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Medical Molecular Morphology

, Volume 40, Issue 2, pp 55–67 | Cite as

Pathophysiological significance of adiponectin

  • Makoto Nishida
  • Tohru Funahashi
  • Iichiro Shimomura
REVIEW

Abstract

Adipose tissue, which classically has been considered as an energy-storing organ, is now viewed as a massive source of bioactive substances such as leptin, tumor necrosis factor (TNF)-α, and adiponectin. Adiponectin was discovered to be the most abundant adipose-specific transcript. Its function had been unclear, but epidemiological and clinical studies have demonstrated that serum levels of adiponectin are inversely associated with body weight, especially abdominal visceral fat accumulation. In addition, adiponectin was inversely related to cardiovascular risk factors, such as insulin resistance, blood pressure, and low-density lipoprotein (LDL) cholesterol and triglyceride levels, and was positively related to high-density lipoprotein (HDL) cholesterol levels. Moreover, low adiponectin concentration is associated with a high incidence of cardiovascular disease (CVD), diabetes, some kinds of cancer, and other various diseases. These associations suggest the clinical significance of adiponectin, and a number of investigations are now being conducted to clarify the biological functions of adiponectin. Recent studies have revealed that adiponectin exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. In addition, adiponectin has been thought to be a key molecule in “metabolic syndrome,” which is an epidemiological target for preventing cardiovascular disease. Various functions of adiponectin may possibly serve to prevent and treat obesity-related diseases and CVD. Furthermore, enhancement of adiponectin secretion or action may become a promising therapeutic target.

Key words

Adiponectin Visceral fat Adipocytokine Cardiovascular disease Metabolic syndrome 

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References

  1. 1.
    Maeda, K, Okubo, K, Shimomura, I, Funahashi, T, Matsuzawa, Y, Matsubara, K 1996cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1)Biochem Biophys Res Commun221286289PubMedGoogle Scholar
  2. 2.
    Maeda, K, Okubo, K, Shimomura, I, Mizuno, K, Matsuzawa, Y, Matsubara, K 1997Analysis of an expression profile of genes in the human adipose tissueGene (Amst)190227235Google Scholar
  3. 3.
    Funahashi, T, Nakamura, T, Shimomura, I, Maeda, K, Kuriyama, H, Takahashi, M, Arita, Y, Kihara, S, Matsuzawa, Y 1999Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesityIntern Med38202206PubMedGoogle Scholar
  4. 4.
    Nakano, Y, Tobe, T, Choi-Miura, NH, Mazda, T, Tomita, M 1996Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasmaJ Biochem (Tokyo)120803812Google Scholar
  5. 5.
    Scherer, PE, Williams, S, Fogliano, M, Baldini, G, Lodish, HF 1995A novel serum protein similar to C1q, produced exclusively in adipocytesJ Biol Chem2702674626749PubMedGoogle Scholar
  6. 6.
    Hu, E, Liang, P, Spiegelman, BM 1996AdipoQ is a novel adipose-specific gene dysregulated in obesityJ Biol Chem2711069710703PubMedGoogle Scholar
  7. 7.
    Arita, Y, Kihara, S, Ouchi, N, Takahashi, M, Maeda, K, Miyagawa, J, Hotta, K, Shimomura, I, Nakamura, T, Miyaoka, K, Kuriyama, H, Nishida, M, Yamashita, S, Okubo, K, Matsubara, K, Muraguchi, M, Ohmoto, Y, Funahashi, T, Matsuzawa, Y 1999Paradoxical decrease of an adipose-specific protein, adiponectin, in obesityBiochem Biophys Res Commun2577983PubMedGoogle Scholar
  8. 8.
    Takahashi, M, Arita, Y, Yamagata, K, Matsukawa, Y, Okutomi, K, Horie, M, Shimomura, I, Hotta, K, Kuriyama, H, Kihara, S, Nakamura, T, Yamashita, S, Funahashi, T, Matsuzawa, Y 2000Genomic structure and mutations in adipose-specific gene, adiponectinInt J Obes Relat Metab Disord24861868PubMedGoogle Scholar
  9. 9.
    Kissebah, AH, Sonnenberg, GE, Myklebust, J, Goldstein, M, Broman, K, James, RG, Marks, JA, Krakower, GR, Jacob, HJ, Weber, J, Martin, L, Blangero, J, Comuzzie, AG 2000Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndromeProc Natl Acad Sci U S A971447814483PubMedGoogle Scholar
  10. 10.
    Stumvoll, M, Tschritter, O, Fritsche, A, Staiger, H, Renn, W, Weisser, M, Machicao, F, Haring, H 2002Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetesDiabetes513741PubMedGoogle Scholar
  11. 11.
    Shapiro, L, Scherer, PE 1998The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factorCurr Biol8335338PubMedGoogle Scholar
  12. 12.
    Waki, H, Yamauchi, T, Kamon, J, Ito, Y, Uchida, S, Kita, S, Hara, K, Hada, Y, Vasseur, F, Froguel, P, Kimura, S, Nagai, R, Kadowaki, T 2003Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectinJ Biol Chem2784035240363PubMedGoogle Scholar
  13. 13.
    Pajvani, UB, Du, X, Combs, TP, Berg, AH, Rajala, MW, Schulthess, T, Engel, J, Brownlee, M, Scherer, PE 2003Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivityJ Biol Chem27890739085PubMedGoogle Scholar
  14. 14.
