Medical Molecular Morphology

, Volume 40, Issue 2, pp 95–102 | Cite as

P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders

  • Hiroaki Soma
  • Hiroyuki Osawa
  • Tatsuo Oguro
  • Isao Yoshihama
  • Koji Fujita
  • Shoichiro Mineo
  • Motoshige Kudo
  • Kayoko Tanaka
  • Masumi Akita
  • Satoshi Urabe
  • Yoshiki Kudo
ORIGINAL PAPER
First Online:
Received:
Accepted:

Abstract

Gestational trophoblastic disease (GTD) is a unique spectrum of diseases ranging from complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and invasive mole (IM) to choriocarcinoma (CC). Placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) have been classified as related disorders. Mesenchymal dysplasia (MD) may be misdiagnosed as PHM; however, it is said to have a quite different histogenesis from PHM. P57kip2 is the protein product of a paternally imprinted or maternal gene that inhibits cyclin-dependent kinases (CDK), thus serving to inhibit cell proliferation and to suppress tumor growth. Its lack of expression in trophoblastic disease plays a role in its abnormal proliferation and differentiation. In this study, P57kip2 immunostaining was absent in the trophoblastic layers of CHM and was positive in the trophoblast layer of nonmolar villi and MD. Ultrastructure of complete molar cystic villi showed tree-like branching of microvillous processes and intracytoplasmic lacunae without capillaries in the stroma, whereas MD contained many newly formed blood vessels and collagen. Also, large lacunae with microvilli and polymorphic nuclei of syncytiotrophoblast cells with well-developed organelles were observed in IM. Lung ETT following CHM and normal deliveries showed two types of large mononuclear cells and binuclear cells with abundant organelles and bundles of intermediate-type filaments in the stroma.

Key words

Mesenchymal dysplasia Hydatidiform mole P57 immunostaining Invasive mole Ultrastructure Choriocarcinoma Epithelioid trophoblastic tumor 
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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Hiroaki Soma
    • 1
  • Hiroyuki Osawa
    • 1
  • Tatsuo Oguro
    • 2
  • Isao Yoshihama
    • 3
  • Koji Fujita
    • 4
  • Shoichiro Mineo
    • 4
  • Motoshige Kudo
    • 4
  • Kayoko Tanaka
    • 5
  • Masumi Akita
    • 5
  • Satoshi Urabe
    • 6
  • Yoshiki Kudo
    • 6
  1. 1.Department of Obstetrics & GynecologySaitama Medical SchoolSaitamaJapan
  2. 2.Nihon Medical SchoolChiba Hokuso HospitalChibaJapan
  3. 3.Electron Microscopy SectionTokyo Medical UniversityTokyoJapan
  4. 4.Department of PathologyTokyo Medical UniversityTokyoJapan
  5. 5.Division of Morphological Science, Biomedical CenterSaitama Medical SchoolSaitamaJapan
  6. 6.Department of Obstetrics & GynecologyHiroshima UniversityHiroshimaJapan

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