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Assessment of CD133-positive extracellular membrane vesicles in pancreatic cancer ascites and beyond

  • Christine A. Fargeas
  • Jana Karbanová
  • Denis CorbeilEmail author
Letter to the editor
  • 63 Downloads

To the Editor,

In a recent publication released online (February, 25 2019;  https://doi.org/10.1007/s00795-019-00218-5) in Medical Molecular Morphology and entitled “Glycosylation of ascites-derived exosomal CD133: a potential prognostic biomarker in patients with advanced pancreatic cancer”, Sakaue and colleagues propose that highly glycosylated CD133 may serve as a potential prognostic biomarker for pancreatic cancer. Their conclusions are partly based on the discrimination of CD133 immunoreactivities on Western blot [1]. Unfortunately, essential information emerging from earlier studies that might have driven the rationale or design of the present investigation was not provided. This includes the expression of CD133 (Prominin-1) in healthy and cancerous tissues notably pancreas and, importantly, its association with extracellular membrane vesicles (EVs). Similarly, several features regarding CD133 biology, including its role in membrane dynamics and remodeling of cellular...

Keywords

Biomarker Cancer CD133 Ectosome Exosome Prominin-1 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2019

Authors and Affiliations

  1. 1.Tissue Engineering Laboratories, Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering (CMCB)Technische Universität DresdenDresdenGermany

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