Brain Tumor Pathology

, Volume 24, Issue 1, pp 19–23 | Cite as

A rare case of extraventricular neurocytoma

  • Kaori Sakurada
  • Masahiro Akasaka
  • Hideo Kuchiki
  • Makoto Saino
  • Wataru Mori
  • Shinya Sato
  • Yoichi Nakazato
  • Takamasa Kayama
CASE REPORT

Abstract

We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and was treated with gamma-knife radiotherapy. The tumor shrunk transiently, but 7 years later (in 2004), MRI study demonstrated a second recurrence and ventricular dissemination. Partial removal was performed, and histological examination revealed that tumor cells had round or oval nuclei with halos. Frequent mitoses and vascular proliferation were observed. The MIB-1 LI was 80%. Despite postoperative whole-brain radiotherapy to a total dose of 30 Gy, the tumor progressed, and she died at 4 months after the second surgery.

Key words

Extraventricular Neurocytoma Neuroblastoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kleihues, P, Burger, PC, Scheithauser, BW 1993

    Histological typing of tumors of central nervous system, 2nd edn

    World Health Organization international histological classification of tumorsSpringerBerlin
    Google Scholar
  2. 2.
    Nishio, S, Takeshita, I, Kaneko, Y,  et al. 1992Cerebral neurocytoma. A new subset of benign neuronal tumors of the cerebrumCancer (Phila)70529537CrossRefGoogle Scholar
  3. 3.
    Tortori-Donati, P, Fondelli, MP, Rossi, A, Cama, A,  et al. 1999Extraventricular neurocytoma with ganglionic differentiation associated with complex partial seizuresAJNR Am J Neuroradiol20724727PubMedGoogle Scholar
  4. 4.
    Mrak, R, Yasargil, M, Mohapatra, G,  et al. 2004Atypical extraventricular neurocytoma with oligodendroglioma-like spread and an unusual pattern of chromosome 1p and 19q lossHum Pathol3511561159PubMedCrossRefGoogle Scholar
  5. 5.
    Hassoun, J, Gambarelli, D, Grisoli, F,  et al. 1982Central neurocytoma. An electron-microscopic study of two casesActa Neuropathol (Berl)56151156CrossRefGoogle Scholar
  6. 6.
    Yasargil, M, von Ammon, K, von Deimling, ,  et al. 1992Central neurocytoma: histopathological variants and therapeutic approachesJ Neurosurg763237PubMedCrossRefGoogle Scholar
  7. 7.
    Eng, DY, DeMonte, F, Ginsberg, L,  et al. 1997Craniospinal dissemination of central neurocytoma. Report of two casesJ Neurosurg86547552PubMedCrossRefGoogle Scholar
  8. 8.
    Kim, DG, Kim, JS, Chi, JG,  et al. 1996Central neurocytoma: proliferative potential and biological behaviorJ Neurosurg84742747PubMedGoogle Scholar
  9. 9.
    Sgouros, S, Carey, M, Aluwihare, N,  et al. 1998Central neurocytoma: a correlative clinicopathologic and radiologic analysisSurg Neurol49197204PubMedCrossRefGoogle Scholar
  10. 10.
    Kuchiki, H, Kayama, T, Sakurada, K,  et al. 2002Two cases of atypical central neurocytomasBrain Tumor Pathol19105110PubMedCrossRefGoogle Scholar
  11. 11.
    Soylemezoglu, F, Scheithauer, BW, Esteve, J,  et al. 1997Atypical central neurocytomaJ Neuropathol Exp Neurol56551556PubMedGoogle Scholar
  12. 12.
    Horten, BC, Rubinstein, LJ 1976Primary neuroblastoma. A clinicopathological study of 35 casesBrain99735756PubMedCrossRefGoogle Scholar
  13. 13.
    Figarella-Branger, D, Soylemezoglu, F, Kleihues, P,  et al. 2000

    Central neurocytoma

    Kleihues, PCavenee, WK eds. Pathology and genetics of tumors of the central nervous systemIARC PressLyon107111
    Google Scholar
  14. 14.
    Tong, CY, Ng, HK, Pang, JC,  et al. 2000Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomasHistopathology (Oxf)37160165CrossRefGoogle Scholar
  15. 15.
    Brandes, AA, Amista, P, Gardiman, M,  et al. 2000Chemotherapy in patients with recurrent and progressive central neurocytomaCancer (Phila)88169174CrossRefGoogle Scholar
  16. 16.
    Dodds, D, Nonis, J, Mehta, M,  et al. 1997Central neurocytoma: a clinical study of response to chemotherapyJ Neurooncol34279283PubMedCrossRefGoogle Scholar
  17. 17.
    Louis, DN, Swearingen, B, Linggood, RM,  et al. 1990Central nervous system neurocytoma and neuroblastoma in adults – report of eight casesJ Neurooncol9231238PubMedCrossRefGoogle Scholar
  18. 18.
    von Koch, CS, Schmidt, MH, Uyehara-Lock, JH,  et al. 2003The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literatureSurg Neurol60560565PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2007

Authors and Affiliations

  • Kaori Sakurada
    • 1
  • Masahiro Akasaka
    • 1
  • Hideo Kuchiki
    • 1
  • Makoto Saino
    • 1
  • Wataru Mori
    • 1
  • Shinya Sato
    • 1
  • Yoichi Nakazato
    • 2
  • Takamasa Kayama
    • 1
  1. 1.Department of NeurosurgeryYamagata University, School of MedicineYamagataJapan
  2. 2.Department of PathologyGunma University Graduate School of MedicineMaebashiJapan

Personalised recommendations