Abstract
The structures and stabilities of 2,2′-diBeX-1,1′-biphenyl (X = H, F, Cl, CN) derivatives and their affinities for F−, Cl−, and CN− were theoretically investigated using a B3LYP/6–311 + G(3df,2p)//B3LYP/6–31 + G(d,p) model. The results obtained show that the 2,2′-diBeX-1,1′-biphenyl derivatives (X = H, F, Cl, CN) exhibit very high F−, Cl−, and CN− affinities, albeit lower than those reported before for their 1,8-diBeX-naphthalene analogs, in spite of the fact that the biphenyl derivatives are more flexible than their naphthalene counterparts. Nevertheless, some of the biphenyl derivatives investigated are predicted to have anion affinities larger than those measured for SbF5, which is considered one of the strongest anion capturers. Therefore, although weaker than their naphthalene analogs, the 2,2′-diBeX-1,1′-biphenyl derivatives can still be considered powerful anion sponges. This study supports the idea that compounds containing –BeX groups in chelating positions behave as anion sponges due to the electron-deficient nature and consequently high intrinsic Lewis acidity of these groups.
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Muller-Dethlefs K, Hobza P (2000) Noncovalent interactions: a challenge for experiment and theory. Chem Rev 100(1):143–167
Karshikoff A (2006) Non-covalent interactions in proteins. World Scientific, Singapore
Riley KE, Pitonak M, Jurecka P, Hobza P (2010) Stabilization and structure calculations for noncovalent interactions in extended molecular systems based on wave function and density functional theories. Chem Rev 110(9):5023–5063
Hobza P, Müller-Dethlefs K (2010) Non-covalent interactions: theory and experiment. Royal Society of Chemistry, Cambridge
Adeli M, Soleyman R, Beiranvand Z, Madani F (2013) Carbon nanotubes in cancer therapy: a more precise look at the role of carbon nanotube–polymer interactions. Chem Soc Rev 42(12):5231–5256
Yan QF, Luo ZY, Cai K, Ma YG, Zhao DH (2014) Chemical designs of functional photoactive molecular assemblies. Chem Soc Rev 43(12):4199–4221
Mahadevi AS, Sastry GN (2016) Cooperativity in noncovalent interactions. Chem Rev 116(5):2775–2825
Rodgers MT, Armentrout PB (2016) Cationic noncovalent interactions: energetics and periodic trends. Chem Rev 116(9):5642–5687
Parrill AL, Lipkowitz KB, DiLabio GA, Otero-de-la-Roza A (2016) Noncovalent interactions in density functional theory (Reviews in Computational Chemistry, vol 29). Wiley, Hoboken
Hermann J, DiStasio RA, Tkatchenko A (2017) First-principles models for van der Waals interactions in molecules and materials: concepts, theory, and applications. Chem Rev 117(6):4714–4758
Ma YG, Politzer P (2004) Electronic density approaches to the energetics of noncovalent interactions. Int J Mol Sci 5(4–7):130–140
Politzer P, Lane P, Concha MC, Ma YG, Murray JS (2007) An overview of halogen bonding. J Mol Model 13(2):305–311
Politzer P, Murray JS, Concha MC (2007) Halogen bonding and the design of new materials: organic bromides, chlorides and perhaps even fluorides as donors. J Mol Model 13(6–7):643–650
Politzer P, Murray JS, Clark T (2010) Halogen bonding: an electrostatically-driven highly directional noncovalent interaction. Phys Chem Chem Phys 12(28):7748–7757
Clark T, Hennemann M, Murray JS, Politzer P (2007) Halogen bonding: the sigma-hole. J Mol Model 13(2):291–296