    Wang, Y, Lam, KS, Chan, L, Chan, KW, Lam, JB, Lam, MC, Hoo, RC, Mak, WW, Cooper, GJ, Xu, A 2006Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complexJ Biol Chem2811639116400PubMedGoogle Scholar
  15. 15.
    Fruebis, J, Tsao, TS, Javorschi, S, Ebbets-Reed, D, Erickson, MR, Yen, FT, Bihain, BE, Lodish, HF 2001Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceProc Natl Acad Sci U S A9820052010PubMedGoogle Scholar
  16. 16.
    Hotta, K, Funahashi, T, Bodkin, NL, Ortmeyer, HK, Arita, Y, Hansen, BC, Matsuzawa, Y 2001Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeysDiabetes5011261133PubMedGoogle Scholar
  17. 17.
    Yokota, T, Meka, CS, Medina, KL, Igarashi, H, Comp, PC, Takahashi, M, Nishida, M, Oritani, K, Miyagawa, J, Funahashi, T, Tomiyama, Y, Matsuzawa, Y, Kincade, PW 2002Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandinsJ Clin Invest10913031310PubMedGoogle Scholar
  18. 18.
    Berner, HS, Lyngstadaas, SP, Spahr, A, Monjo, M, Thommesen, L, Drevon, CA, Syversen, U, Reseland, JE 2004Adiponectin and its receptors are expressed in bone-forming cellsBone (NY)35842849Google Scholar
  19. 19.
    Corbetta, S, Bulfamante, G, Cortelazzi, D, Barresi, V, Cetin, I, Mantovani, G, Bondioni, S, Beck-Peccoz, P, Spada, A 2005Adiponectin expression in human fetal tissues during mid- and late gestationJ Clin Endocrinol Metab9023972402PubMedGoogle Scholar
  20. 20.
    Pineiro, R, Iglesias, MJ, Gallego, R, Raghay, K, Eiras, S, Rubio, J, Dieguez, C, Gualillo, O, Gonzalez-Juanatey, JR, Lago, F 2005Adiponectin is synthesized and secreted by human and murine cardiomyocytesFEBS Lett57951635169PubMedGoogle Scholar
  21. 21.
    Katsiougiannis, S, Kapsogeorgou, EK, Manoussakis, MN, Skopouli, FN 2006Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectinArthritis Rheum5422952299PubMedGoogle Scholar
  22. 22.
    Fujimoto, N, Matsuo, N, Sumiyoshi, H, Yamaguchi, K, Saikawa, T, Yoshimatsu, H, Yoshioka, H 2005Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryosBiochim Biophys Acta1731112PubMedGoogle Scholar
  23. 23.
    Bogan, JS, Lodish, HF 1999Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4J Cell Biol146609620PubMedGoogle Scholar
  24. 24.
    Xie, L, Boyle, D, Sanford, D, Scherer, PE, Pessin, JE, Mora, S 2006Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesiclesJ Biol Chem28172537259PubMedGoogle Scholar
  25. 25.
    Clarke, M, Ewart, MA, Santy, LC, Prekeris, R, Gould, GW 2006ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathwayBiochem Biophys Res Commun34213611367PubMedGoogle Scholar
  26. 26.
    Feng, L, Arvan, P 2003The trafficking of alpha 1-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cellsJ Biol Chem2783148631494PubMedGoogle Scholar
  27. 27.
    Turner, MD, Arvan, P 2000Protein traffic from the secretory pathway to the endosomal system in pancreatic beta cellsJ Biol Chem2751402514030PubMedGoogle Scholar
  28. 28.
    Millar, CA, Meerloo, T, Martin, S, Hickson, GR, Shimwell, NJ, Wakelam, MJ, James, DE, Gould, GW 2000Adipsin and the glucose transporter GLUT4 traffic to the cell surface via independent pathways in adipocytesTraffic1141151PubMedGoogle Scholar
  29. 29.
    Fischer von Mollard, G, Stahl, B, Khokhlatchev, A, Sudhof, TC, Jahn, R 1994Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosisJ Biol Chem2691097110974PubMedGoogle Scholar
  30. 30.
    Zerial, M, McBride, H 2001Rab proteins as membrane organizersNat Rev Mol Cell Biol2107117PubMedGoogle Scholar
  31. 31.
    Donaldson, JG, Jackson, CL 2000Regulators and effectors of the ARF GTPasesCurr Opin Cell Biol12475482PubMedGoogle Scholar
  32. 32.
    Kessler, A, Tomas, E, Immler, D, Meyer, HE, Zorzano, A, Eckel, J 2000Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulinDiabetologia4315181527PubMedGoogle Scholar
  33. 33.
    Aikawa, Y, Martin, TF 2003ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosisJ Cell Biol162647659PubMedGoogle Scholar
  34. 34.
    Brown, FD, Rozelle, AL, Yin, HL, Balla, T, Donaldson, JG 2001Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane trafficJ Cell Biol15410071017PubMedGoogle Scholar
  35. 35.
    D'Souza-Schorey, C, Li, G, Colombo, MI, Stahl, PD 1995A regulatory role for ARF6 in receptor-mediated endocytosisScience26711751178PubMedGoogle Scholar
  36. 36.
    Bose, A, Guilherme, A, Huang, S, Hubbard, AC, Lane, CR, Soriano, NA, Czech, MP 2005The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytesJ Biol Chem2803694636951PubMedGoogle Scholar
  37. 37.
    Novikoff, AB, Novikoff, PM, Rosen, OM, Rubin, CS 1980Organelle relationships in cultured 3T3-L1 preadipocytesJ Cell Biol87180196PubMedGoogle Scholar
  38. 38.
