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Journal of Solid State Electrochemistry

, Volume 22, Issue 9, pp 2681–2689 | Cite as

Nickel oxide nanoparticles decorated graphene quantum dot as an effective electrode modifier for electrocatalytic oxidation and analysis of clozapine

  • A. Shamsi
  • F. Ahour
  • B. Sehatnia
Original Paper
  • 59 Downloads

Abstract

In the present work, a novel, simple, and sensitive clozapine (CLZ) sensor was developed based on nickel oxide nanoparticle (NiO)-decorated graphene quantum dot (GQD)-modified glassy carbon electrode (NiO/GQD/GCE). NiO/GQD/GCE was prepared by simple electrodeposition, the electrochemical behavior of CLZ at the surface of the prepared electrode was studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), and an improved reversibility and increased peak current with negative shift in the oxidation potential were observed at the proposed electrode. The effect of some experimental parameters has been examined, and based on the results, an electron transfer–chemical reaction–electron transfer mechanism has been proposed for CLZ electrooxidation. The differential pulse voltammetric response of the NiO/GQD/GCE was linear to the concentration of CLZ in the range of 3 × 10−9 to 1 × 10−6 M, and the detection limit was found to be 0.55 nM (S/N = 3). The method has been successfully used for the selective determination of the CLZ amount in the pharmaceutical preparations and human serum samples with good accuracy and precision.

Keywords

Clozapine Graphene quantum dot Electrocatalytic oxidation Electrochemical sensor Nickel oxide nanoparticles Differential pulse voltammetry 

Notes

Funding Information

We gratefully acknowledge the partial financial support from the Nanotechnology Research Center and Faculty of Chemistry, Urmia University.

