Makino
  • Masato Kochi
  • Yoichi Nakazato
  • Jun-ichi Kuratsu
Original Article

Abstract

We report a boy who in 1994, at the age of 11, presented with headache and vomiting. The fi nal diagnosis was papillary tumor of the pineal region (PTPR). Magnetic resonance imaging (MRI) revealed a heterogeneous mass. Hydrocephalus was addressed by immediate ventricle drainage; subsequently, we attempted tumor removal. As the intraoperative diagnosis of the hemorrhagic tumor was primitive neuroectodermal tumor (PNET), we did not proceed to total removal. After the delivery of radiotherapy (50.4 Gy) and one course of Nimustine hydrochloride (ACNU) chemotherapy, the residual tumor was completely resected. The diagnosis at that time (1994) was papillary pineocytoma. He was followed on an outpatient basis for 15 years and remained free of recurrence. This type of tumor was later proposed to represent a new distinct tumor subtype, papillary tumor of the pineal region (PTPR). Our data indicate that our patient’s tumor should be included in this category.

Key words

Papillary tumor of the pineal region Cytokeratin Neoadjuvant therapy 

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Copyright information

© Japan Soceity of BrainTumor Pathology 2009

Authors and Affiliations

  • Hideo Nakamura
    • 1
    Email author
  • Keishi Makino
    • 1
  • Masato Kochi
    • 2
  • Yoichi Nakazato
    • 3
  • Jun-ichi Kuratsu
    • 1
  1. 1.Department of Neurosurgery, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan
  2. 2.Department of NeurosurgerySan-ai HospitalOitaJapan
  3. 3.Department of Human PathologyGunma University Graduate School of MedicineGunmaJapan

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