    Yamauchi, T, Kamon, J, Ito, Y, Tsuchida, A, Yokomizo, T, Kita, S, Sugiyama, T, Miyagishi, M, Hara, K, Tsunoda, M, Murakami, K, Ohteki, T, Uchida, S, Takekawa, S, Waki, H, Tsuno, NH, Shibata, Y, Terauchi, Y, Froguel, P, Tobe, K, Koyasu, S, Taira, K, Kitamura, T, Shimizu, T, Nagai, R, Kadowaki, T 2003Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature (Lond)423762769Google Scholar
  39. 39.
    Kos, K, Harte, AL, da Silva, NF, Tontchev, A, Chalakov, G, James, S, Snead, DR, Hoggart, B, O'hare, JP, McTernan, PG, Kumar, S 2007Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamusJ Clin Endocrinol Metab9211291136PubMedGoogle Scholar
  40. 40.
    Hug, C, Wang, J, Ahmad, NS, Bogan, JS, Tsao, TS, Lodish, HF 2004T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectinProc Natl Acad Sci U S A1011030810313PubMedGoogle Scholar
  41. 41.
    Huang, ZY, Wu, Y, Hedrick, N, Gutmann, DH 2003T-cadherin mediated cell growth regulation involves G2 phase arrest and requires p21 (CIP1/WAF1) expressionMol Cell Biol23566578PubMedGoogle Scholar
  42. 42.
    Takeuchi, T, Misaki, A, Liang, S-B, Tachibana, A, Hayashi, N, Sonobe, H, Ohtsuki, Y 2000Expression of T-cadherin (CDH13, H-cadherin) in human brain and its characteristics as a negative growth regulator of EGF in neuroblastoma cellsJ Neurochem7414891497PubMedGoogle Scholar
  43. 43.
    Berg, AH, Combs, TP, Du, X, Brownlee, M, Scherer, PE 2001The adipocyte-secreted protein Acrp30 enhances hepatic insulin actionNat Med7947953PubMedGoogle Scholar
  44. 44.
    Yang, WS, Lee, WJ, Funahashi, T, Tanaka, S, Matsuzawa, Y, Chao, CL, Chen, CL, Tai, TY, Chuang, LM 2001Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectinJ Clin Endocrinol Metab8638153819PubMedGoogle Scholar
  45. 45.
    Takahashi, M, Funahashi, T, Shimomura, I, Miyaoka, Y, Matsuzawa, Y 1996Plasma leptin levels and body fat distributionHorm Metab Res28751752PubMedGoogle Scholar
  46. 46.
    Cnop, M, Havel, PJ, Utzschneider, KM, Carr, DB, Sinha, MK, Boyko, EJ, Retzlaff, BM, Knopp, RH, Brunzell, JD, Kahn, SE 2003Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sexDiabetologia46459469PubMedGoogle Scholar
  47. 47.
    Yatagai, T, Nagasaka, S, Taniguchi, A, Fukushima, M, Nakamura, T, Kuroe, A, Nakai, Y, Ishibashi, S 2003Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitusMetabolism5212741278PubMedGoogle Scholar
  48. 48.
    Maeda, N, Takahashi, M, Funahashi, T, Kihara, S, Nishizawa, H, Kishida, K, Nagaretani, H, Matsuda, M, Komuro, R, Ouchi, N, Kuriyama, H, Hotta, K, Nakamura, T, Shimomura, I, Matsuzawa, Y 2001PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinDiabetes5020942099PubMedGoogle Scholar
  49. 49.
    Kumada, M, Kihara, S, Sumitsuji, S, Kawamoto, T, Matsumoto, S, Ouchi, N, Arita, Y, Okamoto, Y, Shimomura, I, Hiraoka, H, Nakamura, T, Matsuzawa, Y 2003Association of hypoadiponectinemia with coronary artery disease in menArterioscler Thromb Vasc Biol238589PubMedGoogle Scholar
  50. 50.
    Zoccali, C, Mallamaci, F, Tripepi, G, Benedetto, FAQ, Cutrupi, S, Parlongo, S, Malatino, LS, Monanno, G, Seminara, G, Rapisarda, F, Fatuzzo, P, Buemi, M, Nicocia, G, Tanaka, S, Kihara, S, Funahashi, T, Matsuzawa, Y 2002Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal diseaseJ Am Soc Nephrol13134141PubMedGoogle Scholar
  51. 51.
    Pischon, T, Girman, CJ, Hotamisligil, GS, Rifai, N, Hu, FB, Rimm, EB 2004Plasma adiponectin levels and risk of myocardial infarction in menJAMA29117301737PubMedGoogle Scholar
  52. 52.
    Hotta, K, Funahashi, T, Arita, Y, Takahashi, M, Matsuda, M, Okamoto, Y, Iwahashi, H, Kuriyama, H, Ouchi, N, Maeda, K, Nishida, M, Kihara, S, Sakai, N, Nakajima, T, Hasegawa, K, Muraguchi, M, Ohmoto, Y, Nakamura, T, Yamashita, S, Hanafusa, T, Matsuzawa, Y 2000Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patientsArterioscler Thromb Vasc Biol2015951599PubMedGoogle Scholar
  53. 53.
    Kojima, S, Funahashi, T, Maruyoshi, H, Honda, O, Sugiyama, S, Kawano, H, Soejima, H, Miyamoto, S, Hokamaki, J, Sakamoto, T, Yoshimura, M, Kitagawa, A, Matsuzawa, Y, Ogawa, H 2005Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheromaThromb Res115483490PubMedGoogle Scholar
  54. 54.
