Medical Molecular Morphology

, Volume 40, Issue 1, pp 1–7 | Cite as

Molecular morphology of the digestive tract; macromolecules and food allergens are transferred intact across the intestinal absorptive cells during the neonatal-suckling period

  • Mamoru Fujita
  • Ryoko Baba
  • Mariko Shimamoto
  • Yoshiko Sakuma
  • Sunao Fujimoto
SPECIAL REVIEW SERIES: Molecular morphological approach for pathogenesis of hepatogastrointestinal diseases


Food allergies represent an important medical problem throughout the developed world. The epithelium of the digestive tract is an important area of contact between the organism and its external environment. Accordingly, we must reconsider the transport of intestinal transepithelial macromolecules, including food allergens, in vivo. The intestinal epithelium of the neonatal-suckling rat is a useful model system for studies into endocytosis and transcytosis. Macromolecules and food allergens can be transferred intact with maternal immunoglobulins across the absorptive cells of duodenum and jejunum during the neonatal-suckling period. This review summarizes these observations as well as our recent molecular morphological studies.

Key words

Neonatal-suckling Small intestine Duodenum Jejunum Ileum Absorptive cells Endocytosis Transcytosis Macromolecule Food allergen 


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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Mamoru Fujita
    • 1
  • Ryoko Baba
    • 1
  • Mariko Shimamoto
    • 1
  • Yoshiko Sakuma
    • 1
  • Sunao Fujimoto
    • 1
  1. 1.Graduate School of Health and Nutrition SciencesNakamura Gakuen UniversityFukuokaJapan

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