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European Child & Adolescent Psychiatry

, Volume 23, Issue 10, pp 957–971 | Cite as

Antenatal depression and children’s developmental outcomes: potential mechanisms and treatment options

  • Cerith S. Waters
  • Dale F. Hay
  • Jessica R. Simmonds
  • Stephanie H. M. van Goozen
Review

Abstract

During the last decade there has been increased recognition of the prevalence of antenatal depression as well as an expansion in research examining the impact of maternal mood during pregnancy on offspring development. The aim of this review was to summarise the theoretical underpinnings and empirical evidence regarding the impact of antenatal depression on children’s developmental outcomes. Biological mechanisms hypothesised to account for an association between antenatal depression and adverse offspring outcomes are first identified including the functioning of the prenatal Hypothalamic Pituitary Adrenal (HPA) axis and epigenetic processes. A systematic literature search is then conducted of studies examining the impact of antenatal depression on child development. In general, studies examining associations between antenatal depression and offspring temperament, cognitive and emotional outcomes reveal either no effect of the prenatal environment or small effects that often attenuate following adjustment for other antenatal and postnatal risk factors. In contrast, an independent effect of antenatal depression on children’s conduct problems and antisocial behaviour is a well-replicated finding. There is emerging evidence that exposure to depression during pregnancy impacts negatively on offspring biology, although the findings are complex and require replication. Psychological and pharmacological treatments of antenatal depression are then reviewed, considering whether antidepressant medication exerts harmful effects on the foetus. We close by proposing that antenatal depression is an early marker of a developmental cascade to future mental health problems for both mothers and offspring.

Keywords

Prenatal depression HPA axis Mechanisms Treatment Child outcomes 

Notes

Conflict of interest

None.