    Ouchi, N, Kihara, S, Arita, Y, Maeda, K, Kuriyama, H, Okamoto, Y, Hotta, K, Nishida, M, Takahashi, M, Nakamura, T, Yamashita, S, Funahashi, T, Matsuzawa, Y 1999Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectinCirculation10024732476PubMedGoogle Scholar
  55. 55.
    Nakamura, Y, Shimada, K, Fukuda, D, Shimada, Y, Ehara, S, Hirose, M, Kataoka, T, Kamimori, K, Shimodozono, S, Kobayashi, Y, Yoshiyama, M, Takeuchi, K, Yoshikawa, J 2004Implications of plasma concentrations of adiponectin in patients with coronary artery diseaseHeart90528533PubMedGoogle Scholar
  56. 56.
    Otsuka, F, Sugiyama, S, Kojima, S, Maruyoshi, H, Funahashi, T, Matsui, K, Sakamoto, T, Yoshimura, M, Kimura, K, Umemura, S, Ogawa, H 2006Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery diseaseJ Am Coll Cardiol4811551162PubMedGoogle Scholar
  57. 57.
    Lindsay, RS, Funahashi, T, Hanson, RL, Matsuzawa, Y, Tanaka, S, Tataranni, PA, Knowler, WC, Krakoff, J 2002Adiponectin and development of type 2 diabetes in the Pima Indian populationLancet3605758PubMedGoogle Scholar
  58. 58.
    Daimon, M Oizumi, T Saitoh, T Kameda, W Hirata, A Yamaguchi, H Ohnuma, H Igarashi, M Tominaga, M Kato, T Funagata Study2003Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: the Funagata studyDiabetes Care2620152020PubMedGoogle Scholar
  59. 59.
    Yamamoto, Y, Hirose, H, Saito, I, Nishikai, K, Saruta, T 2004Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two year follow-up study in Japanese populationJ Clin Endocrinol Metab898790PubMedGoogle Scholar
  60. 60.
    Snehalatha, C, Mukesh, B, Simon, M, Viswanathan, V, Haffner, SM, Ramachandran, A 2003Plasma adiponectin is an independent predictor of type 2 diabetes in Asian IndiansDiabetes Care2632263229PubMedGoogle Scholar
  61. 61.
    Stefan, N, Vozarova, B, Funahashi, T, Matsuzawa, Y, Weyer, C, Lindsay, RS, Youngren, JF, Havel, PJ, Pratley, RE, Bogardus, C, Tataranni, PA 2002Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration and low plasma concentration precedes a decrease in whole body insulin sensitivity in humansDiabetes5118841888PubMedGoogle Scholar
  62. 62.
    Snijder, MB, Heine, RJ, Seidell, JC, Bouter, LM, Stehouwer, CD, Nijpels, G, Funahashi, T, Matsuzawa, Y, Shimomura, I, Dekker, JM 2006Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the Hoorn studyDiabetes Care2924982503PubMedGoogle Scholar
  63. 63.
    Adamczak, M, Wiecek, A, Funahashi, T, Chudek, J, Kokot, F, Matsuzawa, Y 2003Decreased plasma adiponectin concentration in patients with essential hypertensionAm J Hypertens167275PubMedGoogle Scholar
  64. 64.
    Iwashima, Y, Katsuya, T, Ishikawa, K, Ouchi, N, Ohishi, M, Sugimoto, K, Fu, Y, Motone, M, Yamamoto, K, Matsuo, A, Ohashi, K, Kihara, S, Funahashi, T, Rakugi, H, Matsuzawa, Y, Ogihara, T 2004Hypoadiponectinemia is an independent risk factor for hypertensionHypertension4313181323PubMedGoogle Scholar
  65. 65.
    Mallamaci, F, Zoccali, C, Cuzzola, F, Tripepi, G, Cutrupi, S, Parlongo, S, Tanaka, S, Ouchi, N, Kihara, S, Funahashi, T, Matsuzawa, Y 2002Adiponectin and essential hypertensionJ Nephrol15507511PubMedGoogle Scholar
  66. 66.
    Ohashi, K, Kihara, S, Ouchi, N, Kumada, M, Fujita, K, Hiuge, A, Hibuse, T, Ryo, M, Nishizawa, H, Maeda, N, Maeda, K, Shibata, R, Walsh, K, Funahashi, T, Shimomura, I 2006Adiponectin replenishment ameliorates obesity-related hypertensionHypertension4711081116PubMedGoogle Scholar
  67. 67.
    Matsubara, M, Maruoka, S, Katayose, S 2002Decreased plasma adiponectin concentrations in women with dyslipidemiaJ Clin Endocrinol Metab8727642769PubMedGoogle Scholar
  68. 68.
    Kazumi, T, Kawaguchi, A, Sakai, K, Hirano, T, Yoshino, G 2002Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressureDiabetes Care25971976PubMedGoogle Scholar
  69. 69.
    Hulthe, J, Hulten, LM, Fagerberg, B 2003Low adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: atherosclerosis and insulin resistance studyMetabolism5216121614PubMedGoogle Scholar
  70. 70.
    Zietz, B, Herfarth, H, Paul, G, Ehling, A, Muller-Ladner, U, Scholmerich, J, Schaffler, A 2003Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetesFEBS Lett545103104PubMedGoogle Scholar
  71. 71.
    Schulze, MB, Rimm, EB, Shai, I, Rifai, N, Hu, FB 2004Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetesDiabetes Care2716801687PubMedGoogle Scholar
  72. 72.
