Thermophilic microorganisms as well as acetogenic bacteria are both considered ancient. Interestingly, only a few species of bacteria, all belonging to the family Thermoanaerobacteraceae, are described to conserve energy from acetate formation with hydrogen as electron donor and carbon dioxide as electron acceptor. This review reflects the metabolic differences between Moorella spp., Thermoanaerobacter kivui and Thermacetogenium phaeum, with focus on the biochemistry of autotrophic growth and energy conservation. The potential of these thermophilic acetogens for biotechnological applications is discussed briefly.
KeywordsAcetogenesis Thermophiles Thermoanaerobacter kivui Moorella thermoacetica Thermacetogenium phaeum Wood-Ljungdahl pathway CODH/ACS
CO dehydrogenase/acetyl-CoA synthase
Energy converting hydrogenase
We would like to thank the Deutsche Forschungsgemeinschaft (DFG) for generous support.
- Drake HL (1994) Acetogenesis. Chapman & Hall, New YorkGoogle Scholar
- Tremblay P-L, Zhang T, Dar SA, Leang C, Lovley DR (2013) The Rnf complex of Clostridium ljungdahlii is a proton-translocating ferredoxin:NAD+ oxidoreductase essential for autotrophic growth. Mbio 4:e00406–e00412Google Scholar
- Wiegel J (2009) Genus Moorella. In: De Vos P et al (eds) Bergey’s manual of systematic bacteriology, vol 3: the firmicutes, 2nd edn. Springer, New York, pp 1247–1253Google Scholar
- Zheng YN, Kahnt J, Kwon IH, Mackie RI, Thauer RK (2014) Hydrogen formation and its regulation in Ruminococcus albus: involvement of an electron-bifurcating [FeFe]-hydrogenase, of a non-electron-bifurcating [FeFe]-hydrogenase, and of a putative hydrogen-sensing [FeFe]-hydrogenase. J Bacteriol 196:3840–3852CrossRefPubMedPubMedCentralGoogle Scholar