Cavin-1 is linked to lipid droplet formation in human hepatic stellate cells
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Caveolin-1 (CAV-1), discovered using immunohistocytochemistry as a major component of caveolae localized in plasma membrane caveolae, Golgi apparatus, and trans-Golgi-derived transport vesicles, is expressed either as a soluble cytoplasmic form or as a secreted form, depending on the cell type . Polymerase I and transcript release factor (PTRF)/cavin-1 selectively associate with mature caveolae at the plasma membrane but not Golgi-localized CAV. Interaction of cavin-1 with CAV-1 is not direct, but is possibly mediated through cytoskeletal interactions between microtubules and actin filaments .
Lipid droplets (LDs), which originate from the ER surface, are constantly forming, growing, and shrinking . According to the biogenesis of caveolae and LD, the process initiates by synthesis of CAV-1 in the endoplasmic reticulum (ER), followed by its exit to Golgi, where it buds as vesicles and ultimately fuses with the plasma membrane, where it can acquire additional proteins including...
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