    Neumeier, M, Sigruener, A, Eggenhofer, E, Weigert, J, Weiss, TS, Schaeffler, A, Schlitt, HJ, Aslanidis, C, Piso, P, Langmann, T, Schmitz, G, Scholmerich, J, Buechler, C 2007High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytesBiochem Biophys Res Commun352543548PubMedGoogle Scholar
  73. 73.
    Choi, KM, Lee, J, Lee, KW, Seo, JA, Oh, JH, Kim, SG, Kim, NH, Choi, DS, Baik, SH 2004Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly KoreansClin Endocrinol (Oxf)617580Google Scholar
  74. 74.
    Ryo, M, Nakamura, T, Kihara, S, Kumada, M, Shibazaki, S, Takahashi, M, Nagai, M, Matsuzawa, Y, Funahashi, T 2004Adiponectin as a biomarker of the metabolic syndromeCirc J68975981PubMedGoogle Scholar
  75. 75.
    Ohashi, K, Ouchi, N, Kihara, S, Funahashi, T, Nakamura, T, Sumitsuji, S, Kawamoto, T, Matsumoto, S, Nagaretani, H, Kumada, M, Okamoto, Y, Nishizawa, H, Kishida, K, Maeda, N, Hiraoka, H, Iwashima, Y, Ishikawa, K, Ohishi, M, Katsuya, T, Rakugi, H, Ogihara, T, Matsuzawa, Y 2004Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery diseaseJ Am Coll Cardiol4311951200PubMedGoogle Scholar
  76. 76.
    Engeli, S, Feldpausch, M, Gorzelniak, K, Hartwig, F, Heintze, U, Janke, J, Mohlig, M, Pfeiffer, AF, Luft, FC, Sharma, AM 2003Association between adiponectin and mediators of inflammation in obese womenDiabetes52942947PubMedGoogle Scholar
  77. 77.
    Ouchi, N, Kihara, S, Funahashi, T, Nakamura, T, Nishida, M, Kumada, M, Okamoto, Y, Ohashi, K, Nagaretani, H, Kishida, K, Nishizawa, H, Maeda, N, Kobayashi, H, Hiraoka, H, Matsuzawa, Y 2003Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissueCirculation107671674PubMedGoogle Scholar
  78. 78.
    Krakoff, J, Funahashi, T, Stehouwer, CD, Schalkwijk, CG, Tanaka, S, Matsuzawa, Y, Kobes, S, Tataranni, PA, Hanson, RL, Knowler, WC, Lindsay, RS 2003Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima IndianDiabetes Care2617451751PubMedGoogle Scholar
  79. 79.
    Matsubara, M, Namioka, K, Katayose, S 2003Decreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevationEur J Endocrinol148657662PubMedGoogle Scholar
  80. 80.
    Kern, PA, Di Gregorio, GB, Lu, T, Rassouli, N, Ranganathan, G 2003Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expressionDiabetes5217791785PubMedGoogle Scholar
  81. 81.
    Yamamoto, K, Kiyohara, T, Murayama, Y, Kihara, S, Okamoto, Y, Funahashi, T, Ito, T, Nezu, R, Tsutsui, S, Miyagawa, JI, Tamura, S, Matsuzawa, Y, Shimomura, I, Shinomura, Y 2005Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's diseaseGut54789796PubMedGoogle Scholar
  82. 82.
    Senolt, L, Pavelka, K, Housa, D, Haluzik, M 2006Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritisCytokine35247252PubMedGoogle Scholar
  83. 83.
    Kelesidis, I, Kelesidis, T, Mantzoros, CS 2006Adiponectin and cancer: a systematic reviewBr J Cancer9412211225PubMedGoogle Scholar
  84. 84.
    Housa, D, Housova, J, Vernerova, Z, Haluzik, M 2005Adipocytokines and cancerPhysiol Res55233244PubMedGoogle Scholar
  85. 85.
    Petridou, E, Mantzoros, C, Dessypris, N, Koukoulomatis, P, Addy, C, Voulgaris, Z, Chrousos, G, Trichopoulos, D 2003Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in GreeceJ Clin Endocrinol Metab88993997PubMedGoogle Scholar
  86. 86.
    Dal Maso, L, Augustin, LS, Karalis, A, Talamini, R, Franceschi, S, Trichopoulos, D, Mantzoros, CS, La Vecchia, C 2004Circulating adiponectin and endometrial cancer riskJ Clin Endocrinol Metab8911601163PubMedGoogle Scholar
  87. 87.
    Cust, AE, Kaaks, R, Friedenreich, C, Bonnet, F, Laville, M, Lukanova, A, Rinaldi, S, Dossus, L, Slimani, N, Lundin, E, Tjonneland, A, Olsen, A, Overvad, K, Clavel-Chapelon, F, Mesrine, S, Joulin, V, Linseisen, J, Rohrmann, S, Pischon, T, Boeing, H, Trichopoulos, D, Trichopoulou, A, Benetou, V, Palli, D, Berrino, F, Tumino, R, Sacerdote, C, Mattiello, A, Quiros, JR, Mendez, MA, Sanchez, MJ, Larranaga, N, Tormo, MJ, Ardanaz, E, Bueno-de-Mesquita, HB, Peeters, PH, van Gils, CH, Khaw, KT, Bingham, S, Allen, N, Key, T, Jenab, M, Riboli, E 2007Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal womenJ Clin Endocrinol Metab92255263PubMedGoogle Scholar
  88. 88.