References

  1. 1.
    Buist A (2000) Managing depression in pregnancy. Aust Fam Phys 29:663–667Google Scholar
  2. 2.
    O’Keane V (2006) Mood disorder during pregnancy: aetiology and management. In: O’Keane V, Marsh M, Seneviratne G (eds) Psychiatric disorders and pregnancy. Taylor & Francis, London, pp 69–105Google Scholar
  3. 3.
    Murray L, Cooper PJ (1997) Postpartum depression and child development. Guilford Press, LondonGoogle Scholar
  4. 4.
    O’Hara MW, McCabe JE (2013) Postpartum depression: current status and future directions. Annu Rev Clin Psychol 9:379–407PubMedGoogle Scholar
  5. 5.
    Heron J, O’Conner TG, Evans J et al (2004) The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord 80:65–73PubMedGoogle Scholar
  6. 6.
    Pawlby S, Hay DF, Sharp D et al (2009) Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study. J Affect Disord 113:236–243PubMedGoogle Scholar
  7. 7.
    American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, ArlingtonGoogle Scholar
  8. 8.
    World Health Organization Division of Mental Health (1992) WHO SCAN Advisory Committee. SCAN Schedules for Clinical Assessment in Neuropsychiatry, version 1.0. Schedules for Clinical Assessment in Neuropsychiatry. Distribution from training centres. WHO, GenevaGoogle Scholar
  9. 9.
    Bennett HA, Einarson A, Taddio A et al (2004) Prevalence of depression during pregnancy: systematic review. Am Coll Obstet Gynaecol 103:698–709Google Scholar
  10. 10.
    Gavin NI, Gaynes BN, Lohr KN et al (2005) Perinatal depression. A systematic review of prevalence and incidence. Am J Obstet Gynaecol 106:1071–1083Google Scholar
  11. 11.
    Waters CS, Pawlby S, van Goozen S, Hay DF (2014) Young motherhood, perinatal depression, and children’s developmental outcomes. In: Pariante et al (eds) Perinatal psychiatry: the legacy of Channi Kumar. Oxford University Press, Oxford, pp 175–194Google Scholar
  12. 12.
    Marcus SM, Flynn HA, Blow FC et al (2003) Depressive symptoms among pregnant women screened in obstetric settings. J Women’s Health 12:373–380Google Scholar
  13. 13.
    Rich-Edwards JW, Kleinman K, Abrams A et al (2006) Socio-demographic predictors of antenatal and postpartum depressive symptoms among women in a medical group practice. J Epidemiol Commun Health 60:221–227Google Scholar
  14. 14.
    Leigh B, Milgrom J (2008) Risk factors for antenatal depression, postnatal depression and parenting stress. BMC Psychiatry 8:24PubMedPubMedCentralGoogle Scholar
  15. 15.
    Lancaster CA, Gold KJ, Flynn Ha et al (2010) Risk factors for depressive symptoms during pregnancy: a systematic review. Am J Obstet Gynaecol 202:5–14Google Scholar
  16. 16.
    Plant DT, Barker ED, Waters CS et al (2012) Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression. Psychol Med 43:519–528PubMedPubMedCentralGoogle Scholar
  17. 17.
    Chou FH, Lin LL, Cooney AT et al (2003) Psychosocial factors related to nausea, vomiting and fatigue in early pregnancy. J Nurs Scholarsh 35:119–125PubMedGoogle Scholar
  18. 18.
    Larsson C, Sydsjo G, Joefsson A (2004) Health, socio-demographic data and pregnancy outcome in women with antepartum depressive symptoms. Am Coll Obstet Gynaecol 104:459–466Google Scholar
  19. 19.
    Benediktsson R, Seckl JR (1998) Understanding human parturition. Lancet 344:77–81Google Scholar
  20. 20.
    Talge NM, Neal C, Glover V et al (2007) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 48:245–261PubMedGoogle Scholar
  21. 21.
    Weinstock M (2005) The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun 19:296–308PubMedGoogle Scholar
  22. 22.
    Huizink AC, Mulder EJ, Buitelaar JK (2004) Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility? Psychol Bull 130:115–142PubMedGoogle Scholar
  23. 23.
    Cottrell EC, Seckl JR (2009) Prenatal stress, glucocorticoids and the programming of adult disease. Front Behav Neurosci 3:19PubMedPubMedCentralGoogle Scholar
  24. 24.
    Welberg LAM, Thrivikraman KV, Plotsky PM (2005) Chronic maternal stress inhibits the capacity to up-regulate placental 11B-hydroxysteroid hydrogenase type II activity. J Endocrinol 186:7–12Google Scholar
  25. 25.
    Baibazarova E, van de Beek C, Cohen-Kettenis PT et al (2013) Influence of prenatal maternal stress, maternal plasma cortisol and cortisol in the amniotic fluid on birth outcomes and child temperament at 3 months. Psychoneuroendocrinology 38:907–915PubMedGoogle Scholar
