Journal of Solid State Electrochemistry

, Volume 16, Issue 9, pp 2907–2911 | Cite as

Efficient electrocatalytic oxidation and selective determination of isoniazid by Fe(tmphen) 3 2+ -exchanged Nafion®-modified electrode

Original Paper


Cyclic voltammetry and electrochemical impedance studies of Fe(tmphen) 3 2+ (where tmphen = 3,4,7,8-tetramethyl-1,10-phenanthroline)-immobilized Nafion®-modified glassy carbon electrode (GC/Nf/Fe(tmphen) 3 2+ ) are carried out in 0.1 M Na2SO4 solution. Nafion–Fe(tmphen) 3 2+ complex exhibits efficient electrocatalytic oxidation of isoniazid. The linear double reciprocal plot of current and concentration of isoniazid shows a Michaelis–Menten-type catalytic process. The catalytic oxidation currents are proportional to the concentration of isoniazid and show a wide linear calibration range for the quantitative determination of isoniazid. Detection limit and sensitivity are found to be 13 μM and 2.5 μA mM−1, respectively.


Nafion® Electrocatalysis Isoniazid oxidation Fe(tmphen)32+ 



Generous funding from DST and CSIR, New Delhi is gratefully acknowledged. We acknowledge Dr. S. Abraham John, Gandhigram Rural University, India, for fruitful discussions. One of the authors, UPA, acknowledges CSIR for SRF.

Supplementary material

10008_2012_1724_MOESM1_ESM.pdf (16 kb)
ESM 1 (PDF 16 kb)


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceBanaras Hindu UniversityVaranasiIndia

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