    Mantzoros, C, Petridou, E, Dessypris, N, Chavelas, C, Dalamaga, M, Alexe, DM, Papadiamantis, Y, Markopoulos, C, Spanos, E, Chrousos, G, Trichopoulos, D 2004Adiponectin and breast cancer riskJ Clin Endocrinol Metab8911021107PubMedGoogle Scholar
  89. 89.
    Tworoger, SS, Eliassen, AH, Kelesidis, T, Colditz, GA, Willett, WC, Mantzoros, C, Hankinson, SE 2007Plasma adiponectin concentrations and risk of incident breast cancerJ Clin Endocrinol Metab9215101516PubMedGoogle Scholar
  90. 90.
    Wei, E, Giovannucci, E, Fuchs, C, Wilett, W, Mantzoros, CS 2005Plasma adiponectin levels and the risk of colorectal cancer in menJNCI9716881694PubMedGoogle Scholar
  91. 91.
    Otake, S, Takeda, H, Suzuki, Y, Fukui, T, Watanabe, S, Ishihama, K, Saito, T, Togashi, H, Nakamura, T, Matsuzawa, Y, Kawata, S 2005Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistanceClin Cancer Res1136423646PubMedGoogle Scholar
  92. 92.
    Ishikawa, M, Kitayama, J, Kazama, S, Hiramatsu, T, Hatano, K, Nagawa, H 2005Plasma adiponectin and gastric cancerClin Cancer Res11466472PubMedGoogle Scholar
  93. 93.
    Goktas, S, Yilmaz, MI, Caglar, K, Sonmez, A, Kilic, S, Bedir, S 2005Prostate cancer and adiponectinUrology6511681172PubMedGoogle Scholar
  94. 94.
    Petridou, E, Mantzoros, CS, Dessypris, N, Dikalioti, SK, Trichopoulos, D 2006Adiponectin in relation to childhood myeloblastic leukaemiaBr J Cancer94156160PubMedGoogle Scholar
  95. 95.
    Brakenhielm, E, Veitonmaki, N, Cao, R, Kihara, S, Matsuzawa, Y, Zhivotovsky, B, Funahashi, T, Cao, Y 2004Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosisProc Natl Acad Sci U S A1024762481Google Scholar
  96. 96.
    Richards, JB, Valdes, AM, Burling, K, Perks, UC, Spector, TD 2007Serum adiponectin and bone mineral density in womenJ Clin Endocrinol Metab9215171523PubMedGoogle Scholar
  97. 97.
    Okamoto, Y, Arita, Y, Nishida, M, Muraguchi, M, Ouchi, N, Takahashi, M, Igura, T, Inui, Y, Kihara, S, Nakamura, T, Yamashita, S, Miyagawa, J, Funahashi, T, Matsuzawa, Y 2000An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular wallsHorm Metab Res324750PubMedGoogle Scholar
  98. 98.
    Shimabukuro, M, Higa, N, Asahi, T, Oshiro, Y, Takasu, N, Tagawa, T, Ueda, S, Shimomura, I, Funahashi, T, Matsuzawa, Y 2003Hypoadiponectinemia is closely linked to endothelial dysfunction in manJ Clin Endocrinol Metab8832363240PubMedGoogle Scholar
  99. 99.
    Tan, KC, Xu, A, Chow, WS, Lam, MC, Ai, VH, Tam, SC, Lam, KS 2004Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilationJ Clin Endocrinol Metab89765769PubMedGoogle Scholar
  100. 100.
    Chen, H, Montagnani, M, Funahashi, T, Shimomura, I, Quon, MJ 2003Adiponectin stimulates production of nitric oxide in vascular endothelial cellsJ Biol Chem2784502145026PubMedGoogle Scholar
  101. 101.
    Motoshima, H, Wu, X, Mahadev, K, Goldstein, BJ 2004Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDLBiochem Biophys Res Commun315264271PubMedGoogle Scholar
  102. 102.
    Ouchi, N, Ohishi, M, Kihara, S, Funahashi, T, Nakamura, T, Nagaretani, H, Kumada, M, Ohashi, K, Okamoto, Y, Nishizawa, H, Kishida, K, Maeda, N, Nagasawa, A, Kobayashi, H, Hiraoka, H, Komai, N, Kaibe, M, Rakugi, H, Ogihara, T, Matsuzawa, Y 2003Association of hypoadiponectinemia with impaired vasoreactivityHypertension42231234PubMedGoogle Scholar
  103. 103.
    Ouchi, N, Kihara, S, Arita, Y, Nishida, M, Matsuyama, A, Okamoto, Y, Ishigami, M, Kuriyama, H, Kishida, K, Nishizawa, H, Hotta, K, Muraguchi, M, Ohmoto, Y, Yamashita, S, Funahashi, T, Matsuzawa, Y 2001Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophagesCirculation10310571063PubMedGoogle Scholar
  104. 104.
    Kumada, M, Kihara, S, Ouchi, N, Kobayashi, H, Okamoto, Y, Ohashi, K, Maeda, K, Nagaretani, H, Kishida, K, Maeda, N, Nagasawa, A, Funahashi, T, Matsuzawa, Y 2004Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophagesCirculation10920462049PubMedGoogle Scholar
  105. 105.
    Arita, Y, Kihara, S, Ouchi, N, Maeda, K, Kuriyama, H, Okamoto, Y, Kumada, M, Hotta, K, Nishida, M, Takahashi, M, Nakamura, T, Shimomura, I, Muraguchi, M, Ohmoto, Y, Funahashi, T, Matsuzawa, Y 2002Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cellCirculation10528932898PubMedGoogle Scholar
  106. 106.
