Immunohistochemical and electron microscopic observations of stromal cells in the human oviduct mucosa
Stromal cells in the lamina propria of the human oviduct mucosa are unique cells that can differentiate into decidual cells during ectopic pregnancy in the oviduct. The nature of stromal cells is still unknown. In the present study, we investigated human oviductal stromal cells with transmission electron microscopy and immunohistochemistry and revealed that they had ultrastructural features similar to myofibroblasts and expressed alpha-smooth muscle actin, a marker used to identify myofibroblasts. Primary cilia were also one of the characteristic profiles of the stromal cells. These findings showed that the connective tissue-stromal cells in the human oviduct mucosa are myofibroblasts. They are considered to play an important role in the transport of oocytes by bringing about contraction of the mucosal folds.
Key wordsMyofibroblast Oviduct Ultrastructure Dense body Alpha-smooth muscle actin (α-SMA) Primary cilia
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- 1.Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia (Basel) 27:549–550Google Scholar
- 7.Yamazaki K, Eyden BP (1996) Ultrastructural and immunohistochemical studies of stromal cells in lamina propria of human fallopian tube ampullar mucosa: the recognition of “CD34 positive reticular network” and its putative function for immune surveillance. J Submicrosc Cytol Pathol 28:325–337PubMedGoogle Scholar