Clear cell chondrosarcoma: an ultrastructural study
Clear cell chondrosarcoma (CCC) is a rare neoplasm. We report here a case of CCC. A 67-year-old Japanese man presented with right arthralgia for 1 year, and histological examination of the subsequent surgical resection of the right femoral bone showed the finding of CCC. Ultrastructurally, most organelles were observed in the perinuclear area. Clear neoplastic cells contained many glycogen particles in the area of the cytoplasm lacking organelles, although glycogen particles overall seemed to be evenly distributed in the cytoplasm. Some mitochondria, Golgi complex, actin-like filaments, and rough endoplasmic reticulum were also demonstrated in the cytoplasm of clear cells. Well-developed microvilli were also seen on the surface of neoplastic cells. These structures in neoplastic cells corresponded notably to structures of normal chondrocytes. Finally, our ultrastructural findings support further evidence that clear cells in CCC may show chondrocyte differentiation and a lack of an organelles area as well as abundant glycogen particles, may contribute to the clear cell morphology in CCC.
Key wordsClear cell chondrosarcoma Ultrastructure
Unable to display preview. Download preview PDF.
- 2.Bjornsson J, Unni KK, Dahlin DC, Beabout JW, Sim FH (1984) Clear cell chondrosarcoma of bone: observation of 47 cases. Am J Surg Pathol 223–230Google Scholar
- 6.Lee SD, Ahn GH, Chi JG, Ham EK (1989) Clear cell chondrosarcoma: a case report. J Kor Med Sci 4:155–158Google Scholar
- 7.Carradi D, Bacchini P, Campanini N, Bertoni F (2006) Aggressive clear cell chondrosarcoma: do distinct characteristics exist? Arch Pathol Lab Med 130:1673–1679Google Scholar
- 8.McCarthy EF, Freemont A, Hogendoorn PCW (2002) Clear cell chondrosarcoma. In: Fletcher CDM, Unni KK, Mertens F (eds) World Heath Organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC Press, Lyon, pp 257–258Google Scholar