Attenuated neural reactivity to happy faces is associated with rule breaking and social problems in anxious youth
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Pediatric anxiety is associated with comorbid externalizing behaviors and social problems, and these associations may be related to altered emotion processing. The late positive potential (LPP), an event-related potential component, is a neural marker of emotion processing, and there is evidence that anxious youth exhibits enhanced LPPs to threatening signals. It is unknown, however, if differences in the LPP are related to externalizing behaviors and social problems co-occurring with anxiety and if these associations are driven by altered processing of threatening (angry or fearful faces) or rewarding (happy faces) socio-emotional signals. Thus, in the present study, we examined, in a sample of 39 anxious youth, the association between LPPs, following socio-emotional signals and externalizing behaviors and social problems. Results indicated an association between attenuated LPPs in response to happy faces and greater rule-breaking and social problems. These findings suggest that differences in positive socio-emotional signal processing are related to heterogeneity in pediatric anxiety and that LPPs are a sensitive index of such heterogeneity.
KeywordsAnxiety Rule breaking Social problems Event-related potential (ERP) Late positive potential (LPP) Positive socio-emotional signal processing
This study was supported by the National Institutes of Health (R01MH086517 to KLP and CSM). AK is supported by a training grant from the National Institutes of Health (T32MH067631 to Mark Rasenick).
Compliance with ethical standards
Conflict of interest
We declare that we have no conflict of interest.
- 40.Forslund T, Brocki KC, Bohlin G, Granqvist P, Eninger L (2016) The heterogeneity of attention-deficit/hyperactivity disorder symptoms and conduct problems: cognitive inhibition, emotion regulation, emotionality, and disorganized attachment. Br J Dev Psychol. doi: 10.1111/bjdp.12136 PubMedGoogle Scholar
- 44.Hajcak G, Weinberg A, MacNamara A, Foti D (2011) ERPs and the study of emotion. In: Luck SJ, Kappenman E (eds) Handbook of event-related potential components. Oxford University Press, New York, pp 441–472Google Scholar
- 58.Achenbach TM, Rescorla LA (2001) Manual for the ASEBA school-age forms & profiles: An integrated system of multi-informant assessment. Research Center for Children, Youth and Families, University of Vermont, BurlingtonGoogle Scholar
- 59.Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMedGoogle Scholar
- 65.Cumming G (2013) Understanding the new statistics: effect sizes, confidence intervals, and meta-analysis. NY: Routledge, New York, pp 1–5Google Scholar
- 66.Field A (2013) Discovering statistics using IBM SPSS statistics. CA: Sage, Thousand Oaks, p 53Google Scholar
- 69.Watson P (2016) Rules of thumb on magnitudes of effect sizes. Retrieved from: http://imaging.mrc-cbu.cam.ac.uk/statswiki/FAQ/effectSize. Accessed 5 Mar 2016
- 74.Gatzke-Kopp LM, Beauchaine TP (2007) Central nervous system substrates of impulsivity. In: Coch D, Dawson G, Fischer K (eds) Human behavior, learning, and the developing brain: atypical development. The Guilford Press, New York, pp 239–263Google Scholar
- 76.Öhman A, Ham OA, Hugdhal K (2000) Cognition and the autonomic nervous system. Orienting, anticipation, and conditioning. In: Cacioppo JT, Tassinary LG, Berntson GG (eds) Handbook of psychophysiology. Cambridge University Press, New York, pp 533–575Google Scholar
- 78.Klumpp H, Fitzgerald DA, Piejko K, Roberts J, Kennedy AE, Phan KL (2015) Prefrontal control and predictors of cognitive behavioral therapy tesponse in social anxiety disorder. Soc Cogn Affect Neurosci. doi: 10.1093/scan/nsv146
- 80.van Rooij D, Hoekstra PJ, Mennes M, von Rhein D, Thissen AJ, Heslenfeld D, Hartman CA (2015) Distinguishing adolescents with ADHD from their unaffected siblings and healthy comparison subjects by neural activation patterns during response inhibition. Am J Psychiatry 172:674–683CrossRefPubMedPubMedCentralGoogle Scholar