Medical Molecular Morphology

, Volume 42, Issue 3, pp 185–188 | Cite as

Clear cell chondrosarcoma: an ultrastructural study

  • Naoto Kuroda
  • Toshiharu Sogoh
  • Masahiko Ohara
  • Takashi Hirouchi
  • Keiko Mizuno
  • Yoshihiro Hayashi
  • Gang-Hong Lee
Original Paper

Abstract

Clear cell chondrosarcoma (CCC) is a rare neoplasm. We report here a case of CCC. A 67-year-old Japanese man presented with right arthralgia for 1 year, and histological examination of the subsequent surgical resection of the right femoral bone showed the finding of CCC. Ultrastructurally, most organelles were observed in the perinuclear area. Clear neoplastic cells contained many glycogen particles in the area of the cytoplasm lacking organelles, although glycogen particles overall seemed to be evenly distributed in the cytoplasm. Some mitochondria, Golgi complex, actin-like filaments, and rough endoplasmic reticulum were also demonstrated in the cytoplasm of clear cells. Well-developed microvilli were also seen on the surface of neoplastic cells. These structures in neoplastic cells corresponded notably to structures of normal chondrocytes. Finally, our ultrastructural findings support further evidence that clear cells in CCC may show chondrocyte differentiation and a lack of an organelles area as well as abundant glycogen particles, may contribute to the clear cell morphology in CCC.

Key words

Clear cell chondrosarcoma Ultrastructure 

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References

  1. 1.
    Unni KK, Dahlin DC, Bullough PG, Sim FH (1976) Chondrosarcoma: clear cell variant. A report of sixteen cases. J Bone Joint Surg 58:676–683PubMedGoogle Scholar
  2. 2.
    Bjornsson J, Unni KK, Dahlin DC, Beabout JW, Sim FH (1984) Clear cell chondrosarcoma of bone: observation of 47 cases. Am J Surg Pathol 223–230Google Scholar
  3. 3.
    Charpentier YL, Forest M, Postel M, Tomeno B, Abelanet R (1979) Clear cell chondrosarcoma. A report of five cases including ultrastructural study. Cancer (Phila) 44:622–629CrossRefGoogle Scholar
  4. 4.
    Angervall L, Kindblom LG (1980) Clear cell chondrosarcoma. A light-and electron-microscopic and histochemical study of two cases. Virchows Arch A Pathol Anat Histol 389:27–41PubMedCrossRefGoogle Scholar
  5. 5.
    Faraggiana T, Sender B, Glicksman P (1981) Light- and electron-microscopic study of clear cell chondrosarcoma. Am J Clin Pathol 75:117–121PubMedGoogle Scholar
  6. 6.
    Lee SD, Ahn GH, Chi JG, Ham EK (1989) Clear cell chondrosarcoma: a case report. J Kor Med Sci 4:155–158Google Scholar
  7. 7.
    Carradi D, Bacchini P, Campanini N, Bertoni F (2006) Aggressive clear cell chondrosarcoma: do distinct characteristics exist? Arch Pathol Lab Med 130:1673–1679Google Scholar
  8. 8.
    McCarthy EF, Freemont A, Hogendoorn PCW (2002) Clear cell chondrosarcoma. In: Fletcher CDM, Unni KK, Mertens F (eds) World Heath Organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC Press, Lyon, pp 257–258Google Scholar
  9. 9.
    Godman G, Porter KR (1960) Chondrogenesis studied with the electron microscope. J Biophys Biochem Cytol 8:719–760PubMedCrossRefGoogle Scholar
  10. 10.
    Barnett CH, Cochrane W, Palfrey AJ (1963) Age changes in articular cartilage of rabbit. Ann Rheum Dis 22:389–399PubMedCrossRefGoogle Scholar
  11. 11.
    Palfrey AJ, Davies DV (1966) The fine structure of chondrocytes. J Anat 100:213–226PubMedGoogle Scholar
  12. 12.
    Ghadially FN, Metha PN, Kirkaldij-Willis WH (1970) Ultrastructure of articular cartilage in experimentally induced lipoarthrosis. J Bone Joint Surg 52:1147–1158PubMedGoogle Scholar
  13. 13.
    Erlandson RA, Huvos AG (1974) Chondrosarcoma: a light and electron microscopic study. Cancer (Phila) 34:1642–1652CrossRefGoogle Scholar
  14. 14.
    Fu YS, Key S (1974) A Comprehensive ultrastructural study of mesenchymal chondrosarcoma and myxoid chondrosarcoma. Cancer (Phila) 33:1531–1542CrossRefGoogle Scholar

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2009

Authors and Affiliations

  • Naoto Kuroda
    • 1
  • Toshiharu Sogoh
    • 2
  • Masahiko Ohara
    • 1
  • Takashi Hirouchi
    • 1
  • Keiko Mizuno
    • 1
  • Yoshihiro Hayashi
    • 3
  • Gang-Hong Lee
    • 3
  1. 1.Department of Diagnostic PathologyKochi Red Cross HospitalKochiJapan
  2. 2.Department of Orthopedic SurgeryKochi Red Cross HospitalKochiJapan
  3. 3.Department of Pathology, Kochi Medical SchoolKochi UniversityKochiJapan

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