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European Child & Adolescent Psychiatry

, Volume 22, Issue 6, pp 379–384 | Cite as

Major depression in young girls is related to altered cortisol awakening response

  • Schmidt Ulrike
  • Laessle Reinhold
  • Hellhammer Dirk
Brief Report

Abstract

Background

There is evidence that clinical depression is associated with elevated basal cortisol levels in adult patients.

Objective

The present investigation tries to find out, whether this relationship also holds true in adolescents with major depression.

Methods

For 131 female subjects (63 MDD, 68 controls) the cortisol awakening response (CAR) was measured at 0, 30, 45, and 60 min after awakening. All subjects provided saliva cortisol.

Results

A significantly higher CAR was found in patients. The global mean difference was due to differences 60 and 45 min after awakening.

Limitations

A causal interpretation of the data is restricted, because of its cross-sectional nature. The effect size of the mean differences is rather small.

Conclusion

The observed HPA hyperactivity may be a cause as well as a consequence of depression in childhood.

Keywords

Major depression Children Cortisol awakening response 

Notes

Conflict of interest

None

References

  1. 1.
    Adam EK, Doane LD, Zinbarg RE, Mineka S, Craske MG, Griffith JW (2010) Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology 35(6):921–931PubMedCrossRefGoogle Scholar
  2. 2.
    Antonijevic IA (2006) Depressive disorders—is it time to endorse different pathophysiologies? Psychoneuroendocrinology 31:1–15PubMedCrossRefGoogle Scholar
  3. 3.
    Ashman SB, Dawson G, Panagiotides H, Yamada E, Wilkinson CW (2002) Stress hormone levels of children of depressed mothers. Dev Psychopathol 14(2):333–349PubMedCrossRefGoogle Scholar
  4. 4.
    Chida Y, Steptoe A (2009) Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol 80:265–278PubMedCrossRefGoogle Scholar
  5. 5.
    Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L (2010) The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev 35:97–103PubMedCrossRefGoogle Scholar
  6. 6.
    De Kloet ER (1991) Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 12:95–164Google Scholar
  7. 7.
    Eschenbeck H, Kohlmann CW, Lohaus A, Klein-Heßling J (2006) Die Diagnostik von Stressbewältigung mit dem “Fragebogen zur Erhebung von Stress und Stressbewältigung im Kindes- und Jugendalter“ (SSKJ 3–8). Faktorielle und psychometrische Analysen Diagnostica 52(3):131–142CrossRefGoogle Scholar
  8. 8.
    Federenko I, Wüst S, Hellhammer DH, Dechoux R, Kumsta R, Kirschbaum C (2004) Free cortisol awakening responses are influenced by awakening time. Psychoneuroendocrinology 29:174–184PubMedCrossRefGoogle Scholar
  9. 9.
    Fries E, Dettenborn L, Kirschbaum C (2009) The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol 35:752–757Google Scholar
  10. 10.
    Goodyer IM, Herbert J, Tamplin A (2003) Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry. Psychol Med 33(4):601–610PubMedCrossRefGoogle Scholar
  11. 11.
    Goodyer IM, Herbert J, Tamplin A, Altham PME (2000) Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. Br J Psychiatry 177:499–504PubMedCrossRefGoogle Scholar
  12. 12.
    Guerry JD, Hastings PD (2011) In search of HPA axis dysregulation in child and adolescent depression. Clin Child Fam Psychol Rev 14(2):135–160PubMedCrossRefGoogle Scholar
  13. 13.
    Hankin BL, Badanes LS, Abela JRZ, Watamura SE (2010) Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biol Psychiatry 68:484–490PubMedCrossRefGoogle Scholar
  14. 14.
    Heaney JL, Phillips AC, Carroll D (2010) Aging, depression, anxiety, social support and the diurnal rhythm and awakening response of salivary cortisol. Int J Psychophysiol 78(3):201–208PubMedCrossRefGoogle Scholar
  15. 15.
    In-Albon T, Suppiger A, Schlup B, Wendler S, Margraf J, Schneider S (2008) Validität des Diagnostischen Interviews bei psychischen Störungen (DIPS für DSM-IV-TR). Zeitschrift für Klinische Psychologie und Psychotherapie 37(1):33–42CrossRefGoogle Scholar
  16. 16.