Politzer P, Murray JS, Lane P (2007) Sigma-hole bonding and hydrogen bonding: competitive interactions. Int J Quant Chem 107(15):3046–3052
Murray JS, Lane P, Politzer P (2009) Expansion of the sigma-hole concept. J Mol Model 15(6):723–729
Kolar MH, Hobza P (2016) Computer modeling of halogen bonds and other sigma-hole interactions. Chem Rev 116(9):5155–5187
Haartz JC, McDaniel DH (1973) Fluoride-ion affinity of some Lewis acids. J Am Chem Soc 95(26):8562–8565
Pflugrath JW, Quiocho FA (1985) Sulfate sequestered in the sulfate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds. Nature 314(6008):257–260
Luecke H, Quiocho FA (1990) High specificity of a phosphate-transport protein determined by hydrogen-bonds. Nature 347(6291):402–406
Stephan H, Gloe K, Schiessl P, Schmidtchen FP (1995) Lipophilic ditopic guanidinium receptors—selective extractants for tetrahedral oxoanions. Supramol Chem 5(4):273–280
Mangani S, Ferraroni M (1997) Natural anion receptors: anion recognition by proteins. In: Bianchi A, Bowman-James K, Garcia-Espafia E (eds) Supramolecular chemistry of anions. Wiley–VCH, Weinheim, pp 63–78
Ihm H, Yun S, Kim HG, Kim JK, Kim KS (2002) Tripodal nitro-imidazolium receptor for anion binding driven by (C-H)(+)-X- hydrogen bonds. Org Lett 4(17):2897–2900
Kang SO, Jeon S, Nam KC (2002) Anion recognition by urea derivatives of anthraquinone: dihydrogen phosphate ion selective neutral receptors. Supramol Chem 14(5):405–410
Guo W, Wang J, He JQ, Li ZC, Cheng JP (2004) Polymethylene-bridged cystine-glycine-containing cyclopeptides as hydrogen-bonding electroneutral anion receptors: design, synthesis, and halide ion recognition. Supramol Chem 16(3):171–174
Zhang Y, Li MX, Lu MY, Yang RH, Liu F, Li KA (2005) Anion chelation-induced porphyrin protonation and its application for chloride anion sensing. J Phys Chem A 109:7442–7448
Melaimi M, Sole S, Chiu CW, Wang HD, Gabbai P (2006) Structural and electrochemical investigations of the high fluoride affinity of sterically hindered 1,8-bis(boryl)naphthalenes. Inorg Chem 45(20):8136–8143
Blondeau P, Segura M, Perez-Fernandez R, de Mendoza J (2007) Molecular recognition of oxoanions based on guanidinium receptors. Chem Soc Rev 36(2):198–210
Caltagirone C, Gale PA, Hiscock JR, Brooks SJ, Hursthouse MB, Light ME (2008) 1,3-Diindolylureas: high affinity dihydrogen phosphate receptors. Chem Commun 26:3007–3009
Caltagirone C, Mulas A, Isaia F, Lippolis V, Gale PA, Light ME (2009) Metal-induced pre-organisation for anion recognition in a neutral platinum-containing receptor. Chem Commun 41:6279–6281
Chen ZH, Amine K (2009) Computational estimates of fluoride affinity of boron-based anion receptors. J Electrochem Soc 156(8):A672–A676
Hudnall TW, Chiu CW, Gabbai FP (2009) Fluoride ion recognition by chelating and cationic boranes. Acc Chem Res 42(2):388–397
Kubik S (2009) Amino acid containing anion receptors. Chem Soc Rev 38(2):585–605
Zhang ZG, Schreiner PR (2009) (Thio)urea organocatalysis—what can be learnt from anion recognition? Chem Soc Rev 38(4):1187–1198
Amendola V, Fabbrizzi L, Mosca L (2010) Anion recognition by hydrogen bonding: urea-based receptors. Chem Soc Rev 39(10):3889–3915
Hong SJ, Yoo J, Yoon DW, Yoon J, Kim JS, Lee CH (2010) Superior anion-binding properties of a cryptand-like oligopyrrolic macrocycle. Chem Asian J 5(4):768–772