  26. 26.
    Sarkar S, Tsai SW, Nguyen TT et al (2001) Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling. Am J Physiol Regul Integr Comp Physiol 281:1966–1974Google Scholar
  27. 27.
    Field T, Diego M, Hernandez-Reif M (2010) Prenatal depression effects and interventions: a review. Infant Behav Dev 33:409–418PubMedPubMedCentralGoogle Scholar
  28. 28.
    Monk C, Fifer WP, Myers MM et al (2011) Effects of maternal breathing rate, psychiatric status, and cortisol on fetal heart rate. Dev Psychobiol 53:221–233PubMedPubMedCentralGoogle Scholar
  29. 29.
    Emory E, Dieter J (2006) Maternal depression and psychotropic medication effects on the human fetus. Ann N Y Acad Sci 10:12–15Google Scholar
  30. 30.
    Davis EP, Glynn LM, Waffarn L, Sandman CA (2011) Prenatal maternal stress programs infant stress regulation. J Child Psychol Psychiatry 52:119–129PubMedPubMedCentralGoogle Scholar
  31. 31.
    Buss C, Davis EP, Shahbaba B et al (2010) Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci USA 109:1312–1319Google Scholar
  32. 32.
    Davis EP, Glynn LM, Schetter CD (2007) Prenatal exposure to maternal depression and cortisol influences infant temperament. Am Acad Child Adolesc Psychiatry 46:737–746Google Scholar
  33. 33.
    Werner E, Zhao Y, Evans L (2012) Higher prenatal maternal cortisol and younger age predict greater infant reactivity to novelty at 4 months: an observation-based study. Dev Psychobiol 55:707–718PubMedGoogle Scholar
  34. 34.
    LeWinn KZ, Stroud LR, Molnar BE et al (2009) Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ. Int J Epidemiol 38:1700–1710PubMedPubMedCentralGoogle Scholar
  35. 35.
    Davis EP, Sandman CA (2012) Prenatal psychobiological predictors of anxiety risk in preadolescent children. Psychoneuroendocrinology 37:1224–1233PubMedPubMedCentralGoogle Scholar
  36. 36.
    Rothenberger SE, Resch F, Doszpod N, Moehler E (2011) Prenatal stress and infant affective reactivity at five months of age. Early Hum Dev 87:129–136PubMedGoogle Scholar
  37. 37.
    Field T, Diego M, Hernandez-Reif M (2006) Prenatal depression effects on the fetus and newborn: a review. Infant Behav Dev 29:445–455PubMedGoogle Scholar
  38. 38.
    Kinsella BA, Monk C (2009) Impact of maternal stress, depression and anxiety on fetal neurobehavioural development. Clin Obstet Gynecol 52:425–440PubMedPubMedCentralGoogle Scholar
  39. 39.
    Teixeira J, Fisk N, Glover V (1999) Association between maternal anxiety in pregnancy and increased uterine artery resistance index: cohort based study. BMJ 318:153–157PubMedPubMedCentralGoogle Scholar
  40. 40.
    Champagne FA (2010) Epigenetic influence of social experiences across the lifespan. Dev Psychobiol 52:299–311PubMedGoogle Scholar
  41. 41.
    Monk C, Spicer J, Champagne FA (2012) Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways. Dev Psychopathol 24:1361–1376PubMedPubMedCentralGoogle Scholar
  42. 42.
    Radtke KM, Ruf M, Gunter HM et al (2011) Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 1(7):e21PubMedPubMedCentralGoogle Scholar
  43. 43.
    Oberlander TF, Weinberg J, Papsdorf M et al (2008) Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 3:97–106PubMedGoogle Scholar
  44. 44.
    Devlin AM, Brain U, Austin J, Oberlander TF (2010) Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 5:e12201PubMedPubMedCentralGoogle Scholar
  45. 45.
    O’Donnell KJ, Bugge JA, Freeman L et al (2011) Maternal prenatal anxiety and downregulation of placental 11beta-HSD2. Psychoneuroendicrinology 37:818–826Google Scholar
  46. 46.
    Borzsonyi B, Demendi C, Pajor A et al (2012) Gene expression patterns of the 11 beta-hydroxysteroid dehydrogenase 2 enzyme in human placenta from intrauterine growth restriction: the role of impaired feto-maternal glucocorticoid metabolism. Eur J Obstet Gynaecol Reprod Biol 161:12–17Google Scholar
  47. 47.
    Silberg JL, Maes H, Eaves LJ (2010) Genetic and environmental influences on the transmission of parental depression to children’s depression and conduct disturbance: an extended Children of Twins study. J Child Psychol Psychiatry 51:734–744PubMedPubMedCentralGoogle Scholar
  48. 48.
    Lovejoy MC, Graczyk PA, O’Hare E, Neuman G (2000) Maternal depression and parenting behaviour. Clin Psychol Rev 20:561–592PubMedGoogle Scholar
  49. 49.
