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European Child & Adolescent Psychiatry

, Volume 24, Issue 5, pp 537–544 | Cite as

The relationship between premorbid body weight and weight at referral, at discharge and at 1-year follow-up in anorexia nervosa

  • Manuel FöckerEmail author
  • Katharina Bühren
  • Nina Timmesfeld
  • Astrid Dempfle
  • Susanne Knoll
  • Reinhild Schwarte
  • Karin Maria Egberts
  • Ernst Pfeiffer
  • Christian Fleischhaker
  • Christoph Wewetzer
  • Johannes Hebebrand
  • Beate Herpertz-Dahlmann
Original Contribution

Abstract

Body mass index (BMI) is one of the most important outcome predictors in patients with anorexia nervosa (AN). A low premorbid BMI percentile calculated by the patients recalled premorbid weight and the height at first admission has been found to predict the BMI at first inpatient admission. In this study, we sought to confirm this relationship. We additionally analyze the relationship between premorbid BMI percentile and BMI percentile at discharge from the first inpatient treatment and at 1-year follow-up or alternatively if applicable upon readmission within this time period. We included 161 female patients aged 11–18 years of the multisite ANDI-trial with a DSM-IV diagnosis of AN. We used a multivariate statistical model including the independent variables age, duration of illness, duration of treatment, BMI at admission and BMI percentile at discharge. The relationship between premorbid BMI percentile and BMI at admission was solidly confirmed. In addition to premorbid BMI percentile, BMI at admission and age were significant predictors of BMI percentile at discharge. BMI percentile at discharge significantly predicted BMI percentile at 1-year follow-up. An additional analysis that merely included variables available upon referral revealed that premorbid BMI percentile predicts the 1-year follow-up BMI percentile. Further studies are required to identify the underlying biological mechanisms and to address the respective treatment strategies for AN patients with a low or high premorbid BMI percentile.

Keywords

Anorexia nervosa BMI Premorbid BMI Outcome ANDI Tracking 

Notes

Acknowledgments

This study was funded by the German Ministry for Education and Research (Grants 01GV0602 and 01GV0623).

Conflict of interest

Christian Fleischhaker received grants from Bristol-Myers-Squibb, Novartis, Shire and Pfizer; Beate Herpertz-Dahlmann has received industry research funding from Medice and Vifor; Johannes Hebebrand received grants by Lilly GmbH Germany (speaker’s honorarium). Ernst Pfeiffer has received speakers fee from Infectopharm; Christoph Wewetzer has received industry research funding from Shire. Katharina Bühren, Astrid Dempfle, Karin Maria Egberts, Manuel Föcker, Susanne Knoll, Reinhild Schwarte and Nina Timmesfeld report no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Manuel Föcker
    • 1
    Email author
  • Katharina Bühren
    • 2
  • Nina Timmesfeld
    • 3
  • Astrid Dempfle
    • 3
  • Susanne Knoll
    • 1
  • Reinhild Schwarte
    • 2
  • Karin Maria Egberts
    • 4
  • Ernst Pfeiffer
    • 5
  • Christian Fleischhaker
    • 6
  • Christoph Wewetzer
    • 7
  • Johannes Hebebrand
    • 1
  • Beate Herpertz-Dahlmann
    • 2
  1. 1.Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyUniversity Hospital Essen, University of Duisburg-EssenEssenGermany
  2. 2.Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyUniversity Hospital of the RWTH AachenAachenGermany
  3. 3.Institute of Medical Biometry and EpidemiologyPhilipps-University MarburgMarburgGermany
  4. 4.Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyUniversity Hospital WürzburgWürzburgGermany
  5. 5.Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyCharitéBerlinGermany
  6. 6.Department of Child and Adolescent Psychiatry and PsychotherapyUniversity Medical Center FreiburgFreiburgGermany
  7. 7.Department of Child and Adolescent Psychiatry and PsychotherapyKliniken der Stadt KölnCologneGermany

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