References

  1. 1.
    Kane J, Honigfeld J, Singer H, Meltzer HY (1988) Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45(9):789–796CrossRefGoogle Scholar
  2. 2.
    Casey DE (1998) Effects of clozapine therapy in schizophrenic individuals at risk for tardive dyskinesia. J Clin Psychiatry 59:31–37CrossRefGoogle Scholar
  3. 3.
    Lieberman JA (1998) Maximizing clozapine therapy: managing side effects. J Clin Psychiatry 59:38–43Google Scholar
  4. 4.
    Meltzer HY (1998) Suicide in schizophrenia: risk factors and clozapine treatment. J Clin Psychiatry 59:15–20Google Scholar
  5. 5.
    Zheng MM, Wang ST, Hu WK, Feng YQ (2010) In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma. J Chromatogr A 1217(48):7493–7501CrossRefGoogle Scholar
  6. 6.
    Wohlfarth A, Toepfner N, Hermanns-Clausen M, Auwärter V (2011) Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid–liquid extraction work-up. Anal Bioanal Chem 400(3):737–746CrossRefGoogle Scholar
  7. 7.
    Zhang G, Terry AV Jr, Bartlett MG (2007) Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection. J Chromatogr B 856(1-2):20–28CrossRefGoogle Scholar
  8. 8.
    Shen YL, Wu HL, Ko WK, Wu SM (2002) Simultaneous determination of clozapine, clozapine N-oxide, N-desmethylclozapine, risperidone, and 9-hydroxyrisperidone in plasma by high performance liquid chromatography with ultraviolet detection. Anal Chim Acta 460(2):201–208CrossRefGoogle Scholar
  9. 9.
    Vardakou I, Dona A, Pistos C, Alevisopoulos G, Athanaselis S, Maravelias C, Spiliopoulou C (2010) Validated GC/MS method for the simultaneous determination of clozapine and norclozapine in human plasma. Application in psychiatric patients under clozapine treatment. J Chromatogr B 878(25):2327–2332CrossRefGoogle Scholar
  10. 10.
    Sastry CSP, Rekha TV, Satyanarayana A (1998) Spectrophotometric determination of clozapine in pharmaceuticals. Microchim Acta 128(3-4):201–205CrossRefGoogle Scholar
  11. 11.
    Mohamed AA, Al-Ghannam SM (2004) Spectrophotometric determination of clozapine based on its oxidation with bromate in a micellar medium. Farmaco 59(11):907–911CrossRefGoogle Scholar
  12. 12.
    Hernandez L, Gonzalez E, Hernandez P (1988) Determination of clozapine by adsorptive anodic voltammetry using glassy carbon and modified carbon paste electrodes. Analyst 113(11):1715–1718CrossRefGoogle Scholar
  13. 13.
    Farhadi K, Karimpour A (2007) Electrochemical behavior and determination of clozapine on a glassy carbon electrode modified by electrochemical oxidation. Anal Sci 23(4):479–483CrossRefGoogle Scholar
  14. 14.
    Manjunatha JG, Swamy BEK, Mamatha GP, Gilbert O, Srinivas MT, Sherigara BS (2011) Electrochemical studies of clozapine drug using carbon nanotube-SDS modified carbon paste electrode: a cyclic voltammetry study. Pharma Chem 3:236–249Google Scholar
  15. 15.
    Blankert B, Dominguez O, El Ayyas W, Arcos J, Kauffmann JM (2004) Horseradish peroxidase electrode for the analysis of clozapine. Anal Lett 37(5):903–913CrossRefGoogle Scholar
  16. 16.
    Al Attas AS (2009) Novel PVC membrane selective electrode for the determination of clozapine in pharmaceutical preparations. Int J Electrochem Sci 4:9–19Google Scholar
  17. 17.
    Huang F, Qu S, Zhang S, Liu B, Kong J (2007) Sensitive detection of clozapine using a gold electrode modified with 16-mercaptohexadecanoic acid self-assembled monolayer. Talanta 72(2):457–462CrossRefGoogle Scholar
  18. 18.
    Mashhadizadeh MH, Afshar E (2013) Electrochemical investigation of clozapine at TiO2 nanoparticles modified carbon paste electrode and simultaneous adsorptive voltammetric determination of two antipsychotic drugs. Electrochim Acta 87:816–823CrossRefGoogle Scholar
  19. 19.
    Nigović B, Spajić J (2011) A novel electrochemical sensor for assaying of antipsychotic drug quetiapine. Talanta 86:393–399CrossRefGoogle Scholar