    Kim-Cohen J, Moffitt TE, Taylor A et al (2005) Maternal depression and child antisocial behaviour: nature and nurture effects. Arch Gen Psychiatry 62:173–181PubMedGoogle Scholar
  50. 50.
    Kendler KS, Gatz M, Gardner CO, Pedersen NL (2006) A Swedish national twin study of lifetime major depression. Am J Psychiatry 163:109–114PubMedGoogle Scholar
  51. 51.
    Rice F, Harold GT, Thapar A (2002) The genetic aetiology of childhood depression: a review. J Child Psychol Psychiatry 43:65–79PubMedGoogle Scholar
  52. 52.
    Rice F, Lewis G, Harold GT, Thapar A (2013) Examining the role of passive gene-environment correlation in childhood depression using a novel genetically sensitive design. Dev Psychopathol 25:37–50PubMedGoogle Scholar
  53. 53.
    Maccari S, Piazza PV, Kabbaj M et al (1995) Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. J Neurosci 15:110–116PubMedGoogle Scholar
  54. 54.
    Bergman K, Sarkar P, Glover V, O’Connor TG (2008) Quality of attachment moderates the impact of antenatal stress on child fearfulness. J Child Psychol Psychiatry 49:1089–1098PubMedPubMedCentralGoogle Scholar
  55. 55.
    Leung BMY, Kaplan BJ (2009) Perinatal depression: prevalence, risks, and the nutrition link—a review of the literature. J Am Diet Assoc 109:1566–1575PubMedGoogle Scholar
  56. 56.
    Rice F, Harold GT, Boivin J, Van den Bree M et al (2010) The links between prenatal stress and offspring development and psychopathology: disentangling environment and inherited influences. Psychol Med 40:335–345PubMedPubMedCentralGoogle Scholar
  57. 57.
    Higgins J, Green S (2009) Cochrane handbook for systematic reviews of interventions, version 5.0. 2 (updated September 2009). The Cochrane Collaboration, New YorkGoogle Scholar
  58. 58.
    Beijers R, Buitelaar J, de Weerth C (2014) Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis. Eur Child Adolesc Psychiatry [Epub ahead of print]Google Scholar
  59. 59.
    Von Elm E, Altman DG, Egger M, Pocock SJ et al (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344–349PubMedGoogle Scholar
  60. 60.
    Luoma I, Tamminen T, Kaukonen P et al (2001) Longitudinal study of maternal depressive symptoms and child well-being. J Am Acad Child Adolesc Psychiatry 40:1367–1374PubMedGoogle Scholar
  61. 61.
    Davis PE, Snidman N, Wadwa P et al (2004) Prenatal anxiety and depression predict negative behaviour reactivity in infancy. Infancy 6:319–331Google Scholar
  62. 62.
    Austin MP, Hazdi-Pavlovic D, Leader L et al (2005) Maternal trait anxiety, depression and life event stress in pregnancy: relationships with infant temperament. Early Hum Dev 81:183–190PubMedGoogle Scholar
  63. 63.
    Leech SL, Larkby CA, Day R, Day N (2006) Predictors and correlates of high levels of depression and anxiety symptoms among children at age 10. J Am Acad Child Adolesc Psychiatry 45:223–230PubMedGoogle Scholar
  64. 64.
    Hay DF, Pawlby S, Waters CS, Sharp D (2008) Antepartum and postpartum exposure to maternal depression: different effects on different adolescent outcomes. J Child Psychol Psychiatry 49:1079–1088PubMedGoogle Scholar
  65. 65.
    Deave T, Heron J, Emond A (2008) The impact of maternal depression in pregnancy on early child development. Int J Obstet Gynaecol 115:1043–1051Google Scholar
  66. 66.
    Hay DF, Pawlby S, Waters CS et al (2010) Mothers’ antenatal depression and their children’s antisocial outcomes. Child Dev 81:149–165PubMedGoogle Scholar
  67. 67.
    Tse AC, Rich-Edwards JW, Rifas-Shman SL et al (2010) Association of maternal prenatal depressive symptoms with child cognition at age 3 years. Paediatr Perinat Epidemiol 24:232–240PubMedPubMedCentralGoogle Scholar
  68. 68.
    Hanington L, Heron J, Stein A, Ramchandi P (2011) Prenatal depression and child outcomes—is marital conflict the missing link? Child Care Health Dev 38:520–529PubMedGoogle Scholar
  69. 69.
    Barker ED, Jaffee SR, Uher R, Maughan B (2011) The contribution of prenatal and postnatal maternal anxiety and depression to child maladjustment. Depress Anxiety 28:696–702PubMedGoogle Scholar
  70. 70.
    Hay DF, Mundy L, Roberts S et al (2011) Known risk factors for violence predict 12 month old infants aggressiveness with peers. Psychol Sci 22:1205–1211PubMedGoogle Scholar
  71. 71.
    Laurent HK, Ablow JC, Measelle J (2011) Risky shifts: how the timing and course of mothers’ depressive symptoms across the perinatal period shape their own and infant’s stress response profiles. Dev Psychopathol 23:521–538PubMedGoogle Scholar