    Matsuzawa, Y, Funahashi, T, Kihara, S, Shimomura, I 2004Adiponectin and metabolic syndromeArterioscler Thromb Vasc Biol242933PubMedGoogle Scholar
  107. 107.
    Kato, H, Kashiwagi, H, Shiraga, M, Tadokoro, S, Kamae, T, Ujiie, H, Honda, S, Miyata, S, Ijiri, Y, Yamamoto, J, Maeda, N, Funahashi, T, Kurata, Y, Shimomura, I, Tomiyama, Y, Kanakura, Y 2006Adiponectin acts as an endogenous antithrombotic factorArterioscler Thromb Vasc Biol26224230PubMedGoogle Scholar
  108. 108.
    Shibata, R, Sato, K, Pimentel, DR, Takemura, Y, Kihara, S, Ohashi, K, Funahashi, T, Ouchi, N, Walsh, K 2005Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsNat Med1110961103PubMedGoogle Scholar
  109. 109.
    Shibata, R, Ouchi, N, Ito, M, Kihara, S, Shiojima, I, Pimentel, DR, Kumada, M, Sato, K, Schiekofer, S, Ohashi, K, Funahashi, T, Colucci, WS, Walsh, K 2004Adiponectin-mediated modulation of hypertrophic signals in the heartNat Med1013841389PubMedGoogle Scholar
  110. 110.
    Combs, TP, Berg, AH, Obici, S, Scherer, PE, Rossetti, L 2001Endogenous glucose production is inhibited by the adipose-derived protein Acrp30J Clin Invest10818751881PubMedGoogle Scholar
  111. 111.
    Yamauchi, T, Kamon, J, Minokoshi, Y, Ito, Y, Waki, H, Uchida, S, Yamashita, S, Noda, M, Kita, S, Ueki, K, Eto, K, Akanuma, Y, Froguel, P, Foufelle, F, Ferre, P, Carling, D, Kimura, S, Nagai, R, Kahn, BB, Kadowaki, T 2002Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseNat Med812881295PubMedGoogle Scholar
  112. 112.
    Stefan, N, Stumvoll, M, Vozarova, B, Weyer, C, Funahashi, T, Matsuzawa, Y, Bogardus, C, Tataranni, PA 2003Plasma adiponectin and endogenous glucose production in humansDiabetes Care2633153319PubMedGoogle Scholar
  113. 113.
    Fruebis, J, Tsao, TS, Javorschi, S, Ebbets-Reed, D, Erickson, MR, Yen, FT, Bihain, BE, Lodish, HF 2001Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceProc Natl Acad Sci U S A9820052010PubMedGoogle Scholar
  114. 114.
    Yamauchi, T, Kamon, J, Waki, H, Terauchi, Y, Kubota, N, Hara, K, Mori, Y, Ide, T, Murakami, K, Tsuboyama-Kasaoka, N, Ezaki, O, Akanuma, Y, Gavrilova, O, Vinson, C, Reitman, ML, Kagechika, H, Shudo, K, Yoda, M, Nakano, Y, Tobe, K, Nagai, R, Kimura, S, Tomita, M, Froguel, P, Kadowaki, T 2001The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityNat Med7941946PubMedGoogle Scholar
  115. 115.
    Tomas, E, Tsao, TS, Saha, AK, Murrey, HE, Zhang, CC, Itani, SI, Lodish, HF, Ruderman, NB 2002Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activationProc Natl Acad Sci U S A991630916313PubMedGoogle Scholar
  116. 116.
    Maeda, N, Shimomura, I, Kishida, K, Nishizawa, H, Matsuda, M, Nagaretani, H, Furuyama, N, Kondo, H, Takahashi, M, Arita, Y, Komuro, R, Ouchi, N, Kihara, S, Tochino, Y, Okutomi, K, Horie, M, Takeda, S, Aoyama, T, Funahashi, T, Matsuzawa, Y 2002Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Nat Med8731737PubMedGoogle Scholar
  117. 117.
    Yamauchi, T, Nio, Y, Maki, T, Kobayashi, M, Takazawa, T, Iwabu, M, Okada-Iwabu, M, Kawamoto, S, Kubota, N, Kubota, T, Ito, Y, Kamon, J, Tsuchida, A, Kumagai, K, Kozono, H, Hada, Y, Ogata, H, Tokuyama, K, Tsunoda, M, Ide, T, Murakami, K, Awazawa, M, Takamoto, I, Froguel, P, Hara, K, Tobe, K, Nagai, R, Ueki, K, Kadowaki, T 2007Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actionsNat Med13332339PubMedGoogle Scholar
  118. 118.
    Wang, C, Mao, X, Wang, L, Liu, M, Wetzel, MD, Guan, KL, Dong, LQ, Liu, F 2007Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1J Biol Chem28279917996PubMedGoogle Scholar
  119. 119.
    Okamoto, Y, Kihara, S, Ouchi, N, Nishida, M, Arita, Y, Kumada, M, Ohashi, K, Sakai, N, Shimomura, I, Kobayashi, H, Terasaka, N, Inaba, T, Funahashi, T, Matsuzawa, Y 2002Adiponectin reduces atherosclerosis in apolipoprotein E-deficient miceCirculation10627672770PubMedGoogle Scholar
  120. 120.
    Ouchi, N, Kihara, S, Arita, Y, Okamoto, Y, Maeda, K, Kuriyama, H, Hotta, K, Nishida, M, Takahashi, M, Muraguchi, M, Ohmoto, Y, Nakamura, T, Yamashita, S, Funahashi, T, Matsuzawa, Y 2000Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathwayCirculation10212961301PubMedGoogle Scholar
  121. 121.