Li AF, Wang JH, Wang F, Jiang YB (2010) Anion complexation and sensing using modified urea and thiourea-based receptors. Chem Soc Rev 39(10):3729–3745
Steed JW (2010) Anion-tuned supramolecular gels: a natural evolution from urea supramolecular chemistry. Chem Soc Rev 39(10):3686–3699
Zhao HY, Gabbai FP (2010) A bidentate Lewis acid with a telluronium ion as an anion-binding site. Nat Chem 2(11):984–990
Bergamaschi G, Boiocchi M, Monzani E, Amendola V (2011) Pyridinium/urea-based anion receptor: methine formation in the presence of basic anions. Org Biomol Chem 9(24):8276–8283
Kraft A, Beck J, Krossing I (2011) Facile access to the pnictocenium ions Cp*ECl (+) (E = P, As) and (Cp*)(2)P (+): chloride ion affinity of Al(ORF)(3). Chem Eur J 17(46):12975–12980
Wenzel M, Light ME, Davis AP, Gale PA (2011) Thiourea isosteres as anion receptors and transmembrane transporters. Chem Commun 47(27):7641–7643
Caltagirone C, Bazzicalupi C, Bencini A, Isaia F, Garau A, Lippolis V (2012) Anion recognition properties of pyridine-2,6-dicarboxamide and isophthalamide derivatives containing L-tryptophan moieties. Supramol Chem 24(2):95–100
Baggi G, Boiocchi M, Ciarrocchi C, Fabbrizzi L (2013) Enhancing the anion affinity of urea-based receptors with a Ru(terpy)(2)(2+) chromophore. Inorg Chem 52(9):5273–5283
Zhao HY, Leamer LA, Gabbai FP (2013) Anion capture and sensing with cationic boranes: on the synergy of Coulombic effects and onium ion-centred Lewis acidity. Dalton Trans 42(23):8164–8178
Datta S, Halder M (2014) Effect of encapsulation in the anion receptor pocket of sub-domain IIA of human serum albumin on the modulation of pK(a) of warfarin and structurally similar acidic guests: a possible implication on biological activity. J Photochem Photobiol B Biol 130:76–85
Elmes RBP, Yuen KKY, Jolliffe KA (2014) Sulfate-selective recognition by using neutral dipeptide anion receptors in aqueous solution. Chem Eur J 20(24):7373–7380
Sekutor M, Mlinaric-Majerski K (2014) Adamantyl aminoguanidines as receptors for oxo-anions. Tetrahedron Lett 55(49):6665–6670
Elmes RBP, Jolliffe KA (2015) Anion recognition by cyclic peptides. Chem Commun 51(24):4951–4968
Pandian TS, Kang J (2015) Participation of aliphatic C-H hydrogen bonding in anion recognition. Tetrahedron Lett 56(28):4191–4194
Tepper R, Schulze B, Jager M, Friebe C, Scharf DH, Gorls H, Schubert US (2015) Anion receptors based on halogen bonding with halo-1,2,3-triazoliums. J Org Chem 80(6):3139–3150
Amendola V, Bergamaschi G, Boiocchi M, Fusco N, La Rocca MV, Linati L, Lo Presti E, Mella M, Metrangolo P, Miljkovic A (2016) Novel hydrogen- and halogen-bonding anion receptors based on 3-iodopyridinium units. RSC Adv 6(72):67540–67549
Amendola V, Bergamaschi G, Boiocchi M, Legnani L, Lo Presti E, Miljkovic A, Monzani E, Pancotti F (2016) Chloride-binding in organic–water mixtures: the powerful synergy of C-H donor groups within a bowl-shaped cavity. Chem Commun 52(72):10910–10913
Edwards SJ, Marques I, Dias CM, Tromans RA, Lees NR, Felix V, Valkenier H, Davis AP (2016) Tilting and tumbling in transmembrane anion carriers: activity tuning through n-alkyl substitution. Chem Eur J 22(6):2004–2011