  72. 72.
    Evans J, Melotti R, Heron J et al (2012) The timing of maternal depressive symptoms and child cognitive development: a longitudinal study. J Child Psychol Psychiatry 53:632–640PubMedGoogle Scholar
  73. 73.
    Korhonen M, Luoma I, Salmelin R, Tamminen T (2012) A longitudinal study of maternal prenatal, postnatal and concurrent depressive symptoms and adolescent well-being. J Affect Disord 136:680–692PubMedGoogle Scholar
  74. 74.
    Koutra K, Chatzi L, Bagkeris M et al (2012) Antenatal and postnatal maternal mental health as determinants of infant neurodevelopment at 18 months of age in mother–child cohort (Rhea study) in Crete, Greece. Soc Psychiatry Epidemiol 48:1335Google Scholar
  75. 75.
    Van Batenburg-Eddes T, Brion MJ, Henrichs J et al (2013) Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J Child Psychol Psychiatry 54:591–600PubMedPubMedCentralGoogle Scholar
  76. 76.
    Werner A et al (2012) Solomon, R.L., & Lessac, M.S. (1968). A control group design for experimental studies of developmental processes. Psychol Bull 70:145–160Google Scholar
  77. 77.
    Vedhara K, Metcafe C, Brant H et al (2012) Maternal mood and neuroendocrine programming: effects of time of exposure and sex. J Neuroendocr 24:999–1011Google Scholar
  78. 78.
    Bolten M, Nast I, Skrundz M et al (2013) Prenatal programming of emotion regulation. J Psychosom Res 75:351–357PubMedGoogle Scholar
  79. 79.
    Leis JA, Heron J, Stuart EA, Mendelson T (2013) Associations between maternal mental health and child emotional and behavioural problems: does prenatal mental health matter? J Abnorm Child Psychol 42:161–171Google Scholar
  80. 80.
    O’Donnell KJ, Glover V, Jenkins J et al (2013) Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. J Psychoneuroendocr 38:1630–1638Google Scholar
  81. 81.
    Rifkin-Graboi A, Bai J, Chen H et al (2013) Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth. Biol Psychiatry 74:837–844PubMedGoogle Scholar
  82. 82.
    Waters CS, van Goozen S, Phillips R et al (2013) Infants at familial risk for depression show a distinct pattern of cortisol response to experimental challenge. J Affect Disord 150:955–960PubMedGoogle Scholar
  83. 83.
    Solomon RL, Lessac MS (1968) A control group design for experimental studies of developmental processes. Psychol Bull 70:145–160PubMedGoogle Scholar
  84. 84.
    Pawlby S, Hay D, Sharp D et al (2011) Antenatal depression and offspring psychopathology: the influence of childhood maltreatment. Br J Psychiatry 199:106–122PubMedGoogle Scholar
  85. 85.
    Thapar A, Rutter M (2009) Do prenatal risk factors cause psychiatric disorder? Be wary of causal claims. Br J Psychiatry 195:100–101PubMedGoogle Scholar
  86. 86.
    Kaplan LA, Evans L, Monk C (2008) Effects of mothers’ prenatal psychiatric status and postnatal caregiving on infant biobehavioural regulation: can prenatal programming be modified? Early Hum Dev 84:249–256PubMedPubMedCentralGoogle Scholar
  87. 87.
    Healy D, Mangin D, Mintzes B (2010) The ethics of a randomized placebo controlled trials of antidepressants with pregnant women. Int J Risk Saf Med 22:7–16Google Scholar
  88. 88.
    National Institute for Health and Clinical Excellence (2009) Clinical guideline 90. Depression in adults: the treatment and man agreement of depression in adults. National Institute for Health and Clinical Excellence, LondonGoogle Scholar
  89. 89.
    Spinelli M (2012) Antidepressant treatment during pregnancy. Am J Psychiatry 169:121–124PubMedGoogle Scholar
  90. 90.
    Domar AD, Moragianni VA, Ryley DA, Urato AC (2013) The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond. Hum Reprod 28:160–171PubMedGoogle Scholar
  91. 91.
    Flynn HA, Blow FC, Marcus SM (2006) Rates and predictors of depression treatment among pregnant women in hospital-affiliated obstetrics practices. Gen Hosp Psychiatry 28:289–295PubMedGoogle Scholar
  92. 92.
    Parry BL (2009) Assessing risk and benefit: to treat or not to treat major depression during pregnancy with antidepressant medication. Am J Psychiatry 166:557–566Google Scholar
  93. 93.
    Oberlander TF, Warburton W, Misri S et al (2006) Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 63:898–906PubMedGoogle Scholar
  94. 94.
    Salisbury AL, Wisner KL, Pearlstein T et al (2011) Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment. Depress Anxiety 28:1008–1019PubMedPubMedCentralGoogle Scholar