    Kudielka BM, Gierens A, Hellhammer DH, Wüst S, Schlotz W (2012) Salivary cortisol in ambulatory assessment—some dos, some don’ts, and some open questions. Psychosom Med 74(4):418–431PubMedCrossRefGoogle Scholar
  17. 17.
    Kudielka BM, Kirschbaum C (2003) Awakening cortisol responses are influeced by health status and awakening time but not by menstrual cycle phase. Psychoneuroendocrinology 28:35–47PubMedCrossRefGoogle Scholar
  18. 18.
    Kudielka BM, Wüst S (2008) The cortisol awakening response (CAR): A tool for ambulant assessment of hypothalamus-pituitary-adrenal (HPA) axis activity. In: Columbus F (ed). Nova Science Publishers Inc, New YorkGoogle Scholar
  19. 19.
    Kunz-Ebrecht SR, Kirschbaum C, Marmot M, Steptoe A (2004) Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall neuroendocrine activation over the working day. Psychoneuroendocrinology 29:516–528PubMedCrossRefGoogle Scholar
  20. 20.
    Lohaus A, Eschenbeck H, Kohlmann C-W, Klein-Heßling J (2006) SSKJ 3–8: Fragebogen zur Erhebung von Stress und Stressbewältigung im Kindes-und Jugendalter. Hogrefe, GöttingenGoogle Scholar
  21. 21.
    Lopez-Duran N, Kovacs M, George C (2009) Hypothalamic pituitary adrenal axis dysregulation in depressed children and adolescents: a meta-analysis. Psychoneuroendocrinology 34(9):1272–1283Google Scholar
  22. 22.
    Mannie ZN, Harmer CJ, Cowen PJ (2007) Increased waking salivary cortisol levels in young people at familial risk of depression. Am J Psychiatry 164:617–621PubMedCrossRefGoogle Scholar
  23. 23.
    Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31(9):464–468PubMedCrossRefGoogle Scholar
  24. 24.
    Pfeffer CR, Altemus M, Heo M, Jiang H (2007) Salivary cortisol and psychopathology in children bereaved by the September 11, 2001 terror attacks. Biol Psychiatry 61(8):957–965PubMedCrossRefGoogle Scholar
  25. 25.
    Pruessner JC, Wolf OT, Hellhammer DH, Buske-Kirschbaum A, von Auer K, Jobst S, Kaspers F, Kirschbaum C (1997) Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci 61(26):2539–2549PubMedCrossRefGoogle Scholar
  26. 26.
    Rao U, Chen L-A (2009) Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders. Dialogues Clin Neurosci 11(1):45–62PubMedGoogle Scholar
  27. 27.
    Rao U, Hammen C, Ortiz L, Chen L-A, Poland R (2008) Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry 64:521–526Google Scholar
  28. 28.
    Schulz P et al (1998) Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload. Stress Med 14:91–97CrossRefGoogle Scholar
  29. 29.
    Schlotz W, Hellhammer J, Schulz P, Stone AA (2004) Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response. Psychosom Med 66(2):207–214Google Scholar
  30. 30.
    Schweisthal, O. W., 2007. Der Cortisol Awakening Response in der Diagnostik stressbezogener Erkrankungen. Dissertation, Universität TrierGoogle Scholar
  31. 31.
    Suppiger A, In-Albon T, Herren C, Bader K, Schneider S, Margraf J (2008) Reliabilität des Diagnostischen Interviews bei psychischen Störungen (DIPS für DSM-IV-TR). Verhaltenstherapie 18(4):237–244CrossRefGoogle Scholar
  32. 32.
    Tanner JM (1962) Growth at adolescence. Blackwell Scientific Publications, OxfordGoogle Scholar
  33. 33.
    Unnewehr S, Schneider S, Margraf J (2002) Diagnostisches Interview bei psychischen Störungen im Kindes- und Jugendalter. Hogrefe, GöttingenGoogle Scholar
  34. 34.
    Van den Bergh BR, Van Calster B (2009) Diurnal cortisol profiles and evening cortisol in post-pubertal adolescents scoring high on the children’s depression inventory. Psychoneuroendocrinology 34(5):791–794PubMedCrossRefGoogle Scholar
  35. 35.
    Williams E, Magid K, Steptoe A (2005) The impact of time of waking and concurrent subjective stress on the cortisol response to awakening. Psychoneuroendocrinology 30:139–148PubMedCrossRefGoogle Scholar
  36. 36.
    Wüst S, Federenko I, Hellhammer DH, Kirschbaum C (2000) Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology 25:707–720PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Schmidt Ulrike
    • 1
  • Laessle Reinhold
    • 1
  • Hellhammer Dirk
    • 1
  1. 1.Department of Clinical and Physiological PsychologyUniversity of TrierTrierGermany

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