Medical Molecular Morphology

, Volume 41, Issue 4, pp 221–226 | Cite as

Immunohistochemical and electron microscopic observations of stromal cells in the human oviduct mucosa

  • Haruo Hagiwara
  • Nobuo Ohwada
  • Takeo Aoki
  • Takeshi Suzuki
  • Kuniaki Takata
Original Paper

Abstract

Stromal cells in the lamina propria of the human oviduct mucosa are unique cells that can differentiate into decidual cells during ectopic pregnancy in the oviduct. The nature of stromal cells is still unknown. In the present study, we investigated human oviductal stromal cells with transmission electron microscopy and immunohistochemistry and revealed that they had ultrastructural features similar to myofibroblasts and expressed alpha-smooth muscle actin, a marker used to identify myofibroblasts. Primary cilia were also one of the characteristic profiles of the stromal cells. These findings showed that the connective tissue-stromal cells in the human oviduct mucosa are myofibroblasts. They are considered to play an important role in the transport of oocytes by bringing about contraction of the mucosal folds.

Key words

Myofibroblast Oviduct Ultrastructure Dense body Alpha-smooth muscle actin (α-SMA) Primary cilia 

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2008

Authors and Affiliations

  • Haruo Hagiwara
    • 1
  • Nobuo Ohwada
    • 2
  • Takeo Aoki
    • 1
  • Takeshi Suzuki
    • 1
  • Kuniaki Takata
    • 1
  1. 1.Department of Anatomy and Cell BiologyGunma University Graduate School of MedicineGunmaJapan
  2. 2.Department of Maternal and Child Health Nursing and MidwiferyGunma University School of Health SciencesGunmaJapan

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