  20. 20.
    Qu S, Pei S, Zhang S, Song P (2013) Preparation of silicate nanotubes and its application for electrochemical sensing of clozapine. Mater Lett 102:10356–10358Google Scholar
  21. 21.
    Shahrokhian S, Kamalzadeh Z, Hamzehloei A (2013) Electrochemical determination of clozapine on MWCNTs/New Coccine doped PPY modified GCE: an experimental design approach. Bioelectrochemistry 90:36–43CrossRefGoogle Scholar
  22. 22.
    Zhao J, Chen GF, Zhu L, Li GX (2011) Graphene quantum dots-based platform for the fabrication of electrochemical biosensors. Electrochem Commun 13(1):31–33CrossRefGoogle Scholar
  23. 23.
    Roushani M, Abdi Z (2014) Novel electrochemical sensor based on graphene quantum dots/riboflavin nanocomposite for the detection of persulfate. Sensors Actuators B Chem 201:503–510CrossRefGoogle Scholar
  24. 24.
    Tan F, Cong L, Li X, Zhao Q, Zhao H, Quan X, Chen J (2016) An electrochemical sensor based on molecularly imprinted polypyrrole/graphene quantum dots composite for detection of bisphenol A in water samples. Sensors Actuators B Chem 233:599–606CrossRefGoogle Scholar
  25. 25.
    Hernandez-Santos D, Gonzalez-Garcia MB, Garcia AC (2002) Metal-nanoparticles based electroanalysis. Electroanalysis 14(18):1225–1235CrossRefGoogle Scholar
  26. 26.
    Katz E, Willner I, Wang J (2004) Electroanalytical and bioelectroanalytical systems based on metal and semiconductor nanoparticles. Electroanalysis 16(12):19–44CrossRefGoogle Scholar
  27. 27.
    Rafiee B, Fakhari AR (2013) Electrocatalytic oxidation and determination of insulin at nickel oxide nanoparticles-multiwalled carbon nanotube modified screen printed electrode. Biosens Bioelectron 46:130–135CrossRefGoogle Scholar
  28. 28.
    El-Khatib KM, Abdel Hameed RM (2011) Development of CuO/carbon Vulcan XC72 as non-enzymatic sensor for glucose determination. Biosens Bioelectron 26(8):3542–3548CrossRefGoogle Scholar
  29. 29.
    Lin KC, Lin YC, Chen SM (2013) A highly sensitive nonenzymatic glucose sensor based on multi-walled carbon nanotubes decorated with nickel and copper nanoparticles. Electrochim Acta 96:164–172CrossRefGoogle Scholar
  30. 30.
    Shamsipur M, Najafi M, Hosseini MR (2010) Highly improved electrooxidation of glucose at a nickel(II) oxide/multi-walled carbon nanotube modified glassy carbon electrode. Bioelectrochemistry 77(2):120–124CrossRefGoogle Scholar
  31. 31.
    Nikahd B, Khalilzadeh MA (2016) Liquid phase determination of bisphenol A in food samples using novel nanostructure ionic liquid modified sensor. J Mol Liq 215:253–257CrossRefGoogle Scholar
  32. 32.
    Yousef Elahi M, Heli H, Bathaie SZ, Mousavi MF (2007) Electrocatalytic oxidation of glucose at a Ni-curcumin modified glassy carbon electrode. J Solid State Electrochem 11:273–282CrossRefGoogle Scholar
  33. 33.
    Noorbakhsh A, Salimi A (2009) Amperometric detection of hydrogen peroxide at nano-nickel oxide/thionine and celestine blue nanocomposite-modified glassy carbon electrodes. Electrochim Acta 54(26):6312–6321CrossRefGoogle Scholar
  34. 34.
    Jafarian M, Forouzandeh F, Danaee I, Gobal F, Mahjani MG (2009) Electrocatalytic oxidation of glucose on Ni and NiCu alloy modified glassy carbon electrode. J Solid State Electrochem 13(8):1171–1179CrossRefGoogle Scholar
  35. 35.
    Ojani R, Raoof JB, Norouzi B (2011) Performance of glucose electrooxidation on Ni–Co composition dispersed on the poly(isonicotinic acid) (SDS) film. J Solid State Electrochem 15(6):1139–1147CrossRefGoogle Scholar
  36. 36.
    Liu BD, Luo LQ, Ding YP, Si XJ, Wei YL, Ouyang XQ, Xu D (2014) Differential pulse voltammetric determination of ascorbic acid in the presence of folic acid at electro-deposited NiO/graphene composite film modified electrode. Electrochim Acta 142:336–342CrossRefGoogle Scholar
  37. 37.
