Primary mediastinal large B cell lymphoma with coexisting aberrations of C-MYC and BCL-2: a case report and literature review
Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive lymphoma characteristic with distinct clinical, morphologic, and immunophenotypic features. The rearrangements of C-MYC, BCL2 and/or BCL6 which are common in diffuse large B-cell lymphoma (DLBCL) are typically absent in PLMBCL. Here we proved a novel case of PMLBCL with concurrent rearrangements of C-MYC and BCL2. Histology showed typical pathomorphological features of PLMBCL. Fluorescent in situ hybridization (FISH) studies showed rearrangements of C-MYC and copy number variation (CNV) of BCL2 gene. It is not well known on the clinical significance of rearrangements of C-MYC and BCL2 genes in PMLBCL. The case gives evidence that cytogenetic testing is necessary for PMLBCLs to get precise clinical evaluation and appropriate treatment.
KeywordsPrimary mediastinal large B-cell lymphoma Gene rearrangement Copy number variation C-MYC BCL2
This work was supported by the National Natural Science Foundation of China (NSFC) (Grant number: 81600117). The FISH analysis in this study was supported by this funder. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript.
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Conflict of interest
All authors have no conflict of interest to report.
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