Nehra A, Bandaru S, Yarramala DS, Rao CP (2016) Differential recognition of anions with selectivity towards F− by a calix 6 arene-thiourea conjugate investigated by spectroscopy, microscopy, and computational modeling by DFT. Chem Eur J 22(26):8903–8914
Qi J, Jinghan H, Chen JJ, Sun Y, Li JB (2016) Cyanide detection using azo-acylhydrazone in aqueous media with high sensitivity and selectivity. Curr Anal Chem 12(2):119–123
Wu HW, Chen YY, Rao CH, Liu CX (2016) Anion receptors based on CH donor group. Progr Chem 28(10):1501–1514
Molina P, Zapata F, Caballero A (2017) Anion recognition strategies based on combined noncovalent interactions. Chem Rev 117(15):9907–9972
Kubik S (2010) Anion recognition in water. Chem Soc Rev 39(10):3648–3663
Jenkins HDB, Krossing I, Passmore J, Raabe I (2004) A computational study of SbnF(5n) (n=1-4)—implications for the fluoride ion affinity of nSbF(5). J Fluor Chem 125(11):1585–1592
Li SG, Dixon DA (2006) Molecular and electronic structures, Bronsted basicities, and Lewis acidities of group VIB transition metal oxide clusters. J Phys Chem A 110(19):6231–6244
Brea O, Corral I, Mó O, Yáñez M, Alkorta I, Elguero J (2016) Beryllium-based anion sponges. Close relatives of proton sponges. Chem Eur J 22:18322–18325
Montero-Campillo MM, Corral I, Mó O, Yáñez M, Alkorta I, Elguero J (2017) Beryllium-based fluorenes as efficient anion sponges. Phys Chem Chem Phys 19(34):23052–23059
Christe KO, Dixon DA, McLemore D, Wilson WW, Sheehy JA, Boatz JA (2000) On a quantitative scale for Lewis acidity and recent progress in polynitrogen chemistry. J Fluor Chem 101(2):151–153
Becke AD (1993) A new mixing of Hartree–Fock and local-density-functional theories. J Chem Phys 98(2):1372–1377
Lee C, Yang W, Parr RG (1988) Development of the Colle–Salvetti correlation-energy formula into a functional of the electron density. Phys Rev B 37(2):785–789
Curtiss LA, Redfern PC, Raghavachari K (2007) Gaussian-4 theory. J Chem Phys 126(8):12
Bader RFW (1990) Atoms in molecules. A quantum theory. Clarendon, Oxford
Reed AE, Curtiss LA, Weinhold F (1988) Intermolecular interactions from a natural bond orbital, donor–acceptor viewpoint. Chem Rev 88(6):899–926
Biegler-König F, Schonbohm J, Bayles D (2001) Software news and updates—AIM2000—a program to analyze and visualize atoms in molecules. J Comput Chem 22(5):545–559
Glendening ED, Badenhoop JK, Reed AE, Carpenter JE, Bohmann JA, Morales CM, Weinhold F (2004) NBO6.G. Theoretical Chemistry Institute, University of Wisconsin, Madison. http://www.chem.wisc.edu/~nbo5
Acknowledgements
This work was supported by the projects CTQ2015-63997-C2 and CTQ2013-43698-P of the Ministerio de Economía y Competitividad of Spain, by the project FOTOCARBON-CM S2013/MIT-2841 of the Comunidad Autónoma de Madrid, and by the COST Action CM1204. Computational time at the Centro de Computación Científica (CCC) of Universidad Autónoma de Madrid is also gratefully acknowledged.
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This paper belongs to Topical Collection P. Politzer 80th Birthday Festschrift
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Brea, O., Mó, O., Yáñez, M. et al. Are beryllium-containing biphenyl derivatives efficient anion sponges?. J Mol Model 24, 16 (2018). https://doi.org/10.1007/s00894-017-3551-1
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DOI: https://doi.org/10.1007/s00894-017-3551-1