    Cao X, Xu YJ, Wang N (2011) Facile synthesis of NiO nanoflowers and their electrocatalytic performance. Sensors Actuators B Chem 153:434–438CrossRefGoogle Scholar
  38. 38.
    Chekin F, Bagheri S, Arof AK, Bee Abd Hamid S (2012) Preparation and characterization of Ni(II)/polyacrylonitrile and carbon nanotube composite modified electrode and application for carbohydrates electrocatalytic oxidation. J Solid State Electrochem 16(10):3245–3251CrossRefGoogle Scholar
  39. 39.
    Luo L, Li F, Zhu L, Ding Y, Zhang Z, Deng D, Lu B (2013) Nonenzymatic glucose sensor based on nickel (II)oxide/ordered mesoporous carbon modified glassy carbon electrode. Colloids Surf B 102:307–311CrossRefGoogle Scholar
  40. 40.
    Wolfart F, Maciel A, Nagata N, Vidotti M (2013) Electrocatalytical properties presented by Cu/Ni alloy modified electrodes toward the oxidation of glucose. J Solid State Electrochem 17(5):1333–1338CrossRefGoogle Scholar
  41. 41.
    Yi W, Yang D, Chen H, Liu P, Tan J, Li H (2014) A highly sensitive nonenzymatic glucose sensor based on nickel oxide–carbon nanotube hybrid nanobelts. J Solid State Electrochem 18(4):899–908CrossRefGoogle Scholar
  42. 42.
    El-Refaei SM, Saleh MM, Awad MI (2014) Tolerance of glucose electrocatalytic oxidation on NiO x/MnO x/GC electrode to poisoning by halides. J Solid State Electrochem 18(1):5–12CrossRefGoogle Scholar
  43. 43.
    Yu Z, Li H, Zhang X, Liu N, Zhang X (2015) NiO/graphene nanocomposite for determination of H2O2 with a low detection limit. Talanta 144:1–5CrossRefGoogle Scholar
  44. 44.
    Wang L, Tang Y, Wang L, Zhu H, Meng X, Chen Y, Sun Y, Yang XJ, Wan P (2015) Fast conversion of redox couple on Ni(OH)2/C nanocomposite electrode for high-performance nonenzymatic glucose sensor. J Solid State Electrochem 19(3):851–860CrossRefGoogle Scholar
  45. 45.
    Soomro RA, Ibupoto ZH, Sirajuddin AMI, Willander M (2015) Controlled synthesis and electrochemical application of skein-shaped NiO nanostructures. J Solid State Electrochem 19(3):913–922CrossRefGoogle Scholar
  46. 46.
    Fouladgar M, Ahmadzadeh S (2016) Application of a nanostructured sensor based on NiO nanoparticles modified carbon paste electrode for determination of methyldopa in the presence of folic acid. Appl Surf Sci 379:150–155CrossRefGoogle Scholar
  47. 47.
    Li X, Wen H, Fu Q, Peng D, Yu J, Zhang Q, Huang X (2016) Morphology-dependent NiO modified glassy carbon electrode surface for lead(II) and cadmium(II) detection. Appl Surf Sci 363:7–12CrossRefGoogle Scholar
  48. 48.
    Ahour F, Ahsani MK (2016) An electrochemical label-free and sensitive thrombin aptasensor based on graphene oxide modified pencil graphite electrode. Biosens Bioelectron 86:764–769CrossRefGoogle Scholar
  49. 49.
    Ahour F, Shamsi A (2017) Electrochemical label-free and sensitive nanobiosensing of DNA hybridization by graphene oxide modified pencil graphite electrode. Anal Biochem 532:64–71CrossRefGoogle Scholar
  50. 50.
    Ahour F, Taheri M (2018) Anodic stripping voltammetric determination of copper (II) ions at a graphene quantum dot-modified pencil graphite electrode. J Iran Chem Soc 15(2):343–350CrossRefGoogle Scholar
  51. 51.
    Kauffmann J-M, Vire J-C, Patriarche GJ (1979) Electrochemical oxidation of derivatives of dibenzodiazepin, dibenzothiazepin and dibenzoxazepin. Anal Letters 12(11):1217–1234CrossRefGoogle Scholar
  52. 52.
    Arvand M, Ghasempour M (2012) Voltammetric determination of clozapine in pharmaceutical formulations and biological fluids using an in situ surfactant modified carbon ionic liquid electrode. Electroanalysis 24(3):683–690CrossRefGoogle Scholar
  53. 53.
    U.S. FDA Guidance for Industry, Bioanalytical Method Validation, 2001Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Nanotechnology Research Center, Faculty of ScienceUrmia UniversityUrmiaIran

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