Medical Molecular Morphology

, Volume 40, Issue 3, pp 168–171

Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures

  • Naoto Kuroda
  • Shin-ichi Iwamura
  • Nokiaki Fujishima
  • Masahiko Ohara
  • Takashi Hirouchi
  • Keiko Mizuno
  • Yoshihiro Hayashi
  • Gang-Hong Lee
ORIGINAL PAPER

Abstract

A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.

Key words

Anaplastic carcinoma Pancreas Hyaline globule-like structures Ultrastructure 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Paal, E, Thompson, LDR, Frommelt, RA, Przygodzki, RM, Heffess, CS 2001A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literatureAnn Diagn Pathol5129140PubMedCrossRefGoogle Scholar
  2. 2.
    Kuroda, N, Sawada, T, Miyazaki, E, Hayashi, Y, Toi, M, Naruse, K, Fukui, T, Nakayama, H, Hiroi, M, Taguchi, H, Enzan, H 2000Anaplastic carcinoma of the pancreas with rhabdoid featuresPathol Int505762PubMedCrossRefGoogle Scholar
  3. 3.
    Solcia, E, Capella, C, Kloppel, G 1997

    Undifferentiated (anaplastic) carcinoma. Tumors of the pancreas

    Atlas of tumor pathology, 3rd seriesArmed Forces Institute of PathologyWashington, DC9193
    Google Scholar
  4. 4.
    Perez-Montiel, MD, Frankel, WL, Suster, S 2003Neuroendocrine carcinoma of the pancreas with “rhabdoid” featuresAm J Surg Pathol27642649PubMedCrossRefGoogle Scholar
  5. 5.
    Chetty, R, Asa, SL 2004Pancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term “rhabdoid” appropriate?J Clin Pathol5711061110PubMedCrossRefGoogle Scholar
  6. 6.
    Kuroda, N, Satake, H, Miyazaki, E, Hayashi, Y, Hiroi, H, Enzan, H 2004Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features in adult polycystic kidney disease: a case reportInt J Surg Pathol12171177PubMedCrossRefGoogle Scholar
  7. 7.
    Danbara, N, Shikata, N, Kawamura, H, Shintaku, M, Tsubura, A 2005Eosinophilic cytoplasmic inclusions in papillary renal cell carcinomaMed Mol Morphol38262266PubMedCrossRefGoogle Scholar
  8. 8.
    Rosario, AD, Bui, HX, Singh, J, Ginsburg, R, Ross, JS 1994Intracytoplasmic eosinophilic hyaline globules in cartilaginous neoplasms: a surgical, pathological, ultrastructural, and electron probe X-ray microanalytic studyHum Pathol2512831289PubMedCrossRefGoogle Scholar
  9. 9.
    Dai, CL, Xu, F, Shu, H, Xu, YQ, Huang, Y 2005Undifferentiated (embryonal) sarcoma of liver in adult: a case reportWorld J Gastroenterol11926929PubMedGoogle Scholar
  10. 10.
    Stumptner, C, Heid, H, Fuchsbichler, A, Hauser, H, Mischiger, HJ, Zatloukal, K, Denk, H 1995Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinomaAm J Pathol15417011710Google Scholar
  11. 11.
    Gonzalez-Campora, R, Escudero, AG, Martin, JJR, Pardon, JRA, Vazquez, AH, Ramirez, FJV 2003Myofibrosarcoma (low-grade myofibroblastic sarcoma) with intracytoplasmic hyaline (fibroma-like) inclusion bodiesUltrastruct Pathol27711PubMedCrossRefGoogle Scholar
  12. 12.
    Krishnan, B, Truong, LD 2002Renal epithelial neoplasms: the diagnostic implications of electron microscopic study in 55 casesHum Pathol336879PubMedCrossRefGoogle Scholar
  13. 13.
    Weaver, MG, Abdul-Karim, FW, Srigley, J, Bostwick, DG, Ro, JY, Ayala, AG 1992Paneth cell-like change of the prostatic gland. A histological, immunohistochemical, and electron microscopic studyAm J Surg Pathol166268PubMedCrossRefGoogle Scholar
  14. 14.
    Kuroda, N, Inui, Y, Ohara, M, Hirouchi, T, Mizuno, K, Kubo, A, Hayashi, Y, Enzan, H, Lee, GH 2007Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the Fallopian tubeMed Mol Morphol404649PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Naoto Kuroda
    • 1
  • Shin-ichi Iwamura
    • 2
  • Nokiaki Fujishima
    • 3
  • Masahiko Ohara
    • 1
  • Takashi Hirouchi
    • 1
  • Keiko Mizuno
    • 1
  • Yoshihiro Hayashi
    • 4
  • Gang-Hong Lee
    • 4
  1. 1.Departments of Pathology and Laboratory MedicineKochi Red Cross HospitalKochi CityJapan
  2. 2.Department of Internal MedicineKochi Red Cross HospitalKochiJapan
  3. 3.Department of SurgeryKochi Red Cross HospitalKochiJapan
  4. 4.Department of Pathology, Program of Bioregulation and GeneticsKochi Medical School, Kochi UniversityKochiJapan

Personalised recommendations