Oral and Maxillofacial Surgery

, Volume 13, Issue 1, pp 21–26 | Cite as

Endodontic surgery with and without inserts of bioactive glass PerioGlas®—a clinical and radiographic follow-up

  • Alexander PantchevEmail author
  • Eva Nohlert
  • Åke Tegelberg
Original Article



This study evaluated the use of bioactive glass, PerioGlas®, after retrograde filling with Super EBA™ cement in the treatment of periapical bone destruction.

Study design

Healing outcomes were followed up after endodontic surgery in 186 teeth. Outcomes were divided into two groups according to follow-up time: short- and long-term. The EBA™ group (n = 110) underwent endodontic surgery and retrograde filling with EBA™ cement. In the EBA™ + PerioGlas® group (n = 76), PerioGlas® was embedded in the bone cavity after retrograde filling.


The success rate in the EBA™ + PerioGlas® group was 72% compared with 56% in the Super EBA™ group at the short-term follow-up and 74% and 84%, respectively, at the long-term follow-up. Healing of periapical bone destruction classified as uncertain at the short-term follow-up was considered successful in two out of three cases at the long-term follow-up.


This study found that PerioGlas® as bone substitute did not significantly improve endodontic healing outcome.


Bone graft evaluation Bone regeneration Endodontic surgery PerioGlas® Retrograde filling 



We thank the Centre for Clinical Research, Uppsala University in Västerås for their support of this project and especially research assistant Petra Wahlén and PhD Andreas Rosenblad for help with the statistical analyzes.


  1. 1.
    Friedman S (1991) Retrograde approaches in endodontic therapy. Endod Dent Traumatol 7:97–107PubMedCrossRefGoogle Scholar
  2. 2.
    Persson G, Lennartsson B, Lundström I (1974) Results of retrograde root-filling with special reference to amalgam and Cavit as root-filling materials. Swed Dent J 8:123–133Google Scholar
  3. 3.
    Rud J, Andreasen JO, Möller Jensen JE (1972) Radiographic criteria for the assessment of healing after endodontic surgery. Int J Oral Surg 1:195–214PubMedCrossRefGoogle Scholar
  4. 4.
    Dorn SO, Gartner AH (1990) Retrograde filling materials: a retrospective success–failure study of amalgam, EBA and IRM. J Endod 16:391–393PubMedCrossRefGoogle Scholar
  5. 5.
    Pantschev A, Carlsson AP, Andersson L (1994) Retrograde root filling with EBA cement or amalgam—a comparative clinical study. Oral Surg Oral Med Oral Pathol 78:101–104PubMedCrossRefGoogle Scholar
  6. 6.
    Johnson MW, Sullivan SM, Rohrer M, Collier M (1997) Regeneration of peri-implant infrabony defects using Perioglas®: a pilot study in rabbits. Int J Oral Maxillofac Implants 12:835–839PubMedGoogle Scholar
  7. 7.
    Shapoff C, Alexander D, Clark A (1997) Compendium in continuing education in dentistry 18 (4):352–363Google Scholar
  8. 8.
    Oonishi H, Kushitani S, Yasukawa E, Iwaki H, Hench LL, Wilson J et al (1997) Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop Relat Res 334:316–325PubMedCrossRefGoogle Scholar
  9. 9.
    Zamet JS, Darbar UR, Griffiths GS, Bulman JS, Bragger U, Burgin W et al (1997) Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects. J Clin Periodontol 24:410–418PubMedCrossRefGoogle Scholar
  10. 10.
    Wilson J, Low SB (1992) Bioactive ceramics for periodontal treatment: comparative studies in the patus monkey. J Appl Biomater 3:123–129PubMedCrossRefGoogle Scholar
  11. 11.
    Froum S, Weinberg MA, Tarnow D (1998) Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study. J Periodontol 69:698–709PubMedGoogle Scholar
  12. 12.
    Allan I, Newman H, Wilson M (2001) Antibacterial activity of Particulate Bioglass® against supra and subgingival bacteria. Biomaterials 22:168CrossRefGoogle Scholar
  13. 13.
    Stoor P, Söderling E, Salonen JI (1998) Antibacterial effects of bioactive glass paste on oral microorganisms. Acta Odontol Scand 56:161–165PubMedCrossRefGoogle Scholar
  14. 14.
    Chong BS, Pitt Ford TR, Hudson MB (2003) A prospective clinical study of Mineral Trioxide Aggregate and IRM when used as root-end filling materials in endodontic surgery. Int Endod J 36:520–526PubMedCrossRefGoogle Scholar
  15. 15.
    Andersson ÖH, Vähätalo K, Yli-Urpo A, Happonen RP, Karlsson KH (1994) Short-term reaction kinetics of bioactive glass in stimulated body fluid and in subcutaneous tissue. Bioceramics, Vol. 7, (Proceedings of the 7th International Symposium on Ceramics in Medicine, Turku, Finland, 1994)Google Scholar
  16. 16.
    Vrouwenvelder WCA, Groot CG, de Groot K (1993) Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxylapatite, titanium alloy, and stainless steel. J Biomed Mater Res 27:465–475PubMedCrossRefGoogle Scholar
  17. 17.
    Nordenram Å (1970) Biobond® for retrograde root filling in apicectomy. Scand J Dent Res 78:251–255PubMedGoogle Scholar
  18. 18.
    Throndson RR, Sexton SB (2002) Grafting mandibular third molar extraction sites: a comparison of bioactive glass to a nongrafted site. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:413–419PubMedCrossRefGoogle Scholar
  19. 19.
    Brooks LT, Melloning JT, Meffert RM, Jones AA, Nummikoski PV, Cochran DL (1998) Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans. J Periodontol 69:1027–1035Google Scholar
  20. 20.
    Maltezos C, Glickman GN, Ezzo P, He J (2006) Comparison of the sealing of resilon, Pro Root MTA, and Super-EBA as root-end filling materials: a bacterial leakage study. J Endod 32:324–327PubMedCrossRefGoogle Scholar
  21. 21.
    Del Fabbro M, Taschieri S, Testori T, Francetti L, Weinstein RL. Surgical versus non-surgical endodontic re-treatment for periradicular lesions. Cochrane Database of Systematic Reviews 2007, Issue 3. Art No.: CD005511. doi: 10.1002/14651858.pub2

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Alexander Pantchev
    • 1
    Email author
  • Eva Nohlert
    • 2
  • Åke Tegelberg
    • 1
    • 2
  1. 1.Department of Oral Rehabilitation/EndodonticsCentral HospitalVästeråsSweden
  2. 2.Centre for Clinical ResearchUppsala University, Central HospitalVästeråsSweden

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