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Malignant peripheral nerve sheath tumor (MPNST) arising from angiosarcoma: a rare case report

  • Maria Lazaridou
  • Eleni Bourlidou
  • Margarita Vafeiadou
  • Yiannis Papadiochos
  • Nikolaos Barbetakis
  • Anastasia Kiziridou
  • Doxa Mangoudi
Case Report
  • 22 Downloads

Abstract

Purpose

An extremely rare case of divergent differentiation of a cutaneous angiosarcoma to a malignant peripheral nerve sheath tumor (MPNST) is presented.

Methods

A 62-year-old male patient presented with an angiosarcoma of the left buccal region, which was excised with wide surgical margins. Four months after the operation, the tumor recurred locally as a MPNST. The recurrent tumor was treated with surgical excision followed by postoperative radiotherapy. Four years later, the patient presented with solitary lung metastasis. The patient underwent upper right lobectomy.

Results

The patient is alive and disease-free 2 years after the lobectomy and 6 years after initial presentation.

Conclusions

Divergent differentiation of an angiosarcoma to a neurosarcoma supports the theory that cells of the neural crest capable of differentiating both to neuroectoderm and to mesenchyme give origin to these tumors.

Keywords

Malignant peripheral nerve sheath tumor Head and neck sarcoma Angiosarcoma Divergent differentiation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Maria Lazaridou
    • 1
  • Eleni Bourlidou
    • 2
  • Margarita Vafeiadou
    • 3
  • Yiannis Papadiochos
    • 4
  • Nikolaos Barbetakis
    • 5
  • Anastasia Kiziridou
    • 6
  • Doxa Mangoudi
    • 7
  1. 1.ThessalonikiGreece
  2. 2.AthensGreece
  3. 3.Papanikolaou HospitalThessalonikiGreece
  4. 4.Hospital Aglaia KyriakouAthensGreece
  5. 5.Department of Thoracic Surgery“Theagenio” Cancer HospitalThessalonikiGreece
  6. 6.Department of Pathology“Theagenio” Cancer HospitalThessalonikiGreece
  7. 7.Department of Oral and Maxillofacial Surgery “Theagenio” Cancer Hospital (Former)“Theagenio” Cancer HospitalThessalonikiGreece

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