Medical Molecular Morphology

, Volume 49, Issue 1, pp 53–56 | Cite as

CD7 aberrant expression led to a lineage switch at relapsed childhood acute pre-B lymphoblastic leukemia

  • Vahid Fallah Azad
  • Amir Abbas Hedayati Asl
  • Maryam Tashvighi
  • Naghmeh Niktoreh Mofrad
  • Mansoureh Haghighi
  • Azim Mehrvar
Case Report
First Online:
Received:
Accepted:

Abstract

Immunophenotypic changes and lineage switch between diagnosis and relapse in acute lymphoblastic leukemia are uncommon and accompanied by poor outcomes. In this report, a 12-year-old boy with diagnosis of pre-B ALL with an aberrant expression of CD 7 is described. Patient was treated with the ALL-BFM 2000 protocol and suffered an episode of relapse with a lineage switch from pre-B ALL to T cell ALL. This report concludes that presence of aberrant expression of CD7 at diagnosis of pre-B ALL can have prognostic value of lineage switch to T cell ALL at relapse.

Keywords

Lymphoblastic leukemia Lineage switch Neoplasm antigens Recurrence 
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Notes

Acknowledgments

Mahak’s research team sends their gratitude to all colleagues for their helpful discussions.

Compliance with ethical standards

Conflict of interest

The authors reported no potential conflicts of interest.

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2015

Authors and Affiliations

  • Vahid Fallah Azad
    • 1
  • Amir Abbas Hedayati Asl
    • 1
  • Maryam Tashvighi
    • 2
  • Naghmeh Niktoreh Mofrad
    • 1
  • Mansoureh Haghighi
    • 1
  • Azim Mehrvar
    • 3
  1. 1.Research DepartmentMahak’s Pediatric Cancer Treatment and Research CenterTehranIran
  2. 2.Mahak’s Pediatric Cancer Treatment and Research CenterIslamic Azad University of QomQomIran
  3. 3.Mahak’s Pediatric Cancer Treatment and Research CenterArmy Medical Science UniversityTehranIran

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