Medical Molecular Morphology

, Volume 38, Issue 3, pp 136–141

Recruitment of dendritic cells to pathological niches in inflamed liver

SPECIAL REVIEW SERIES: New ultrastructural discoveries in the pathophysiology of liver diseases

DOI: 10.1007/s00795-005-0289-0

Cite this article as:
Yoneyama, H. & Ichida, T. Med Mol Morphol (2005) 38: 136. doi:10.1007/s00795-005-0289-0


The liver is a specialized organ for host defense and immunity. Recruitment of dendritic cells (DCs) is crucial to host defense in a granulomatous liver disease in mice. In response to danger signals, DC precursors are mobilized de novo into the circulation. Myeloid DC (mDC) precursors are recruited to perisinusoidal spaces and activated to form granulomas. Recruited mDCs subsequently extravasate into Disse’s space and migrate to the portal area to induce portal tract-associated lymphoid tissue (PALT). Some mDCs are remobilized into draining hepatic lymph nodes (LNs) to prime antigen-specific CD4+ helper T cells. Kupffer cell-derived CCL3/MIP-1α attracts mDC precursors to the sinusoidal granulomas, whereas PALT composed cell-derived CCL21/SLC attracts activated mDCs to the T-cell zone of PALT. Inflammatory cytokines modulate this sinusoid-portal migration through IL-1R/TLR signaling. Recruited mDCs themselves also produce several chemokines and cytokines that modulate T-cell responses. A unique trafficking of circulating mDC precursors within the inflammation-associated, newly formed compartments (“pathological niches”) is strictly regulated by both homeostatic and inducible chemokines and determines the final efficiency of the immunity in this organ.

Key words

Dendritic cell Chemokine Granuloma Kupffer cell T cell 

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2005

Authors and Affiliations

  1. 1.Department of Molecular Preventive Medicine, School of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of GastroenterologyJuntendo University School of Medicine, Shizuoka HospitalShizuokaJapan

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