Primary mediastinal large B cell lymphoma with coexisting aberrations of C-MYC and BCL-2: a case report and literature review

  • Yanyan Jiang
  • Wenbin Mo
  • Yuan Miao
  • Ying Liang
  • Yan Li
  • Rui ZhangEmail author
Case Report


Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive lymphoma characteristic with distinct clinical, morphologic, and immunophenotypic features. The rearrangements of C-MYC, BCL2 and/or BCL6 which are common in diffuse large B-cell lymphoma (DLBCL) are typically absent in PLMBCL. Here we proved a novel case of PMLBCL with concurrent rearrangements of C-MYC and BCL2. Histology showed typical pathomorphological features of PLMBCL. Fluorescent in situ hybridization (FISH) studies showed rearrangements of C-MYC and copy number variation (CNV) of BCL2 gene. It is not well known on the clinical significance of rearrangements of C-MYC and BCL2 genes in PMLBCL. The case gives evidence that cytogenetic testing is necessary for PMLBCLs to get precise clinical evaluation and appropriate treatment.


Primary mediastinal large B-cell lymphoma Gene rearrangement Copy number variation C-MYC BCL2 



This work was supported by the National Natural Science Foundation of China (NSFC) (Grant number: 81600117). The FISH analysis in this study was supported by this funder. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript.

Compliance with ethical standards

Conflict of interest

All authors have no conflict of interest to report.


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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2019

Authors and Affiliations

  • Yanyan Jiang
    • 1
  • Wenbin Mo
    • 1
  • Yuan Miao
    • 2
  • Ying Liang
    • 1
  • Yan Li
    • 1
  • Rui Zhang
    • 1
    Email author
  1. 1.Department of HematologyThe First Affiliated Hospital of China Medical UniversityShenyangPeople’s Republic of China
  2. 2.Department of PathologyThe First Affiliated Hospital and College of Basic Medical Sciences of China Medical UniversityShenyangPeople’s Republic of China

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