  95. 95.
    GlaxoSmithKline (2005) Use of paroxetine in first trimester of pregnancy may have a small increased risk of birth defects, compared to other antidepressants. GlaxoSmithKline, MississaugaGoogle Scholar
  96. 96.
    Chambers CD, Hernandez-Diaz S, Van Marter LJ et al (2006) Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the new-born. N Engl J Med 354:579–587PubMedGoogle Scholar
  97. 97.
    Pariante CM, Seneviratne G, Howard GL (2011) Should we stop using tricyclic antidepressants in pregnancy? Psychol Med 41:15–17PubMedGoogle Scholar
  98. 98.
    Einarson A, Pistelli A, DeSantis M et al (2008) Evaluation of the risk of congenital cardiovascular defects associated with use of paroxetine during pregnancy. Am J Psychiatry 165:749–752PubMedGoogle Scholar
  99. 99.
    Marroun HEI, White T, Verhulst F, Tiemeier H (2014) Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review. Eur Child Adolesc Psychiatry [Epub ahead of print] Google Scholar
  100. 100.
    Udechuku A, Nquyen T, Hill R, Szego K (2010) Antidepressants in pregnancy: a systematic review. Aust N Z J Psychiatry 44:978–996PubMedGoogle Scholar
  101. 101.
    Einarson TR, Einarson A (2005) Newer antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies. Pharmacoepidemiol Drug Saf 14:823–827PubMedGoogle Scholar
  102. 102.
    Oberlander TF, Reebye P, Misri S et al (2007) Externalizing and attentional behaviours in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy. Arch Pediatr Adolesc Med 161:22–29PubMedGoogle Scholar
  103. 103.
    Nulman I, Rovet J, Stewart DE et al (2002) Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective controlled study. Am J Psychiatry 159:1889–1895PubMedGoogle Scholar
  104. 104.
    Oberlander TF, Papsdorf M, Brain UM et al (2010) Prenatal effects of selective serotonin re-uptake inhibitor antidepressants, serotonin transporter promoter genotype (SLC6A4) and maternal mood on child behaviour at 3 years of age. Arch Pediatr Adolesc Med 164:444–451PubMedGoogle Scholar
  105. 105.
    National Institute for Health and Clinical Excellence (2007) Clinical practice guideline number 45. Antenatal and postnatal mental health. http://www.nice.org.uk. Accessed 19 Nov 2013
  106. 106.
    Scottish Intercollegiate Guidelines Network (SIGN) (2012) Management of perinatal mood disorders. SIGN publication no. 127, EdinburghGoogle Scholar
  107. 107.
    Dennis CL, Hodnett E (2008) Psychosocial and psychological interventions for treating postpartum depression. Cochrane Database Syst Rev 4:CD006116Google Scholar
  108. 108.
    Rahman A, Fisher J, Bower P et al (2013) Interventions for common perinatal mental disorders in women in low- and middle-income countries: a systematic review and meta-analysis. Bull World Health Organ 91:593–601PubMedPubMedCentralGoogle Scholar
  109. 109.
    Dennis CL, Ross LE, Grigoriadis S (2007) Psychosocial and psychological interventions for treating antenatal depression. Cochrane Database Syst Rev 3:CD006309PubMedGoogle Scholar
  110. 110.
    Spinelli MG, Endicott J (2003) Controlled clinical trial of interpersonal psychotherapy versus parenting education program for depressed pregnant women. Am J Psychiatry 160:555–562PubMedGoogle Scholar
  111. 111.
    Burns A, O’Mahen H, Baxter H et al (2013) A pilot randomised controlled trial of cognitive behavioural therapy for antenatal depression. BMC Psychiatry 13:33PubMedPubMedCentralGoogle Scholar
  112. 112.
    Dennis CL, Dowswell T (2013) Interventions (other than pharmacological, psychosocial or psychological) for treating antenatal depression. Cochrane Database Syst Rev 77:CD006795Google Scholar
  113. 113.
    Field T, Deeds O, Diego M (2013) Benefits of combining massage therapy with group interpersonal psychotherapy in prenatally depressed women. J Body Work Mov Ther 13:297–303Google Scholar
  114. 114.
    Poobalan AS, Aucott LS, Ross L, Smith WC, Helms PJ, Williams JH (2007) Effects of treating postnatal depression on mother–infant interaction and child development: systematic review. Br J Psychiatry 19:378–386Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Cerith S. Waters
    • 1
  • Dale F. Hay
    • 1
  • Jessica R. Simmonds
    • 1
  • Stephanie H. M. van Goozen
    • 1
  1. 1.Cardiff UniversityCardiffUK

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