    Takemura, Y, Ouchi, N, Shibata, R, Aprahamian, T, Kirber, MT, Summer, RS, Kihara, S, Walsh, K 2007Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodiesJ Clin Invest117375386PubMedGoogle Scholar
  122. 122.
    Vandivier, RW, Ogden, CA, Fadok, VA, Hoffmann, PR, Brown, KK, Botto, M, Walport, MJ, Fisher, JH 2002Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complexJ Immunol16939783986PubMedGoogle Scholar
  123. 123.
    Tsao, TS, Murrey, HE, Hug, C, Lee, DH, Lodish, HF 2002Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30)J Biol Chem2772935929362PubMedGoogle Scholar
  124. 124.
    Nishihara, T, Matsuda, M, Araki, H, Oshima, K, Kihara, S, Funahashi, T, Shimomura, I 2006Effect of adiponectin on murine colitis induced by dextran sulfate sodiumGastroenterology131853861PubMedGoogle Scholar
  125. 125.
    Kamada, Y, Tamura, S, Kiso, S, Matsumoto, H, Saji, Y, Yoshida, Y, Fukui, K, Maeda, N, Nishizawa, H, Nagaretani, H, Okamoto, Y, Kihara, S, Miyagawa, J, Shinomura, Y, Funahashi, T, Matsuzawa, Y 2003Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectinGastroenterology12517961807PubMedGoogle Scholar
  126. 126.
    Matsumoto, H, Tamura, S, Kamada, Y, Kiso, S, Fukushima, J, Wada, A, Maeda, N, Kihara, S, Funahashi, T, Matsuzawa, Y, Shimomura, I, Hayashi, N 2006Adiponectin deficiency exacerbates lipopolysaccharide/-galactosamine-induced liver injury in miceWorld J Gastroenterol1233523358PubMedGoogle Scholar
  127. 127.
    Shore, SA, Terry, RD, Flynt, L, Xu, A, Hug, C 2006Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in miceJ Allergy Clin Immunol118389395PubMedGoogle Scholar
  128. 128.
    Peake, PW, Shen, Y, Campbell, LV, Charlesworth, JA 2006Human adiponectin binds to bacterial lipopolysaccharideBiochem Biophys Res Commun341108115PubMedGoogle Scholar
  129. 129.
    Kubota, N, Terauchi, Y, Yamauchi, T, Kubota, T, Moroi, M, Matsui, J, Eto, K, Yamashita, T, Kamon, J, Satoh, H, Yano, W, Froguel, P, Nagai, R, Kimura, S, Kadowaki, T, Noda, T 2002Disruption of adiponectin causes insulin resistance and neointimal formationJ Biol Chem2772586325866PubMedGoogle Scholar
  130. 130.
    Matsuda, M, Shimomura, I, Sata, M, Arita, Y, Nishida, M, Maeda, N, Kumada, M, Okamoto, Y, Nagaretani, H, Nishizawa, H, Kishida, K, Komuro, R, Ouchi, N, Kihara, S, Nagai, R, Funahashi, T, Matsuzawa, Y 2002Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axisJ Biol Chem2773748737491PubMedGoogle Scholar
  131. 131.
    Yu, JG, Javorschi, S, Hevener, AL, Kruszynska, YT, Norman, RA, Sinha, M, Olefsky, JM 2002The effect of thiazolidinedione on plasma adiponectin levels in normal, obese, and type 2 diabetic subjectsDiabetes5129682974PubMedGoogle Scholar
  132. 132.
    Yang, WS, Jeng, CY, Wu, TJ, Tanaka, S, Funahashi, T, Matsuzawa, Y, Wang, JP, Chen, CL, Tai, TY, Chuang, LM 2002Synthetic peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patientsDiabetes Care25376380PubMedGoogle Scholar
  133. 133.
    Tonelli, J, Li, W, Kishore, P, Pajvani, UB, Kwon, E, Weaver, C, Scherer, PE, Hawkins, M 2004Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetesDiabetes5316211629PubMedGoogle Scholar
  134. 134.
    Bodles, AM, Banga, A, Rasouli, N, Ono, F, Kern, PA, Owens, RJ 2006Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytesAm J Physiol Endocrinol Metab291E1100E1105PubMedGoogle Scholar
  135. 135.
    Hiuge, A, Tenenbaum, A, Maeda, N, Benderly, M, Kumada, M, Fisman, EZ, Tanne, D, Matas, Z, Hibuse, T, Fujita, K, Nishizawa, H, Adler, Y, Motro, M, Kihara, S, Shimomura, I, Behar, S, Funahashi, T 2006Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin levelArterioscler Thromb Vasc Biol27635641PubMedGoogle Scholar
  136. 136.
    Chinetti, G, Zawadski, C, Fruchart, JC, Staels, B 2004Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXRBiochem Biophys Res Commun314151158PubMedGoogle Scholar
  137. 137.
    Iwaki, M, Matsuda, M, Maeda, N, Funahashi, T, Matsuzawa, Y, Makishima, M, Shimomura, I 2003Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptorsDiabetes5216551663PubMedGoogle Scholar

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Makoto Nishida
    • 1
  • Tohru Funahashi
    • 2
  • Iichiro Shimomura
    • 2
  1. 1.Health Care CenterOsaka University 1-17 MachikaneyamaOsakaJapan
  2. 2.Department of Metabolic Medicine, Graduate School of MedicineOsaka UniversityOsakaJapan

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