Medical Molecular Morphology

, Volume 43, Issue 2, pp 82–85 | Cite as

Hybrid peripheral nerve sheath tumor of the nasal cavity showing schwannomatous, neurofibromatous, and perineuriomatous areas

  • Naoto Kuroda
  • Dmitry V. Kazakov
  • Ondrej Hes
  • Michal Michal
  • Masakazu Goda
  • Katsushi Miyazaki
  • Yoshihiro Hayashi
  • Sumika Okamoto
  • Gang-Hong Lee
Original Paper

Abstract

Soft tissue hybrid peripheral nerve sheath tumors (PNST), including schwannoma-perineurioma or neurofibroma-perineurioma, have recently been described. However, there are no reports on hybrid PNST arising in the nasopharyngeal area. In this article, we report such a case. A 58-year-old Japanese man presented with nasal obstruction and was found to have bilateral polypoid lesions in the middle meatus of the nose. Subsequently, nasal polypectomy was performed. Histologically, the tumor consisted of three components including schwannoma, neurofibroma, and perineurioma. Immunohistochemically, schwannoma, neurofibroma, and perineurioma components were positive for S-100 protein, CD34, and epithelial membrane antigen, respectively. In conclusion, this is the first case of hybrid PNST reported to occur in the nasopharyngeal area. Pathologists should be aware of the possibility that hybrid PNST may present outside soft tissue.

Key words

Hybrid peripheral nerve sheath tumor Nasal cavity 

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2010

Authors and Affiliations

  • Naoto Kuroda
    • 1
  • Dmitry V. Kazakov
    • 3
  • Ondrej Hes
    • 3
  • Michal Michal
    • 3
  • Masakazu Goda
    • 2
  • Katsushi Miyazaki
    • 2
  • Yoshihiro Hayashi
    • 4
  • Sumika Okamoto
    • 4
  • Gang-Hong Lee
    • 4
  1. 1.Department of Diagnostic PathologyKochi Red Cross HospitalKochiJapan
  2. 2.Department of OtorhinolaryngologyKochi Red Cross HospitalKochiJapan
  3. 3.Department of PathologyCharles University Hospital PlzenPlzenCzech Republic
  4. 4.Department of Pathology, Kochi Medical SchoolKochi UniversityKochiJapan

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