Selective determination of L-dopa in the presence of ascorbic acid and uric acid using a 3D graphene foam
- 59 Downloads
Three-dimensional interconnected network graphene foam (GF) was synthesized by chemical vapor deposition. The GF was transferred onto indium tin oxide glass, acting as an electrode for the selective determination of L-dopa in the presence of ascorbic and uric acid. Using differential pulse voltammetry (DPV) method, the oxidation peak current is well linear with L-dopa concentration in the range of 0.05–1 μM with a sensitivity of 2.64 μA μM−1 and in the range of 1–40 μM with a sensitivity of 1.82 μA μM−1. The detection limit of this electrode for L-dopa is about 20 nM. The proposed electrode can also effectively avoid the interference of ascorbic acid and uric acid, making the proposed sensor suitable for the accurate determination of L-dopa in human urine fluids. This electrode will have a wide range of potential application prospect in electrochemical detection.
KeywordsL-dopa Nickel foam Graphene foam Biosensors
This work is supported by the National Natural Science Foundation of China (51201052), Science Funds for the Young Innovative Talents of HUST (201306) and Postdoctoral Initial Founding of Heilongjiang Province (LBH-Q1260, LBH-Q14117).
- 25.Ball EG (1937) Studies on oxidation-reduction XXIII. ascorbic acid. J Biol Chem 118:219–239Google Scholar
- 34.Mazloum-Ardakani M, Rajabi H, Beitollahi H, Mirjalili BF, Akbari A, Taghavinia N (2007) Voltammetric determination of dopamine at the surface of TiO2 nanoparticles modified carbon paste electrode. Int J Electrochem Sci 5:147–157Google Scholar