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Journal of Solid State Electrochemistry

, Volume 23, Issue 11, pp 3153–3164 | Cite as

Blend films based on biopolymers extracted from babassu mesocarp (Orbignya phalerata) for the electrochemical detection of methotrexate antineoplastic drug

  • Handerson Rodrigues Silva Lima
  • Emanuel Airton de Oliveira Farias
  • Paulo Ronaldo Sousa Teixeira
  • Carla EirasEmail author
  • Lívio César Cunha Nunes
Original Paper
  • 26 Downloads

Abstract

Methotrexate (MTX) is an antineoplastic drug widely used in cancer therapies with potentially toxic activity. This paper describes the electrochemical behavior of MTX in ITO (indium tin oxide) electrodes modified with nanostructured films containing biopolymers extracted from babassu mesocarp (BM) (Orbignya phalerata), aiming to develop electrochemical sensors for this drug. After combining PVS (polyvinyl sodium sulfonate) with BM, the analytical sensitivity of the sensor was improved from 2.49 (ITO) to 5.55 μA μmol L−1 (ITO/PVS/BM). The modification of the ITO with the proposed film yielded a detection limit of 5.95 × 10−7 mol L−1 for MTX. The presence of BM in the film considerably increased the sensor roughness as well as the interactions with MTX, which improved the analytical performance of the proposed system. This study demonstrated the possibility of quantifying MTX with electrochemical techniques using natural polymers, which can yield great financial and health benefits.

Keywords

Electrochemical sensor Quantification Antineoplastic Methotrexate 

Notes

Acknowledgments

The authors would like to thank the Federal University of Piauí (UFPI) and Federal Institute of Piauí (IFPI) for providing the research and work facilities.

Funding information

The authors would like to thank the Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq, grant number 001), and Foundation for Research Support of Piauí (FAPEPI) for their financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Handerson Rodrigues Silva Lima
    • 1
  • Emanuel Airton de Oliveira Farias
    • 2
  • Paulo Ronaldo Sousa Teixeira
    • 3
  • Carla Eiras
    • 2
    • 3
    Email author
  • Lívio César Cunha Nunes
    • 1
  1. 1.Núcleo de Tecnologia FarmacêuticaUniversidade Federal do PiauíTeresinaBrazil
  2. 2.Núcleo de Pesquisa em Biodiversidade e BiotecnologiaBIOTEC, Campus de Parnaíba, UFPIParnaíbaBrazil
  3. 3.Laboratório de Pesquisa e Desenvolvimento de Novos Materiais e Sensores MatSens, CT, UFPI, Campus Ministro Petrônio Portela, Teresina-PI, 64049-550, Brazil.Universidade Federal do PiauíTeresinaBrazil

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